dc.contributor.author | Whisenant, JG | |
dc.contributor.author | Baena, J | |
dc.contributor.author | Cortellini, A | |
dc.contributor.author | Huang, L-C | |
dc.contributor.author | Lo Russo, G | |
dc.contributor.author | Porcu, L | |
dc.contributor.author | Wong, SK | |
dc.contributor.author | Bestvina, CM | |
dc.contributor.author | Hellmann, MD | |
dc.contributor.author | Roca, E | |
dc.contributor.author | Rizvi, H | |
dc.contributor.author | Monnet, I | |
dc.contributor.author | Boudjemaa, A | |
dc.contributor.author | Rogado, J | |
dc.contributor.author | Pasello, G | |
dc.contributor.author | Leighl, NB | |
dc.contributor.author | Arrieta, O | |
dc.contributor.author | Aujayeb, A | |
dc.contributor.author | Batra, U | |
dc.contributor.author | Azzam, AY | |
dc.contributor.author | Unk, M | |
dc.contributor.author | Azab, MA | |
dc.contributor.author | Zhumagaliyeva, AN | |
dc.contributor.author | Gomez-Martin, C | |
dc.contributor.author | Blaquier, JB | |
dc.contributor.author | Geraedts, E | |
dc.contributor.author | Mountzios, G | |
dc.contributor.author | Serrano-Montero, G | |
dc.contributor.author | Reinmuth, N | |
dc.contributor.author | Coate, L | |
dc.contributor.author | Marmarelis, M | |
dc.contributor.author | Presley, CJ | |
dc.contributor.author | Hirsch, FR | |
dc.contributor.author | Garrido, P | |
dc.contributor.author | Khan, H | |
dc.contributor.author | Baggi, A | |
dc.contributor.author | Mascaux, C | |
dc.contributor.author | Halmos, B | |
dc.contributor.author | Ceresoli, GL | |
dc.contributor.author | Fidler, MJ | |
dc.contributor.author | Scotti, V | |
dc.contributor.author | Métivier, A-C | |
dc.contributor.author | Falchero, L | |
dc.contributor.author | Felip, E | |
dc.contributor.author | Genova, C | |
dc.contributor.author | Mazieres, J | |
dc.contributor.author | Tapan, U | |
dc.contributor.author | Brahmer, J | |
dc.contributor.author | Bria, E | |
dc.contributor.author | Puri, S | |
dc.contributor.author | Popat, S | |
dc.contributor.author | Reckamp, KL | |
dc.contributor.author | Morgillo, F | |
dc.contributor.author | Nadal, E | |
dc.contributor.author | Mazzoni, F | |
dc.contributor.author | Agustoni, F | |
dc.contributor.author | Bar, J | |
dc.contributor.author | Grosso, F | |
dc.contributor.author | Avrillon, V | |
dc.contributor.author | Patel, JD | |
dc.contributor.author | Gomes, F | |
dc.contributor.author | Ibrahim, E | |
dc.contributor.author | Trama, A | |
dc.contributor.author | Bettini, AC | |
dc.contributor.author | Barlesi, F | |
dc.contributor.author | Dingemans, A-M | |
dc.contributor.author | Wakelee, H | |
dc.contributor.author | Peters, S | |
dc.contributor.author | Horn, L | |
dc.contributor.author | Garassino, MC | |
dc.contributor.author | Torri, V | |
dc.contributor.author | TERAVOLT study group | |
dc.date.accessioned | 2022-04-13T08:46:27Z | |
dc.date.available | 2022-04-13T08:46:27Z | |
dc.date.issued | 2022-01-24 | |
dc.identifier.citation | Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2022 | en |
dc.identifier.issn | 1556-0864 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/5076 | |
dc.identifier.eissn | 1556-1380 | en_US |
dc.identifier.eissn | 1556-1380 | |
dc.identifier.doi | 10.1016/j.jtho.2021.12.015 | en_US |
dc.identifier.doi | 10.1016/j.jtho.2021.12.015 | |
dc.description.abstract | <h4>Background</h4>Patients with thoracic malignancies are at increased risk for mortality from Coronavirus disease 2019 (COVID-19) and large number of intertwined prognostic variables have been identified so far.<h4>Methods</h4>Capitalizing data from the TERAVOLT registry, a global study created with the aim of describing the impact of COVID-19 in patients with thoracic malignancies, we used a clustering approach, a fast-backward step-down selection procedure and a tree-based model to screen and optimize a broad panel of demographics, clinical COVID-19 and cancer characteristics.<h4>Results</h4>As of April 15, 2021, 1491 consecutive evaluable patients from 18 countries were included in the analysis. With a mean observation period of 42 days, 361 events were reported with an all-cause case fatality rate of 24.2%. The clustering procedure screened approximately 73 covariates in 13 clusters. A further multivariable logistic regression for the association between clusters and death was performed, resulting in five clusters significantly associated with the outcome. The fast-backward step-down selection then identified seven major determinants of death ECOG-PS (OR 2.47 1.87-3.26), neutrophil count (OR 2.46 1.76-3.44), serum procalcitonin (OR 2.37 1.64-3.43), development of pneumonia (OR 1.95 1.48-2.58), c-reactive protein (CRP) (OR 1.90 1.43-2.51), tumor stage at COVID-19 diagnosis (OR 1.97 1.46-2.66) and age (OR 1.71 1.29-2.26). The ROC analysis for death of the selected model confirmed its diagnostic ability (AUC 0.78; 95%CI: 0.75 - 0.81). The nomogram was able to classify the COVID-19 mortality in an interval ranging from 8% to 90% and the tree-based model recognized ECOG-PS, neutrophil count and CRP as the major determinants of prognosis.<h4>Conclusion</h4>From 73 variables analyzed, seven major determinants of death have been identified. Poor ECOG-PS demonstrated the strongest association with poor outcome from COVID-19. With our analysis we provide clinicians with a definitive prognostication system to help determine the risk of mortality for patients with thoracic malignancies and COVID-19. | en_US |
dc.format | Print-Electronic | en_US |
dc.language | eng | en_US |
dc.language.iso | eng | en |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | en |
dc.subject | TERAVOLT study group | en_US |
dc.title | A definitive prognostication system for patients with thoracic malignancies diagnosed with COVID-19: an update from the TERAVOLT registry. | en |
dc.type | Journal Article | |
dcterms.dateAccepted | 2021-12-31 | |
rioxxterms.version | AM | en |
rioxxterms.versionofrecord | 10.1016/j.jtho.2021.12.015 | en |
rioxxterms.licenseref.startdate | 2022-01-24 | |
dc.relation.isPartOf | Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer | en_US |
pubs.notes | Not known | en_US |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Thoracic Oncology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Thoracic Oncology/Thoracic Oncology (hon.) | |
pubs.publication-status | Published | en_US |
pubs.embargo.terms | Not known | en_US |
icr.researchteam | Thoracic Oncology | |
dc.contributor.icrauthor | Popat, Sanjay | |