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dc.contributor.authorSmyth, EC
dc.contributor.authorTarazona, N
dc.contributor.authorPeckitt, C
dc.contributor.authorArmstrong, E
dc.contributor.authorMansukhani, S
dc.contributor.authorCunningham, D
dc.contributor.authorChau, I
dc.date.accessioned2017-03-24T14:48:26Z
dc.date.issued2016-06
dc.identifier.citationClinical colorectal cancer, 2016, 15 (2), pp. e53 - e59
dc.identifier.issn1533-0028
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/515
dc.identifier.eissn1938-0674
dc.identifier.doi10.1016/j.clcc.2015.11.003
dc.description.abstractBackground Strict eligibility criteria are necessary to maintain patient safety and scientific validity in clinical trials. However, this may lead to impaired generalizability of results. As survival in gastrointestinal (GI) cancer relates mainly to the GI malignancy, we hypothesized that previous cancers do not impact on survival and are not a rational exclusion criterion.Materials and methods Patients treated with chemotherapy for a GI cancer in 2006 were identified from the electronic patient record at the Royal Marsden Hospital, London. Chart review was performed and patient age, gender, GI cancer stage, prior cancer stage, clinical trial availability/eligibility, and dates of cancer recurrence, death, and last follow-up were collated.Results A total of 697 patients were identified. Fifty-four patients (8%) had a prior cancer; commonly breast (26%), prostate (17%), or colon (9%); most were stage I (42%) or II (37%). Two hundred ninety-seven (65%) patients had GI cancer recurrence, 7 (12%) patients had relapse of a prior cancer. Five hundred four (72%) patients have died, 170 (24%) are alive with no cancer, and 23 (3%) patients are alive with cancer. A total of 476 (94%) died of GI cancer, 2 (0.3%) of their prior cancer. Of all patients, 489 (70%) had an available trial, but 30% of patients with a prior cancer were ineligible for this reason. Overall and GI-cancer-specific survival were comparable for patients with/without a prior cancer.Conclusions Survival for patients with a GI cancer requiring chemotherapy relates to the GI cancer and rarely a prior cancer. These patients should not be excluded from clinical trial participation.
dc.formatPrint-Electronic
dc.format.extente53 - e59
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://www.rioxx.net/licenses/all-rights-reserved
dc.subjectHumans
dc.subjectGastrointestinal Neoplasms
dc.subjectNeoplasms, Second Primary
dc.subjectNeoplasm Recurrence, Local
dc.subjectTreatment Outcome
dc.subjectProportional Hazards Models
dc.subjectRetrospective Studies
dc.subjectPatient Selection
dc.subjectAged
dc.subjectMiddle Aged
dc.subjectFemale
dc.subjectMale
dc.subjectKaplan-Meier Estimate
dc.titleExclusion of Gastrointestinal Cancer Patients With Prior Cancer From Clinical Trials: Is This Justified?
dc.typeJournal Article
dcterms.dateAccepted2015-11-23
rioxxterms.versionofrecord10.1016/j.clcc.2015.11.003
rioxxterms.licenseref.urihttps://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2016-06
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfClinical colorectal cancer
pubs.issue2
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Medicine (RMH Smith Cunningham)
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Medicine (RMH Smith Cunningham)/Medicine (RMH Smith Cunningham) (hon.)
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Medicine (RMH Smith Cunningham)
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Medicine (RMH Smith Cunningham)/Medicine (RMH Smith Cunningham) (hon.)
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.publication-statusPublished
pubs.volume15
pubs.embargo.termsNot known
icr.researchteamMedicine (RMH Smith Cunningham)en_US
dc.contributor.icrauthorSmyth, Lizzyen
dc.contributor.icrauthorCunningham, Daviden
dc.contributor.icrauthorChau, Ianen


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