dc.contributor.author | Sjoberg Bexelius, T | |
dc.contributor.author | Chisholm, JC | |
dc.contributor.author | Okoye, B | |
dc.contributor.author | Cecil, T | |
dc.contributor.author | Angelini, P | |
dc.contributor.author | Dayal, S | |
dc.coverage.spatial | England | |
dc.date.accessioned | 2022-07-14T14:43:23Z | |
dc.date.available | 2022-07-14T14:43:23Z | |
dc.date.issued | 2021-01-28 | |
dc.identifier | ARTN e234876 | |
dc.identifier | 14/1/e234876 | |
dc.identifier.citation | BMJ Case Reports, 2021, 14 (1), pp. e234876 - | |
dc.identifier.issn | 1757-790X | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/5232 | |
dc.identifier.eissn | 1757-790X | |
dc.identifier.eissn | 1757-790X | |
dc.identifier.doi | 10.1136/bcr-2020-234876 | |
dc.description.abstract | We present the first young paediatric patient with desmoplastic small round cell tumour (DSRCT) treated in UK with hyperthermic intraperitoneal chemotherapy (HIPEC). A 7-year-old girl was diagnosed with abdominal DSRCT with peritoneal and liver metastases. After six cycles of chemotherapy she obtained a partial response, including almost complete resolution of the two liver metastases. It was decided to pursue cytoreductive surgery (CRS) combined with HIPEC, a procedure commonly performed in adults, but seldom in a child. The surgery was macroscopically complete and the HIPEC uncomplicated. She continued treatment without delays, including whole abdomino-pelvic radiotherapy and maintenance chemotherapy (cyclophosphamide/vinorelbine for 12 months). She is currently in complete remission 4 months after end of treatment and 26 months after diagnosis. HIPEC was made possible by successful collaboration between multiple teams. CRS-HIPEC proved to be safe and feasible and could be offered to other children with diagnoses of peritoneal malignancies across the UK. | |
dc.format | Electronic | |
dc.format.extent | e234876 - | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | BMJ PUBLISHING GROUP | |
dc.relation.ispartof | BMJ Case Reports | |
dc.rights.uri | http://www.rioxx.net/licenses/all-rights-reserved | |
dc.subject | malignant disease and immunosuppression | |
dc.subject | paediatric oncology | |
dc.subject | paediatrics (drugs and medicines) | |
dc.subject | Antineoplastic Agents | |
dc.subject | Antineoplastic Combined Chemotherapy Protocols | |
dc.subject | Child | |
dc.subject | Cisplatin | |
dc.subject | Cyclophosphamide | |
dc.subject | Cytoreduction Surgical Procedures | |
dc.subject | Desmoplastic Small Round Cell Tumor | |
dc.subject | Doxorubicin | |
dc.subject | Etoposide | |
dc.subject | Female | |
dc.subject | Humans | |
dc.subject | Hyperthermic Intraperitoneal Chemotherapy | |
dc.subject | Ifosfamide | |
dc.subject | Liver Neoplasms | |
dc.subject | Maintenance Chemotherapy | |
dc.subject | Neoadjuvant Therapy | |
dc.subject | Pelvic Neoplasms | |
dc.subject | Peritoneal Neoplasms | |
dc.subject | Radiotherapy | |
dc.subject | Remission Induction | |
dc.subject | United Kingdom | |
dc.subject | Vincristine | |
dc.subject | Vinorelbine | |
dc.title | Hyperthermic intraperitoneal chemotherapy (HIPEC) as another treatment modality for desmoplastic round cell tumour patients: first paediatric experience from UK. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2020-12-05 | |
dc.date.updated | 2022-07-14T14:38:42Z | |
rioxxterms.version | VoR | |
rioxxterms.versionofrecord | 10.1136/bcr-2020-234876 | |
rioxxterms.licenseref.startdate | 2021-01-28 | |
rioxxterms.type | Journal Article/Review | |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/33509853 | |
pubs.issue | 1 | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Sarcoma Clinical Trials in Children and Young People | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Sarcoma Clinical Trials in children and young people | |
pubs.organisational-group | /ICR/Primary Group/Royal Marsden Clinical Units | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Sarcoma Clinical Trials in Children and Young People/Sarcoma Clinical Trials in Children and Young People (hon.) | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Sarcoma Clinical Trials in children and young people/Sarcoma Clinical Trials in Children and Young People (hon.) | |
pubs.publication-status | Published online | |
pubs.volume | 14 | |
dc.contributor.icrauthor | Angelini, Paola | |
icr.provenance | Deposited by Dr Julia Chisholm on 2022-07-14. Deposit type is initial. No. of files: 1. Files: Hyperthermic_intraperitoneal_c.pdf | |