dc.contributor.author | Aeppli, S | |
dc.contributor.author | Eboulet, EI | |
dc.contributor.author | Eisen, T | |
dc.contributor.author | Escudier, B | |
dc.contributor.author | Fischer, S | |
dc.contributor.author | Larkin, J | |
dc.contributor.author | Gruenwald, V | |
dc.contributor.author | McDermott, D | |
dc.contributor.author | Oldenburg, J | |
dc.contributor.author | Omlin, A | |
dc.contributor.author | Porta, C | |
dc.contributor.author | Rini, B | |
dc.contributor.author | Schmidinger, M | |
dc.contributor.author | Sternberg, C | |
dc.contributor.author | Rothermundt, C | |
dc.coverage.spatial | England | |
dc.date.accessioned | 2022-08-22T15:17:55Z | |
dc.date.available | 2022-08-22T15:17:55Z | |
dc.date.issued | 2020-05-01 | |
dc.identifier | ARTN e000852 | |
dc.identifier | S2059-7029(20)32678-8 | |
dc.identifier.citation | ESMO Open, 2020, 5 (Suppl 3), pp. e000852 - | en_US |
dc.identifier.issn | 2059-7029 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/5297 | |
dc.identifier.eissn | 2059-7029 | |
dc.identifier.eissn | 2059-7029 | |
dc.identifier.doi | 10.1136/esmoopen-2020-000852 | |
dc.description.abstract | BACKGROUND: The coronavirus pandemic has provoked discussions among healthcare providers how to manage cancer patients when faced with the threat of severe acute respiratory syndrome related coronavirus 2 (SARS-CoV-2) infection. Immune checkpoint inhibitor (ICI) containing regimens are standard of care in the majority of metastatic clear cell renal cell carcinoma (mccRCC) patients. It remains unclear whether therapies should be modified in response to the COVID-19 pandemic. METHODS: We performed an online survey among physicians involved in the treatment of mccRCC, and 41 experts responded. Questions focused on criteria relevant for treatment decision outside the pandemic and the modifications of systemic therapy during COVID-19. FINDINGS: For the majority of experts (73%), the combination of International metastatic renal cell carcinoma Database Consortium (IMDC) risk category and patient fitness are two important factors for decision-making. The main treatment choice in fit, favourable risk patients outside the pandemic is pembrolizumab/axitinib for 53%, avelumab/axitinib, sunitinib or pazopanib for 13% of experts each. During the pandemic, ICI-containing regimens are chosen less often in favour of a tyrosine kinase inhibitors (TKI) monotherapy, mainly sunitinib or pazopanib (35%).In fit, intermediate/poor-risk patients outside the pandemic, over 80% of experts choose ipilimumab/nivolumab, in contrast to only 41% of physicians during COVID-19, instead more TKI monotherapies are given. In patients responding to established therapies with ICI/ICI or ICI/TKI combinations, most participants modify treatment regimen by extending cycle length, holding one ICI or even both. CONCLUSION: mccRCC treatment modifications in light of the coronavirus pandemic are variable, with a shift from ICI/ICI to ICI/TKI or TKI monotherapy. | |
dc.format | Print | |
dc.format.extent | e000852 - | |
dc.language | eng | |
dc.language.iso | eng | en_US |
dc.publisher | ELSEVIER | en_US |
dc.relation.ispartof | ESMO Open | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0 | en_US |
dc.subject | COVID-19 | |
dc.subject | decision criteria | |
dc.subject | pandemic | |
dc.subject | renal cell carcinoma | |
dc.subject | treatment pattern | |
dc.subject | Antineoplastic Agents | |
dc.subject | Betacoronavirus | |
dc.subject | COVID-19 | |
dc.subject | Carcinoma, Renal Cell | |
dc.subject | Clinical Decision-Making | |
dc.subject | Coronavirus Infections | |
dc.subject | Humans | |
dc.subject | Immunologic Factors | |
dc.subject | Kidney Neoplasms | |
dc.subject | Medical Oncology | |
dc.subject | Pandemics | |
dc.subject | Pneumonia, Viral | |
dc.subject | Practice Patterns, Physicians' | |
dc.subject | Protein Kinase Inhibitors | |
dc.subject | SARS-CoV-2 | |
dc.subject | Urology | |
dc.title | Impact of COVID-19 pandemic on treatment patterns in metastatic clear cell renal cell carcinoma. | en_US |
dc.type | Journal Article | |
dcterms.dateAccepted | 2020-06-24 | |
dc.date.updated | 2022-08-22T15:17:22Z | |
rioxxterms.version | VoR | en_US |
rioxxterms.versionofrecord | 10.1136/esmoopen-2020-000852 | en_US |
rioxxterms.licenseref.startdate | 2020-05-01 | |
rioxxterms.type | Journal Article/Review | en_US |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/32669298 | |
pubs.issue | Suppl 3 | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Melanoma and Kidney Cancer | |
pubs.organisational-group | /ICR/Primary Group/Royal Marsden Clinical Units | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Melanoma and Kidney Cancer/Melanoma and Kidney Cancer (hon.) | |
pubs.publication-status | Published | |
pubs.volume | 5 | |
dc.contributor.icrauthor | Larkin, James | |
icr.provenance | Deposited by Mr Arek Surman on 2022-08-22. Deposit type is initial. No. of files: 1. Files: Impact of COVID-19 pandemic on treatment patterns in metastatic clear cell renal cell carcinoma. .pdf | |