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dc.contributor.authorHayes, AJ
dc.contributor.authorMoskovic, E
dc.contributor.authorO'Meara, K
dc.contributor.authorSmith, HG
dc.contributor.authorPope, RJE
dc.contributor.authorLarkin, J
dc.contributor.authorThomas, JM
dc.coverage.spatialEngland
dc.date.accessioned2022-08-26T10:53:12Z
dc.date.available2022-08-26T10:53:12Z
dc.date.issued2019-05-01
dc.identifier.citationBritish Journal of Surgery, 2019, 106 (6), pp. 729 - 734en_US
dc.identifier.issn0007-1323
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/5334
dc.identifier.eissn1365-2168
dc.identifier.eissn1365-2168
dc.identifier.doi10.1002/bjs.11112
dc.description.abstractBACKGROUND: For patients with intermediate-thickness melanoma, surveillance of regional lymph node basins by clinical examination alone has been reported to result in a larger number of lymph nodes involved by melanoma than if patients had initial sentinel node biopsy and completion dissection. This may result in worse regional control. A prospective study of both regular clinical examination and ultrasound surveillance was conducted to assess the effectiveness of these modalities. METHODS: Between 2010 and 2014, patients with melanoma of thickness 1·2-3·5 mm who had under-gone wide local excision but not sentinel node biopsy were recruited to a prospective observational study of regular clinical and ultrasound nodal surveillance. The primary endpoint was nodal burden within a dissected regional lymph node basin. Secondary endpoints included locoregional or distant relapse, progression-free and overall survival. RESULTS: Ninety patients were included in the study. After a median follow-up of 52 months, ten patients had developed nodal relapse as first recurrence, four had locoregional disease outside of an anatomical nodal basin as the first site of relapse and six had relapse with distant disease. None of the patients who developed relapse within a nodal basin presented with unresectable nodal disease. The median number of involved lymph nodes in patients undergoing lymphadenectomy for nodal relapse was 1 (range 1-2; mean 1·2). CONCLUSION: This study suggests that ultrasound surveillance of regional lymph node basins is safe for patients with melanoma who undergo a policy of nodal surveillance.
dc.formatPrint-Electronic
dc.format.extent729 - 734
dc.languageeng
dc.language.isoengen_US
dc.publisherWILEYen_US
dc.relation.ispartofBritish Journal of Surgery
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectFemale
dc.subjectFollow-Up Studies
dc.subjectHumans
dc.subjectLymph Node Excision
dc.subjectLymph Nodes
dc.subjectLymphatic Metastasis
dc.subjectMale
dc.subjectMelanoma
dc.subjectMiddle Aged
dc.subjectNeoplasm Recurrence, Local
dc.subjectPostoperative Care
dc.subjectProspective Studies
dc.subjectSkin Neoplasms
dc.subjectSurvival Analysis
dc.subjectTreatment Outcome
dc.titleProspective cohort study of ultrasound surveillance of regional lymph nodes in patients with intermediate-risk cutaneous melanoma.en_US
dc.typeJournal Article
dcterms.dateAccepted2018-12-11
dc.date.updated2022-08-26T10:52:36Z
rioxxterms.versionVoRen_US
rioxxterms.versionofrecord10.1002/bjs.11112en_US
rioxxterms.licenseref.startdate2019-05-01
rioxxterms.typeJournal Article/Reviewen_US
pubs.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/30816996
pubs.issue6
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Melanoma and Kidney Cancer
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Melanoma and Kidney Cancer/Melanoma and Kidney Cancer (hon.)
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Sarcoma and Melanoma Surgery
pubs.organisational-group/ICR/Students
pubs.organisational-group/ICR/Students/PhD and MPhil
pubs.organisational-group/ICR/Students/PhD and MPhil/14/15 Starting Cohort
pubs.publication-statusPublished
pubs.volume106
icr.researchteamSarcoma&Melanoma Surgeryen_US
dc.contributor.icrauthorHayes, Andrew
dc.contributor.icrauthorSmith, Henry
dc.contributor.icrauthorLarkin, James
icr.provenanceDeposited by Mr Arek Surman (impersonating Prof James Larkin) on 2022-08-26. Deposit type is initial. No. of files: 1. Files: Prospective cohort study of ultrasound surveillance of regional lymph nodes in patients with intermediate-risk cutaneous mel.pdf


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