dc.contributor.author | Hayes, AJ | |
dc.contributor.author | Moskovic, E | |
dc.contributor.author | O'Meara, K | |
dc.contributor.author | Smith, HG | |
dc.contributor.author | Pope, RJE | |
dc.contributor.author | Larkin, J | |
dc.contributor.author | Thomas, JM | |
dc.coverage.spatial | England | |
dc.date.accessioned | 2022-08-26T10:53:12Z | |
dc.date.available | 2022-08-26T10:53:12Z | |
dc.date.issued | 2019-05-01 | |
dc.identifier.citation | British Journal of Surgery, 2019, 106 (6), pp. 729 - 734 | en_US |
dc.identifier.issn | 0007-1323 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/5334 | |
dc.identifier.eissn | 1365-2168 | |
dc.identifier.eissn | 1365-2168 | |
dc.identifier.doi | 10.1002/bjs.11112 | |
dc.description.abstract | BACKGROUND: For patients with intermediate-thickness melanoma, surveillance of regional lymph node basins by clinical examination alone has been reported to result in a larger number of lymph nodes involved by melanoma than if patients had initial sentinel node biopsy and completion dissection. This may result in worse regional control. A prospective study of both regular clinical examination and ultrasound surveillance was conducted to assess the effectiveness of these modalities. METHODS: Between 2010 and 2014, patients with melanoma of thickness 1·2-3·5 mm who had under-gone wide local excision but not sentinel node biopsy were recruited to a prospective observational study of regular clinical and ultrasound nodal surveillance. The primary endpoint was nodal burden within a dissected regional lymph node basin. Secondary endpoints included locoregional or distant relapse, progression-free and overall survival. RESULTS: Ninety patients were included in the study. After a median follow-up of 52 months, ten patients had developed nodal relapse as first recurrence, four had locoregional disease outside of an anatomical nodal basin as the first site of relapse and six had relapse with distant disease. None of the patients who developed relapse within a nodal basin presented with unresectable nodal disease. The median number of involved lymph nodes in patients undergoing lymphadenectomy for nodal relapse was 1 (range 1-2; mean 1·2). CONCLUSION: This study suggests that ultrasound surveillance of regional lymph node basins is safe for patients with melanoma who undergo a policy of nodal surveillance. | |
dc.format | Print-Electronic | |
dc.format.extent | 729 - 734 | |
dc.language | eng | |
dc.language.iso | eng | en_US |
dc.publisher | WILEY | en_US |
dc.relation.ispartof | British Journal of Surgery | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en_US |
dc.subject | Adult | |
dc.subject | Aged | |
dc.subject | Aged, 80 and over | |
dc.subject | Female | |
dc.subject | Follow-Up Studies | |
dc.subject | Humans | |
dc.subject | Lymph Node Excision | |
dc.subject | Lymph Nodes | |
dc.subject | Lymphatic Metastasis | |
dc.subject | Male | |
dc.subject | Melanoma | |
dc.subject | Middle Aged | |
dc.subject | Neoplasm Recurrence, Local | |
dc.subject | Postoperative Care | |
dc.subject | Prospective Studies | |
dc.subject | Skin Neoplasms | |
dc.subject | Survival Analysis | |
dc.subject | Treatment Outcome | |
dc.title | Prospective cohort study of ultrasound surveillance of regional lymph nodes in patients with intermediate-risk cutaneous melanoma. | en_US |
dc.type | Journal Article | |
dcterms.dateAccepted | 2018-12-11 | |
dc.date.updated | 2022-08-26T10:52:36Z | |
rioxxterms.version | VoR | en_US |
rioxxterms.versionofrecord | 10.1002/bjs.11112 | en_US |
rioxxterms.licenseref.startdate | 2019-05-01 | |
rioxxterms.type | Journal Article/Review | en_US |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/30816996 | |
pubs.issue | 6 | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Melanoma and Kidney Cancer | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/Royal Marsden Clinical Units | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Melanoma and Kidney Cancer/Melanoma and Kidney Cancer (hon.) | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Sarcoma and Melanoma Surgery | |
pubs.organisational-group | /ICR/Students | |
pubs.organisational-group | /ICR/Students/PhD and MPhil | |
pubs.organisational-group | /ICR/Students/PhD and MPhil/14/15 Starting Cohort | |
pubs.publication-status | Published | |
pubs.volume | 106 | |
icr.researchteam | Sarcoma&Melanoma Surgery | en_US |
dc.contributor.icrauthor | Hayes, Andrew | |
dc.contributor.icrauthor | Smith, Henry | |
dc.contributor.icrauthor | Larkin, James | |
icr.provenance | Deposited by Mr Arek Surman (impersonating Prof James Larkin) on 2022-08-26. Deposit type is initial. No. of files: 1. Files: Prospective cohort study of ultrasound surveillance of regional lymph nodes in patients with intermediate-risk cutaneous mel.pdf | |