dc.contributor.author | Ovarian Cancer Association Consortium, Breast Cancer Association Consortium, and Consortium of Modifiers of BRCA1 and BRCA2, | |
dc.contributor.author | Hollestelle, A | |
dc.contributor.author | van der Baan, FH | |
dc.contributor.author | Berchuck, A | |
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dc.contributor.author | Andrulis, IL | |
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dc.contributor.author | Arun, BK | |
dc.contributor.author | Arver, B | |
dc.contributor.author | Ashworth, A | |
dc.contributor.author | Australian Ovarian Cancer Study Group, | |
dc.contributor.author | Baglietto, L | |
dc.contributor.author | Balleine, R | |
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dc.contributor.author | Breast Cancer Family Register, | |
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dc.contributor.author | KConFab Investigators, | |
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dc.contributor.author | Zheng, W | |
dc.contributor.author | Ziogas, A | |
dc.contributor.author | Chenevix-Trench, G | |
dc.contributor.author | Pharoah, PDP | |
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dc.contributor.author | Goode, EL | |
dc.date.accessioned | 2017-04-03T09:39:30Z | |
dc.date.issued | 2016-05-01 | |
dc.identifier.citation | Gynecologic oncology, 2016, 141 (2), pp. 386 - 401 | |
dc.identifier.issn | 0090-8258 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/540 | |
dc.identifier.eissn | 1095-6859 | |
dc.identifier.doi | 10.1016/j.ygyno.2015.04.034 | |
dc.description.abstract | OBJECTIVE: Clinical genetic testing is commercially available for rs61764370, an inherited variant residing in a KRAS 3' UTR microRNA binding site, based on suggested associations with increased ovarian and breast cancer risk as well as with survival time. However, prior studies, emphasizing particular subgroups, were relatively small. Therefore, we comprehensively evaluated ovarian and breast cancer risks as well as clinical outcome associated with rs61764370. METHODS: Centralized genotyping and analysis were performed for 140,012 women enrolled in the Ovarian Cancer Association Consortium (15,357 ovarian cancer patients; 30,816 controls), the Breast Cancer Association Consortium (33,530 breast cancer patients; 37,640 controls), and the Consortium of Modifiers of BRCA1 and BRCA2 (14,765 BRCA1 and 7904 BRCA2 mutation carriers). RESULTS: We found no association with risk of ovarian cancer (OR=0.99, 95% CI 0.94-1.04, p=0.74) or breast cancer (OR=0.98, 95% CI 0.94-1.01, p=0.19) and results were consistent among mutation carriers (BRCA1, ovarian cancer HR=1.09, 95% CI 0.97-1.23, p=0.14, breast cancer HR=1.04, 95% CI 0.97-1.12, p=0.27; BRCA2, ovarian cancer HR=0.89, 95% CI 0.71-1.13, p=0.34, breast cancer HR=1.06, 95% CI 0.94-1.19, p=0.35). Null results were also obtained for associations with overall survival following ovarian cancer (HR=0.94, 95% CI 0.83-1.07, p=0.38), breast cancer (HR=0.96, 95% CI 0.87-1.06, p=0.38), and all other previously-reported associations. CONCLUSIONS: rs61764370 is not associated with risk of ovarian or breast cancer nor with clinical outcome for patients with these cancers. Therefore, genotyping this variant has no clinical utility related to the prediction or management of these cancers. | |
dc.format | Print-Electronic | |
dc.format.extent | 386 - 401 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | |
dc.rights.uri | https://www.rioxx.net/licenses/all-rights-reserved | |
dc.subject | Ovarian Cancer Association Consortium, Breast Cancer Association Consortium, and Consortium of Modifiers of BRCA1 and BRCA2 | |
dc.subject | Australian Ovarian Cancer Study Group | |
dc.subject | Breast Cancer Family Register | |
dc.subject | EMBRACE | |
dc.subject | GEMO Study Collaborators | |
dc.subject | GENICA Network | |
dc.subject | HEBON | |
dc.subject | KConFab Investigators | |
dc.subject | SWE-BRCA | |
dc.subject | Humans | |
dc.subject | Neoplasms, Glandular and Epithelial | |
dc.subject | Breast Neoplasms | |
dc.subject | Ovarian Neoplasms | |
dc.subject | Female | |
dc.subject | Proto-Oncogene Proteins p21(ras) | |
dc.subject | Carcinoma, Ovarian Epithelial | |
dc.title | No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2015-04-19 | |
rioxxterms.versionofrecord | 10.1016/j.ygyno.2015.04.034 | |
rioxxterms.licenseref.uri | https://www.rioxx.net/licenses/all-rights-reserved | |
rioxxterms.licenseref.startdate | 2016-05 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | Gynecologic oncology | |
pubs.issue | 2 | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Complex Trait Genetics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Functional Genetic Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Closed research teams | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Closed research teams/Medicine (Brown Epigenetic Therapy) | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Closed research teams/Molecular Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/Royal Marsden Clinical Units | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Complex Trait Genetics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Functional Genetic Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Closed research teams | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Closed research teams/Medicine (Brown Epigenetic Therapy) | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Closed research teams/Molecular Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/Royal Marsden Clinical Units | |
pubs.publication-status | Published | |
pubs.volume | 141 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Complex Trait Genetics | |
icr.researchteam | Functional Genetic Epidemiology | |
icr.researchteam | Medicine (Brown Epigenetic Therapy) | |
icr.researchteam | Molecular Epidemiology | |
icr.researchteam | Aetiological Epidemiology | |
dc.contributor.icrauthor | Fletcher, Olivia | |
dc.contributor.icrauthor | Schoemaker, Minouk | |
dc.contributor.icrauthor | Swerdlow, Anthony | |