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dc.contributor.authorOvarian Cancer Association Consortium, Breast Cancer Association Consortium, and Consortium of Modifiers of BRCA1 and BRCA2en_US
dc.contributor.authorHollestelle, Aen_US
dc.contributor.authorvan der Baan, FHen_US
dc.contributor.authorBerchuck, Aen_US
dc.contributor.authorJohnatty, SEen_US
dc.contributor.authorAben, KKen_US
dc.contributor.authorAgnarsson, BAen_US
dc.contributor.authorAittomäki, Ken_US
dc.contributor.authorAlducci, Een_US
dc.contributor.authorAndrulis, ILen_US
dc.contributor.authorAnton-Culver, Hen_US
dc.contributor.authorAntonenkova, NNen_US
dc.contributor.authorAntoniou, ACen_US
dc.contributor.authorApicella, Cen_US
dc.contributor.authorArndt, Ven_US
dc.contributor.authorArnold, Nen_US
dc.contributor.authorArun, BKen_US
dc.contributor.authorArver, Ben_US
dc.contributor.authorAshworth, Aen_US
dc.contributor.authorAustralian Ovarian Cancer Study Groupen_US
dc.contributor.authorBaglietto, Len_US
dc.contributor.authorBalleine, Ren_US
dc.contributor.authorBandera, EVen_US
dc.contributor.authorBarrowdale, Den_US
dc.contributor.authorBean, YTen_US
dc.contributor.authorBeckmann, Len_US
dc.contributor.authorBeckmann, MWen_US
dc.contributor.authorBenitez, Jen_US
dc.contributor.authorBerger, Aen_US
dc.contributor.authorBerger, Ren_US
dc.contributor.authorBeuselinck, Ben_US
dc.contributor.authorBisogna, Men_US
dc.contributor.authorBjorge, Len_US
dc.contributor.authorBlomqvist, Cen_US
dc.contributor.authorBogdanova, NVen_US
dc.contributor.authorBojesen, Aen_US
dc.contributor.authorBojesen, SEen_US
dc.contributor.authorBolla, MKen_US
dc.contributor.authorBonanni, Ben_US
dc.contributor.authorBrand, JSen_US
dc.contributor.authorBrauch, Hen_US
dc.contributor.authorBreast Cancer Family Registeren_US
dc.contributor.authorBrenner, Hen_US
dc.contributor.authorBrinton, Len_US
dc.contributor.authorBrooks-Wilson, Aen_US
dc.contributor.authorBruinsma, Fen_US
dc.contributor.authorBrunet, Jen_US
dc.contributor.authorBrüning, Ten_US
dc.contributor.authorBudzilowska, Aen_US
dc.contributor.authorBunker, CHen_US
dc.contributor.authorBurwinkel, Ben_US
dc.contributor.authorButzow, Ren_US
dc.contributor.authorBuys, SSen_US
dc.contributor.authorCaligo, MAen_US
dc.contributor.authorCampbell, Ien_US
dc.contributor.authorCarter, Jen_US
dc.contributor.authorChang-Claude, Jen_US
dc.contributor.authorChanock, SJen_US
dc.contributor.authorClaes, KBMen_US
dc.contributor.authorCollée, JMen_US
dc.contributor.authorCook, LSen_US
dc.contributor.authorCouch, FJen_US
dc.contributor.authorCox, Aen_US
dc.contributor.authorCramer, Den_US
dc.contributor.authorCross, SSen_US
dc.contributor.authorCunningham, JMen_US
dc.contributor.authorCybulski, Cen_US
dc.contributor.authorCzene, Ken_US
dc.contributor.authorDamiola, Fen_US
dc.contributor.authorDansonka-Mieszkowska, Aen_US
dc.contributor.authorDarabi, Hen_US
dc.contributor.authorde la Hoya, Men_US
dc.contributor.authordeFazio, Aen_US
dc.contributor.authorDennis, Jen_US
dc.contributor.authorDevilee, Pen_US
dc.contributor.authorDicks, EMen_US
dc.contributor.authorDiez, Oen_US
dc.contributor.authorDoherty, JAen_US
dc.contributor.authorDomchek, SMen_US
dc.contributor.authorDorfling, CMen_US
dc.contributor.authorDörk, Ten_US
dc.contributor.authorSilva, IDSen_US
dc.contributor.authordu Bois, Aen_US
dc.contributor.authorDumont, Men_US
dc.contributor.authorDunning, AMen_US
dc.contributor.authorDuran, Men_US
dc.contributor.authorEaston, DFen_US
dc.contributor.authorEccles, Den_US
dc.contributor.authorEdwards, RPen_US
dc.contributor.authorEhrencrona, Hen_US
dc.contributor.authorEjlertsen, Ben_US
dc.contributor.authorEkici, ABen_US
dc.contributor.authorEllis, SDen_US
dc.contributor.authorEMBRACEen_US
dc.contributor.authorEngel, Cen_US
dc.contributor.authorEriksson, Men_US
dc.contributor.authorFasching, PAen_US
dc.contributor.authorFeliubadalo, Len_US
dc.contributor.authorFigueroa, Jen_US
dc.contributor.authorFlesch-Janys, Den_US
dc.contributor.authorFletcher, Oen_US
dc.contributor.authorFontaine, Aen_US
dc.contributor.authorFortuzzi, Sen_US
dc.contributor.authorFostira, Fen_US
dc.contributor.authorFridley, BLen_US
dc.contributor.authorFriebel, Ten_US
dc.contributor.authorFriedman, Een_US
dc.contributor.authorFriel, Gen_US
dc.contributor.authorFrost, Den_US
dc.contributor.authorGarber, Jen_US
dc.contributor.authorGarcía-Closas, Men_US
dc.contributor.authorGayther, SAen_US
dc.contributor.authorGEMO Study Collaboratorsen_US
dc.contributor.authorGENICA Networken_US
dc.contributor.authorGentry-Maharaj, Aen_US
dc.contributor.authorGerdes, A-Men_US
dc.contributor.authorGiles, GGen_US
dc.contributor.authorGlasspool, Ren_US
dc.contributor.authorGlendon, Gen_US
dc.contributor.authorGodwin, AKen_US
dc.contributor.authorGoodman, MTen_US
dc.contributor.authorGore, Men_US
dc.contributor.authorGreene, MHen_US
dc.contributor.authorGrip, Men_US
dc.contributor.authorGronwald, Jen_US
dc.contributor.authorGschwantler Kaulich, Den_US
dc.contributor.authorGuénel, Pen_US
dc.contributor.authorGuzman, SRen_US
dc.contributor.authorHaeberle, Len_US
dc.contributor.authorHaiman, CAen_US
dc.contributor.authorHall, Pen_US
dc.contributor.authorHalverson, SLen_US
dc.contributor.authorHamann, Uen_US
dc.contributor.authorHansen, TVOen_US
dc.contributor.authorHarter, Pen_US
dc.contributor.authorHartikainen, JMen_US
dc.contributor.authorHealey, Sen_US
dc.contributor.authorHEBONen_US
dc.contributor.authorHein, Aen_US
dc.contributor.authorHeitz, Fen_US
dc.contributor.authorHenderson, BEen_US
dc.contributor.authorHerzog, Jen_US
dc.contributor.authorT Hildebrandt, MAen_US
dc.contributor.authorHøgdall, CKen_US
dc.contributor.authorHøgdall, Een_US
dc.contributor.authorHogervorst, FBLen_US
dc.contributor.authorHopper, JLen_US
dc.contributor.authorHumphreys, Ken_US
dc.contributor.authorHuzarski, Ten_US
dc.contributor.authorImyanitov, ENen_US
dc.contributor.authorIsaacs, Cen_US
dc.contributor.authorJakubowska, Aen_US
dc.contributor.authorJanavicius, Ren_US
dc.contributor.authorJaworska, Ken_US
dc.contributor.authorJensen, Aen_US
dc.contributor.authorJensen, UBen_US
dc.contributor.authorJohnson, Nen_US
dc.contributor.authorJukkola-Vuorinen, Aen_US
dc.contributor.authorKabisch, Men_US
dc.contributor.authorKarlan, BYen_US
dc.contributor.authorKataja, Ven_US
dc.contributor.authorKauff, Nen_US
dc.contributor.authorKConFab Investigatorsen_US
dc.contributor.authorKelemen, LEen_US
dc.contributor.authorKerin, MJen_US
dc.contributor.authorKiemeney, LAen_US
dc.contributor.authorKjaer, SKen_US
dc.contributor.authorKnight, JAen_US
dc.contributor.authorKnol-Bout, JPen_US
dc.contributor.authorKonstantopoulou, Ien_US
dc.contributor.authorKosma, V-Men_US
dc.contributor.authorKrakstad, Cen_US
dc.contributor.authorKristensen, Ven_US
dc.contributor.authorKuchenbaecker, KBen_US
dc.contributor.authorKupryjanczyk, Jen_US
dc.contributor.authorLaitman, Yen_US
dc.contributor.authorLambrechts, Den_US
dc.contributor.authorLambrechts, Sen_US
dc.contributor.authorLarson, MCen_US
dc.contributor.authorLasa, Aen_US
dc.contributor.authorLaurent-Puig, Pen_US
dc.contributor.authorLazaro, Cen_US
dc.contributor.authorLe, NDen_US
dc.contributor.authorLe Marchand, Len_US
dc.contributor.authorLeminen, Aen_US
dc.contributor.authorLester, Jen_US
dc.contributor.authorLevine, DAen_US
dc.contributor.authorLi, Jen_US
dc.contributor.authorLiang, Den_US
dc.contributor.authorLindblom, Aen_US
dc.contributor.authorLindor, Nen_US
dc.contributor.authorLissowska, Jen_US
dc.contributor.authorLong, Jen_US
dc.contributor.authorLu, KHen_US
dc.contributor.authorLubinski, Jen_US
dc.contributor.authorLundvall, Len_US
dc.contributor.authorLurie, Gen_US
dc.contributor.authorMai, PLen_US
dc.contributor.authorMannermaa, Aen_US
dc.contributor.authorMargolin, Sen_US
dc.contributor.authorMariette, Fen_US
dc.contributor.authorMarme, Fen_US
dc.contributor.authorMartens, JWMen_US
dc.contributor.authorMassuger, LFAGen_US
dc.contributor.authorMaugard, Cen_US
dc.contributor.authorMazoyer, Sen_US
dc.contributor.authorMcGuffog, Len_US
dc.contributor.authorMcGuire, Ven_US
dc.contributor.authorMcLean, Cen_US
dc.contributor.authorMcNeish, Ien_US
dc.contributor.authorMeindl, Aen_US
dc.contributor.authorMenegaux, Fen_US
dc.contributor.authorMenéndez, Pen_US
dc.contributor.authorMenkiszak, Jen_US
dc.contributor.authorMenon, Uen_US
dc.contributor.authorMensenkamp, ARen_US
dc.contributor.authorMiller, Nen_US
dc.contributor.authorMilne, RLen_US
dc.contributor.authorModugno, Fen_US
dc.contributor.authorMontagna, Men_US
dc.contributor.authorMoysich, KBen_US
dc.contributor.authorMüller, Hen_US
dc.contributor.authorMulligan, AMen_US
dc.contributor.authorMuranen, TAen_US
dc.contributor.authorNarod, SAen_US
dc.contributor.authorNathanson, KLen_US
dc.contributor.authorNess, RBen_US
dc.contributor.authorNeuhausen, SLen_US
dc.contributor.authorNevanlinna, Hen_US
dc.contributor.authorNeven, Pen_US
dc.contributor.authorNielsen, FCen_US
dc.contributor.authorNielsen, SFen_US
dc.contributor.authorNordestgaard, BGen_US
dc.contributor.authorNussbaum, RLen_US
dc.contributor.authorOdunsi, Ken_US
dc.contributor.authorOffit, Ken_US
dc.contributor.authorOlah, Een_US
dc.contributor.authorOlopade, OIen_US
dc.contributor.authorOlson, JEen_US
dc.contributor.authorOlson, SHen_US
dc.contributor.authorOosterwijk, JCen_US
dc.contributor.authorOrlow, Ien_US
dc.contributor.authorOrr, Nen_US
dc.contributor.authorOrsulic, Sen_US
dc.contributor.authorOsorio, Aen_US
dc.contributor.authorOttini, Len_US
dc.contributor.authorPaul, Jen_US
dc.contributor.authorPearce, CLen_US
dc.contributor.authorPedersen, ISen_US
dc.contributor.authorPeissel, Ben_US
dc.contributor.authorPejovic, Ten_US
dc.contributor.authorPelttari, LMen_US
dc.contributor.authorPerkins, Jen_US
dc.contributor.authorPermuth-Wey, Jen_US
dc.contributor.authorPeterlongo, Pen_US
dc.contributor.authorPeto, Jen_US
dc.contributor.authorPhelan, CMen_US
dc.contributor.authorPhillips, K-Aen_US
dc.contributor.authorPiedmonte, Men_US
dc.contributor.authorPike, MCen_US
dc.contributor.authorPlatte, Ren_US
dc.contributor.authorPlisiecka-Halasa, Jen_US
dc.contributor.authorPoole, EMen_US
dc.contributor.authorPoppe, Ben_US
dc.contributor.authorPylkäs, Ken_US
dc.contributor.authorRadice, Pen_US
dc.contributor.authorRamus, SJen_US
dc.contributor.authorRebbeck, TRen_US
dc.contributor.authorReed, MWRen_US
dc.contributor.authorRennert, Gen_US
dc.contributor.authorRisch, HAen_US
dc.contributor.authorRobson, Men_US
dc.contributor.authorRodriguez, GCen_US
dc.contributor.authorRomero, Aen_US
dc.contributor.authorRossing, MAen_US
dc.contributor.authorRothstein, JHen_US
dc.contributor.authorRudolph, Aen_US
dc.contributor.authorRunnebaum, Ien_US
dc.contributor.authorSalani, Ren_US
dc.contributor.authorSalvesen, HBen_US
dc.contributor.authorSawyer, EJen_US
dc.contributor.authorSchildkraut, JMen_US
dc.contributor.authorSchmidt, MKen_US
dc.contributor.authorSchmutzler, RKen_US
dc.contributor.authorSchneeweiss, Aen_US
dc.contributor.authorSchoemaker, MJen_US
dc.contributor.authorSchrauder, MGen_US
dc.contributor.authorSchumacher, Fen_US
dc.contributor.authorSchwaab, Ien_US
dc.contributor.authorScuvera, Gen_US
dc.contributor.authorSellers, TAen_US
dc.contributor.authorSeveri, Gen_US
dc.contributor.authorSeynaeve, CMen_US
dc.contributor.authorShah, Men_US
dc.contributor.authorShrubsole, Men_US
dc.contributor.authorSiddiqui, Nen_US
dc.contributor.authorSieh, Wen_US
dc.contributor.authorSimard, Jen_US
dc.contributor.authorSinger, CFen_US
dc.contributor.authorSinilnikova, OMen_US
dc.contributor.authorSmeets, Den_US
dc.contributor.authorSohn, Cen_US
dc.contributor.authorSoller, Men_US
dc.contributor.authorSong, Hen_US
dc.contributor.authorSoucy, Pen_US
dc.contributor.authorSouthey, MCen_US
dc.contributor.authorStegmaier, Cen_US
dc.contributor.authorStoppa-Lyonnet, Den_US
dc.contributor.authorSucheston, Len_US
dc.contributor.authorSWE-BRCAen_US
dc.contributor.authorSwerdlow, Aen_US
dc.contributor.authorTangen, ILen_US
dc.contributor.authorTea, M-Ken_US
dc.contributor.authorTeixeira, MRen_US
dc.contributor.authorTerry, KLen_US
dc.contributor.authorTerry, MBen_US
dc.contributor.authorThomassen, Men_US
dc.contributor.authorThompson, PJen_US
dc.contributor.authorTihomirova, Len_US
dc.contributor.authorTischkowitz, Men_US
dc.contributor.authorToland, AEen_US
dc.contributor.authorTollenaar, RAEMen_US
dc.contributor.authorTomlinson, Ien_US
dc.contributor.authorTorres, Den_US
dc.contributor.authorTruong, Ten_US
dc.contributor.authorTsimiklis, Hen_US
dc.contributor.authorTung, Nen_US
dc.contributor.authorTworoger, SSen_US
dc.contributor.authorTyrer, JPen_US
dc.contributor.authorVachon, CMen_US
dc.contributor.authorVan 't Veer, LJen_US
dc.contributor.authorvan Altena, AMen_US
dc.contributor.authorVan Asperen, CJen_US
dc.contributor.authorvan den Berg, Den_US
dc.contributor.authorvan den Ouweland, AMWen_US
dc.contributor.authorvan Doorn, HCen_US
dc.contributor.authorVan Nieuwenhuysen, Een_US
dc.contributor.authorvan Rensburg, EJen_US
dc.contributor.authorVergote, Ien_US
dc.contributor.authorVerhoef, Sen_US
dc.contributor.authorVierkant, RAen_US
dc.contributor.authorVijai, Jen_US
dc.contributor.authorVitonis, AFen_US
dc.contributor.authorvon Wachenfeldt, Aen_US
dc.contributor.authorWalsh, Cen_US
dc.contributor.authorWang, Qen_US
dc.contributor.authorWang-Gohrke, Sen_US
dc.contributor.authorWappenschmidt, Ben_US
dc.contributor.authorWeischer, Men_US
dc.contributor.authorWeitzel, JNen_US
dc.contributor.authorWeltens, Cen_US
dc.contributor.authorWentzensen, Nen_US
dc.contributor.authorWhittemore, ASen_US
dc.contributor.authorWilkens, LRen_US
dc.contributor.authorWinqvist, Ren_US
dc.contributor.authorWu, AHen_US
dc.contributor.authorWu, Xen_US
dc.contributor.authorYang, HPen_US
dc.contributor.authorZaffaroni, Den_US
dc.contributor.authorPilar Zamora, Men_US
dc.contributor.authorZheng, Wen_US
dc.contributor.authorZiogas, Aen_US
dc.contributor.authorChenevix-Trench, Gen_US
dc.contributor.authorPharoah, PDPen_US
dc.contributor.authorRookus, MAen_US
dc.contributor.authorHooning, MJen_US
dc.contributor.authorGoode, ELen_US
dc.date.accessioned2017-04-03T09:39:30Z
dc.date.issued2016-05en_US
dc.identifier.citationGynecologic oncology, 2016, 141 (2), pp. 386 - 401en_US
dc.identifier.issn0090-8258en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/540
dc.identifier.eissn1095-6859en_US
dc.identifier.doi10.1016/j.ygyno.2015.04.034en_US
dc.description.abstract<h4>Objective</h4>Clinical genetic testing is commercially available for rs61764370, an inherited variant residing in a KRAS 3' UTR microRNA binding site, based on suggested associations with increased ovarian and breast cancer risk as well as with survival time. However, prior studies, emphasizing particular subgroups, were relatively small. Therefore, we comprehensively evaluated ovarian and breast cancer risks as well as clinical outcome associated with rs61764370.<h4>Methods</h4>Centralized genotyping and analysis were performed for 140,012 women enrolled in the Ovarian Cancer Association Consortium (15,357 ovarian cancer patients; 30,816 controls), the Breast Cancer Association Consortium (33,530 breast cancer patients; 37,640 controls), and the Consortium of Modifiers of BRCA1 and BRCA2 (14,765 BRCA1 and 7904 BRCA2 mutation carriers).<h4>Results</h4>We found no association with risk of ovarian cancer (OR=0.99, 95% CI 0.94-1.04, p=0.74) or breast cancer (OR=0.98, 95% CI 0.94-1.01, p=0.19) and results were consistent among mutation carriers (BRCA1, ovarian cancer HR=1.09, 95% CI 0.97-1.23, p=0.14, breast cancer HR=1.04, 95% CI 0.97-1.12, p=0.27; BRCA2, ovarian cancer HR=0.89, 95% CI 0.71-1.13, p=0.34, breast cancer HR=1.06, 95% CI 0.94-1.19, p=0.35). Null results were also obtained for associations with overall survival following ovarian cancer (HR=0.94, 95% CI 0.83-1.07, p=0.38), breast cancer (HR=0.96, 95% CI 0.87-1.06, p=0.38), and all other previously-reported associations.<h4>Conclusions</h4>rs61764370 is not associated with risk of ovarian or breast cancer nor with clinical outcome for patients with these cancers. Therefore, genotyping this variant has no clinical utility related to the prediction or management of these cancers.en_US
dc.formatPrint-Electronicen_US
dc.format.extent386 - 401en_US
dc.languageengen_US
dc.language.isoengen_US
dc.rights.urihttp://www.rioxx.net/licenses/all-rights-reserveden_US
dc.subjectOvarian Cancer Association Consortium, Breast Cancer Association Consortium, and Consortium of Modifiers of BRCA1 and BRCA2en_US
dc.subjectAustralian Ovarian Cancer Study Groupen_US
dc.subjectBreast Cancer Family Registeren_US
dc.subjectEMBRACEen_US
dc.subjectGEMO Study Collaboratorsen_US
dc.subjectGENICA Networken_US
dc.subjectHEBONen_US
dc.subjectKConFab Investigatorsen_US
dc.subjectSWE-BRCAen_US
dc.subjectHumansen_US
dc.subjectNeoplasms, Glandular and Epithelialen_US
dc.subjectBreast Neoplasmsen_US
dc.subjectOvarian Neoplasmsen_US
dc.subjectFemaleen_US
dc.subjectProto-Oncogene Proteins p21(ras)en_US
dc.subjectCarcinoma, Ovarian Epithelialen_US
dc.titleNo clinical utility of KRAS variant rs61764370 for ovarian or breast cancer.en_US
dc.typeJournal Article
dcterms.dateAccepted2015-04-19en_US
rioxxterms.versionofrecord10.1016/j.ygyno.2015.04.034en_US
rioxxterms.licenseref.startdate2016-05en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfGynecologic oncologyen_US
pubs.issue2en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Complex Trait Genetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Functional Genetic Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams/Medicine (Brown Epigenetic Therapy)
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams/Molecular Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.publication-statusPublisheden_US
pubs.volume141en_US
pubs.embargo.termsNot knownen_US
icr.researchteamComplex Trait Geneticsen_US
icr.researchteamFunctional Genetic Epidemiologyen_US
icr.researchteamMedicine (Brown Epigenetic Therapy)en_US
icr.researchteamMolecular Epidemiologyen_US
icr.researchteamAetiological Epidemiologyen_US
dc.contributor.icrauthorSwerdlow, Anthonyen_US
dc.contributor.icrauthorSchoemaker, Minouken_US
dc.contributor.icrauthorFletcher, Oliviaen_US
dc.contributor.icrauthorOrr, Nicholasen_US
dc.contributor.icrauthorGore, Martinen_US
dc.contributor.icrauthorGarcia-Closas, Montserraten_US
dc.contributor.icrauthorBrown, Roberten_US


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