The psychosocial impact of prostate cancer screening for BRCA1 and BRCA2 carriers.
Date
2024-06-05Author
Bancroft, EK
Page, EC
Brook, MN
Pope, J
Thomas, S
Myhill, K
Helfand, BT
Talaty, P
Ong, K-R
Douglas, E
Cook, J
Rosario, DJ
Salinas, M
Buys, SS
Anson, J
Davidson, R
Longmuir, M
Side, L
Eccles, DM
Tischkowitz, M
Taylor, A
Cruellas, M
Ballestero, EP
Cleaver, R
Varughese, M
Barwell, J
LeButt, M
Greenhalgh, L
Hart, R
Azzabi, A
Jobson, I
Cogley, L
Evans, DG
Rothwell, J
Taylor, N
Hogben, M
Saya, S
IMPACT Study Steering Committee; IMPACT Collaborators,
Eeles, RA
Aaronson, NK
Type
Journal Article
Metadata
Show full item recordAbstract
OBJECTIVES: To report the long-term outcomes from a longitudinal psychosocial study that forms part of the 'Identification of Men with a genetic predisposition to ProstAte Cancer: Targeted Screening in men at higher genetic risk and controls' (IMPACT) study. The IMPACT study is a multi-national study of targeted prostate cancer (PrCa) screening in individuals with a known germline pathogenic variant (GPV) in either the BReast CAncer gene 1 (BRCA1) or the BReast CAncer gene 2 (BRCA2). SUBJECTS AND METHODS: Participants enrolled in the IMPACT study were invited to complete a psychosocial questionnaire prior to each annual screening visit for a minimum of 5 years. The questionnaire included questions on sociodemographics and the following measures: Hospital Anxiety and Depression Scale, Impact of Event Scale, 36-item Short-Form Health Survey, Memorial Anxiety Scale for PrCa, Cancer Worry Scale, risk perception and knowledge. RESULTS: A total of 760 participants completed questionnaires: 207 participants with GPV in BRCA1, 265 with GPV in BRCA2 and 288 controls (non-carriers from families with a known GPV). We found no evidence of clinically concerning levels of general or cancer-specific distress or poor health-related quality of life in the cohort as a whole. Individuals in the control group had significantly less worry about PrCa compared with the carriers; however, all mean scores were low and within reported general population norms, where available. BRCA2 carriers with previously high prostate-specific antigen (PSA) levels experience a small but significant increase in PrCa anxiety (P = 0.01) and PSA-specific anxiety (P < 0.001). Cancer risk perceptions reflected information provided during genetic counselling and participants had good levels of knowledge, although this declined over time. CONCLUSION: This is the first study to report the longitudinal psychosocial impact of a targeted PrCa screening programme for BRCA1 and BRCA2 carriers. The results reassure that an annual PSA-based screening programme does not have an adverse impact on psychosocial health or health-related quality of life in these higher-risk individuals. These results are important as more PrCa screening is targeted to higher-risk groups.
Collections
Subject
BRCA1
BRCA2
genetic screening
prostate cancer
psychosocial
quality of life
Research team
Oncogenetics
Language
eng
Date accepted
2024-06-05
License start date
2024-06-05
Citation
BJU International, 2024,
Publisher
WILEY