dc.contributor.author | Webster, A | |
dc.contributor.author | Francis, M | |
dc.contributor.author | Gribble, H | |
dc.contributor.author | Griffin, C | |
dc.contributor.author | Hafeez, S | |
dc.contributor.author | Hansen, VN | |
dc.contributor.author | Lewis, R | |
dc.contributor.author | McNair, H | |
dc.contributor.author | Miles, E | |
dc.contributor.author | Hall, E | |
dc.contributor.author | Huddart, R | |
dc.contributor.author | RAIDER Trial Management Group, | |
dc.coverage.spatial | Ireland | |
dc.date.accessioned | 2024-08-09T11:16:55Z | |
dc.date.available | 2024-08-09T11:16:55Z | |
dc.date.issued | 2024-07-26 | |
dc.identifier | 110460 | |
dc.identifier | S0167-8140(24)00730-8 | |
dc.identifier.citation | Radiotherapy and Oncology, 2024, pp. 110460 - | |
dc.identifier.issn | 0167-8140 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/6348 | |
dc.identifier.eissn | 1879-0887 | |
dc.identifier.eissn | 1879-0887 | |
dc.identifier.doi | 10.1016/j.radonc.2024.110460 | |
dc.identifier.doi | 10.1016/j.radonc.2024.110460 | |
dc.description.abstract | BACKGROUND AND PURPOSE: Radiotherapy trial quality assurance (RT QA) is crucial for ensuring the safe and reliable delivery of radiotherapy trials, and minimizing inter-institutional variations. While previous studies focused on outlining and planning quality assurance (QA), this work explores the process of Image-Guided Radiotherapy (IGRT), and adaptive radiotherapy. This study presents findings from during-accrual QA in the RAIDER trial, evaluating concordance between online and offline plan selections for bladder cancer participants undergoing adaptive radiotherapy. RAIDER had two seamless stages; stage 1 assessed adherence to dose constraints of dose escalated radiotherapy (DART) and stage 2 assessed safety. The RT QA programme was updated from stage 1 to stage 2. MATERIALS AND METHODS: Data from all participants in the adaptive arms (standard dose adaptive radiotherapy (SART) and DART) of the trial was requested (33 centres across the UK, Australia and New Zealand). Data collection spanned September 2015 to December 2022 and included the plans selected online, on Cone-Beam Computed Tomography (CBCT) data. Concordance with the plans selected offline by the independent RT QA central reviewer was evaluated. RESULTS: Analysable data was received for 72 participants, giving a total of 884 CBCTs. The overall concordance rate was 83% (723/884). From stage 1 to stage 2 the concordance in the plans selected improved from 75% (369/495) to 91% (354/389). CONCLUSION: During-accrual IGRT QA positively influenced plan selection concordance, highlighting the need for ongoing support when introducing a new technique. Overall, it contributes to advancing the understanding and implementation of QA measures in adaptive radiotherapy trials. | |
dc.format | Print-Electronic | |
dc.format.extent | 110460 - | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | ELSEVIER IRELAND LTD | |
dc.relation.ispartof | Radiotherapy and Oncology | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | Adaptive | |
dc.subject | Bladder cancer | |
dc.subject | IGRT | |
dc.subject | Plan selection | |
dc.subject | Quality assurance | |
dc.title | Impact of on-trial IGRT quality assurance in an international adaptive radiotherapy trial for participants with bladder cancer. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2024-07-20 | |
dc.date.updated | 2024-08-08T09:25:11Z | |
rioxxterms.version | VoR | |
rioxxterms.versionofrecord | 10.1016/j.radonc.2024.110460 | |
rioxxterms.licenseref.startdate | 2024-07-26 | |
rioxxterms.type | Journal Article/Review | |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/39069085 | |
pubs.organisational-group | ICR | |
pubs.organisational-group | ICR/Primary Group | |
pubs.organisational-group | ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | ICR/Primary Group/ICR Divisions/Clinical Studies | |
pubs.organisational-group | ICR/Primary Group/ICR Divisions/Clinical Studies/Clinical Trials & Statistics Unit | |
pubs.organisational-group | ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Clinical Academic Radiotherapy (Huddart) | |
pubs.publication-status | Published online | |
pubs.publisher-url | http://dx.doi.org/10.1016/j.radonc.2024.110460 | |
icr.researchteam | Clinic Acad RT Huddart | |
icr.researchteam | Clin Trials & Stats Unit | |
dc.contributor.icrauthor | Hafeez, Shaista | |
dc.contributor.icrauthor | Lewis, Rebecca | |
dc.contributor.icrauthor | Hall, Emma | |
dc.contributor.icrauthor | Huddart, Robert | |
icr.provenance | Deposited by Ms Jessica Phelps (impersonating Prof Emma Hall) on 2024-08-08. Deposit type is initial. No. of files: 1. Files: Impact of on-trial IGRT quality assurance in an international adaptive radiotherapy trial for participants with bladder cancer..pdf | |