dc.contributor.author | Cheang, MCU | |
dc.contributor.author | Rimawi, M | |
dc.contributor.author | Johnston, S | |
dc.contributor.author | Jacobs, SA | |
dc.contributor.author | Bliss, J | |
dc.contributor.author | Pogue-Geile, K | |
dc.contributor.author | Kilburn, L | |
dc.contributor.author | Zhu, Z | |
dc.contributor.author | Schuster, EF | |
dc.contributor.author | Xiao, H | |
dc.contributor.author | Swaim, L | |
dc.contributor.author | Deng, S | |
dc.contributor.author | Lu, DR | |
dc.contributor.author | Gauthier, E | |
dc.contributor.author | Tursi, J | |
dc.contributor.author | Slamon, DJ | |
dc.contributor.author | Rugo, HS | |
dc.contributor.author | Finn, RS | |
dc.contributor.author | Liu, Y | |
dc.coverage.spatial | United States | |
dc.date.accessioned | 2024-08-09T11:17:14Z | |
dc.date.available | 2024-08-09T11:17:14Z | |
dc.date.issued | 2024-06-29 | |
dc.identifier | ARTN 54 | |
dc.identifier | 10.1038/s41523-024-00658-y | |
dc.identifier.citation | npj Breast Cancer, 2024, 10 (1), pp. 54 - | en_US |
dc.identifier.issn | 2374-4677 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/6351 | |
dc.identifier.eissn | 2374-4677 | |
dc.identifier.eissn | 2374-4677 | |
dc.identifier.doi | 10.1038/s41523-024-00658-y | |
dc.identifier.doi | 10.1038/s41523-024-00658-y | |
dc.description.abstract | Intrinsic breast cancer molecular subtyping (IBCMS) provides significant prognostic information for patients with breast cancer and helps determine treatment. This study compared IBCMS methods on various gene-expression platforms in PALOMA-2 and PALLET trials. PALOMA-2 tumor samples were profiled using EdgeSeq and nanostring and subtyped with AIMS, PAM50, and research-use-only (ruo)Prosigna. PALLET tumor biopsies were profiled using mRNA sequencing and subtyped with AIMS and PAM50. In PALOMA-2 (n = 222), a 54% agreement was observed between results from AIMS and gold-standard ruoProsigna, with AIMS assigning 67% basal-like to HER2-enriched. In PALLET (n = 224), a 69% agreement was observed between results from PAM50 and AIMS. Different IBCMS methods may lead to different results and could misguide treatment selection; hence, a standardized clinical PAM50 assay and computational approach should be used.Trial number: NCT01740427. | |
dc.format | Electronic | |
dc.format.extent | 54 - | |
dc.language | eng | |
dc.language.iso | eng | en_US |
dc.publisher | NATURE PORTFOLIO | en_US |
dc.relation.ispartof | npj Breast Cancer | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en_US |
dc.subject | Science & Technology | |
dc.subject | Life Sciences & Biomedicine | |
dc.subject | Oncology | |
dc.subject | DISTANT RECURRENCE | |
dc.subject | PAM50 RISK | |
dc.subject | TRIAL | |
dc.subject | TRASTUZUMAB | |
dc.subject | PREDICTOR | |
dc.subject | SCORE | |
dc.title | Effect of cross-platform gene-expression, computational methods on breast cancer subtyping in PALOMA-2 and PALLET studies. | en_US |
dc.type | Journal Article | |
dcterms.dateAccepted | 2024-06-14 | |
dc.date.updated | 2024-08-08T10:20:00Z | |
rioxxterms.version | VoR | en_US |
rioxxterms.versionofrecord | 10.1038/s41523-024-00658-y | en_US |
rioxxterms.licenseref.startdate | 2024-06-29 | |
rioxxterms.type | Journal Article/Review | en_US |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/38951507 | |
pubs.issue | 1 | |
pubs.organisational-group | ICR | |
pubs.organisational-group | ICR/Primary Group | |
pubs.organisational-group | ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | ICR/Primary Group/ICR Divisions/Clinical Studies | |
pubs.organisational-group | ICR/Primary Group/ICR Divisions/Clinical Studies/Clinical Trials & Statistics Unit | |
pubs.publication-status | Published online | |
pubs.publisher-url | http://dx.doi.org/10.1038/s41523-024-00658-y | |
pubs.volume | 10 | |
icr.researchteam | Clin Trials & Stats Unit | en_US |
dc.contributor.icrauthor | Cheang, Chon | |
dc.contributor.icrauthor | Bliss, Judith | |
dc.contributor.icrauthor | Kilburn, Lucy | |
icr.provenance | Deposited by Ms Jessica Phelps (impersonating Prof Judith Bliss) on 2024-08-08. Deposit type is initial. No. of files: 1. Files: Effect of cross-platform gene-expression, computational methods on breast cancer subtyping in PALOMA-2 and PALLET studies.pdf | |