Proteomic features of soft tissue tumours in adolescents and young adults.
Date
2024-05-18Author
Tam, YB
Low, K
Ps, H
Chadha, M
Burns, J
Wilding, CP
Arthur, A
Chen, TW
Thway, K
Sadanandam, A
Jones, RL
Huang, PH
Type
Journal Article
Metadata
Show full item recordAbstract
BACKGROUND: Adolescents and young adult (AYA) patients with soft tissue tumours including sarcomas are an underserved group with disparities in treatment outcomes. METHODS: To define the molecular features between AYA and older adult (OA) patients, we analysed the proteomic profiles of a large cohort of soft tissue tumours across 10 histological subtypes (AYA n = 66, OA n = 243), and also analysed publicly available functional genomic data from soft tissue tumour cell lines (AYA n = 5, OA n = 8). RESULTS: Biological hallmarks analysis demonstrates that OA tumours are significantly enriched in MYC targets compared to AYA tumours. By comparing the patient-level proteomic data with functional genomic profiles from sarcoma cell lines, we show that the mRNA splicing pathway is an intrinsic vulnerability in cell lines from OA patients and that components of the spliceosome complex are independent prognostic factors for metastasis free survival in AYA patients. CONCLUSIONS: Our study highlights the importance of performing age-specific molecular profiling studies to identify risk stratification tools and targeted agents tailored for the clinical management of AYA patients.
Collections
Subject
Science & Technology
Life Sciences & Biomedicine
Medicine, Research & Experimental
Research & Experimental Medicine
PROTEOGENOMIC CHARACTERIZATION
PROGNOSTIC-FACTORS
GENE-EXPRESSION
CANCER
SARCOMAS
SURVIVAL
OUTCOMES
MODEL
Research team
Mol and Systems Oncology
Systems - Precision Med
Language
eng
Date accepted
2024-05-07
License start date
2024-05-18
Citation
Communications Medicine, 2024, 4 (1), pp. 93 -
Publisher
SPRINGERNATURE