dc.contributor.author | Tam, YB | |
dc.contributor.author | Low, K | |
dc.contributor.author | Ps, H | |
dc.contributor.author | Chadha, M | |
dc.contributor.author | Burns, J | |
dc.contributor.author | Wilding, CP | |
dc.contributor.author | Arthur, A | |
dc.contributor.author | Chen, TW | |
dc.contributor.author | Thway, K | |
dc.contributor.author | Sadanandam, A | |
dc.contributor.author | Jones, RL | |
dc.contributor.author | Huang, PH | |
dc.coverage.spatial | England | |
dc.date.accessioned | 2024-08-16T09:28:05Z | |
dc.date.available | 2024-08-16T09:28:05Z | |
dc.date.issued | 2024-05-18 | |
dc.identifier | ARTN 93 | |
dc.identifier | 10.1038/s43856-024-00522-x | |
dc.identifier.citation | Communications Medicine, 2024, 4 (1), pp. 93 - | en_US |
dc.identifier.issn | 2730-664X | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/6358 | |
dc.identifier.eissn | 2730-664X | |
dc.identifier.eissn | 2730-664X | |
dc.identifier.doi | 10.1038/s43856-024-00522-x | |
dc.identifier.doi | 10.1038/s43856-024-00522-x | |
dc.description.abstract | BACKGROUND: Adolescents and young adult (AYA) patients with soft tissue tumours including sarcomas are an underserved group with disparities in treatment outcomes. METHODS: To define the molecular features between AYA and older adult (OA) patients, we analysed the proteomic profiles of a large cohort of soft tissue tumours across 10 histological subtypes (AYA n = 66, OA n = 243), and also analysed publicly available functional genomic data from soft tissue tumour cell lines (AYA n = 5, OA n = 8). RESULTS: Biological hallmarks analysis demonstrates that OA tumours are significantly enriched in MYC targets compared to AYA tumours. By comparing the patient-level proteomic data with functional genomic profiles from sarcoma cell lines, we show that the mRNA splicing pathway is an intrinsic vulnerability in cell lines from OA patients and that components of the spliceosome complex are independent prognostic factors for metastasis free survival in AYA patients. CONCLUSIONS: Our study highlights the importance of performing age-specific molecular profiling studies to identify risk stratification tools and targeted agents tailored for the clinical management of AYA patients. | |
dc.format | Electronic | |
dc.format.extent | 93 - | |
dc.language | eng | |
dc.language.iso | eng | en_US |
dc.publisher | SPRINGERNATURE | en_US |
dc.relation.ispartof | Communications Medicine | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en_US |
dc.subject | Science & Technology | |
dc.subject | Life Sciences & Biomedicine | |
dc.subject | Medicine, Research & Experimental | |
dc.subject | Research & Experimental Medicine | |
dc.subject | PROTEOGENOMIC CHARACTERIZATION | |
dc.subject | PROGNOSTIC-FACTORS | |
dc.subject | GENE-EXPRESSION | |
dc.subject | CANCER | |
dc.subject | SARCOMAS | |
dc.subject | SURVIVAL | |
dc.subject | OUTCOMES | |
dc.subject | MODEL | |
dc.title | Proteomic features of soft tissue tumours in adolescents and young adults. | en_US |
dc.type | Journal Article | |
dcterms.dateAccepted | 2024-05-07 | |
dc.date.updated | 2024-08-16T09:26:28Z | |
rioxxterms.version | VoR | en_US |
rioxxterms.versionofrecord | 10.1038/s43856-024-00522-x | en_US |
rioxxterms.licenseref.startdate | 2024-05-18 | |
rioxxterms.type | Journal Article/Review | en_US |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/38762630 | |
pubs.issue | 1 | |
pubs.organisational-group | ICR | |
pubs.organisational-group | ICR/Primary Group | |
pubs.organisational-group | ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | ICR/Primary Group/ICR Divisions/Molecular Pathology/Systems and Precision Cancer Medicine | |
pubs.organisational-group | ICR/Primary Group/ICR Divisions/Molecular Pathology/Molecular and Systems Oncology | |
pubs.organisational-group | ICR/Students | |
pubs.organisational-group | ICR/Students/PhD and MPhil | |
pubs.organisational-group | ICR/Students/PhD and MPhil/19/20 Starting Cohort | |
pubs.organisational-group | ICR/Students/PhD and MPhil/20/21 Starting Cohort | |
pubs.organisational-group | ICR/ImmNet | |
pubs.publication-status | Published online | |
pubs.publisher-url | http://dx.doi.org/10.1038/s43856-024-00522-x | |
pubs.volume | 4 | |
icr.researchteam | Mol and Systems Oncology | en_US |
icr.researchteam | Systems - Precision Med | en_US |
dc.contributor.icrauthor | Tam, Yuen Bun | |
dc.contributor.icrauthor | Chadha, Madhumeeta | |
dc.contributor.icrauthor | Huang, Paul | |
icr.provenance | Deposited by Mr Arek Surman on 2024-08-16. Deposit type is initial. No. of files: 1. Files: Proteomic features of soft tissue tumours in adolescents and young adults.pdf | |