dc.contributor.author | Van Zyl, M | |
dc.contributor.author | Barell, A | |
dc.contributor.author | Cooley, B | |
dc.contributor.author | Hanwell, J | |
dc.contributor.author | Parlak, J | |
dc.contributor.author | Banerji, U | |
dc.contributor.author | De Bono, J | |
dc.contributor.author | Sharp, A | |
dc.contributor.author | Lopez, J | |
dc.contributor.author | Battisti, NML | |
dc.contributor.author | Minchom, A | |
dc.coverage.spatial | United States | |
dc.date.accessioned | 2024-08-30T10:30:33Z | |
dc.date.available | 2024-08-30T10:30:33Z | |
dc.date.issued | 2024-06-01 | |
dc.identifier | ARTN e2083 | |
dc.identifier.citation | Cancer Reports, 2024, 7 (6), pp. e2083 - | en_US |
dc.identifier.issn | 2573-8348 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/6371 | |
dc.identifier.eissn | 2573-8348 | |
dc.identifier.eissn | 2573-8348 | |
dc.identifier.doi | 10.1002/cnr2.2083 | |
dc.identifier.doi | 10.1002/cnr2.2083 | |
dc.description.abstract | BACKGROUND: Though cancer is more prevalent in the older population, this patient group are underrepresented in phase I oncology trials. AIMS: We evaluated the use of a geriatric screening tool (SAOP3) in patients of 70 years of age or older who attended a Phase I Clinical Trials Unit, with the aim of assessing the feasibility of the tool and identifying potential unmet needs in this patient group. METHODS: Twenty-two patients over the age of 70 completed the SAOP3 questionnaire. Geriatric impairments and needs were analysed with descriptive statistics. Qualitative responses were grouped in themes using structured thematic analysis. RESULTS: All of patients triggered at least 1 geriatric domain, most commonly mobility. Six core themes were identified as being important to the patient including family, friends and positivity. On cognition assessment over 20% of patients triggered as requiring further cognitive assessment. The group had a relatively high screen fail risk. CONCLUSION: In conclusion, routine geriatric screening withSAOP3 was feasible and identified areas of patient need. Results highlight the prevalence of psychological distress and cognitive impairment. Geriatric screening offers an opportunity for prehabilitation prior to trial and support during trial participation to optimise safety and improve trial access. | |
dc.format | Print | |
dc.format.extent | e2083 - | |
dc.language | eng | |
dc.language.iso | eng | en_US |
dc.publisher | WILEY | en_US |
dc.relation.ispartof | Cancer Reports | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en_US |
dc.subject | clinical trial | |
dc.subject | geriatric assessment | |
dc.subject | phase I | |
dc.subject | Humans | |
dc.subject | Aged | |
dc.subject | Female | |
dc.subject | Male | |
dc.subject | Geriatric Assessment | |
dc.subject | Aged, 80 and over | |
dc.subject | Neoplasms | |
dc.subject | Clinical Trials, Phase I as Topic | |
dc.subject | Surveys and Questionnaires | |
dc.subject | Cognitive Dysfunction | |
dc.subject | Feasibility Studies | |
dc.subject | Mass Screening | |
dc.title | A single-centre study evaluating a geriatric screening tool in oncology phase I trial patients. | en_US |
dc.type | Journal Article | |
dcterms.dateAccepted | 2024-04-08 | |
dc.date.updated | 2024-08-30T10:28:44Z | |
rioxxterms.version | VoR | en_US |
rioxxterms.versionofrecord | 10.1002/cnr2.2083 | en_US |
rioxxterms.licenseref.startdate | 2024-06-01 | |
rioxxterms.type | Journal Article/Review | en_US |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/38923791 | |
pubs.issue | 6 | |
pubs.organisational-group | ICR | |
pubs.organisational-group | ICR/Primary Group | |
pubs.organisational-group | ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | ICR/Primary Group/ICR Divisions/Breast Cancer Research | |
pubs.organisational-group | ICR/Primary Group/ICR Divisions/Clinical Studies | |
pubs.organisational-group | ICR/Primary Group/ICR Divisions/Clinical Studies/Clinical Pharmacology – Adaptive Therapy | |
pubs.organisational-group | ICR/Primary Group/ICR Divisions/Clinical Studies/Prostate Cancer Targeted Therapy Group | |
pubs.organisational-group | ICR/Primary Group/ICR Divisions/Clinical Studies/The Adult Drug Development Unit at the ICR and the RM | |
pubs.organisational-group | ICR/Primary Group/ICR Divisions/Breast Cancer Research/Breast Cancer Clinical Research | |
pubs.organisational-group | ICR/Primary Group/ICR Divisions/Clinical Studies/Translational Therapeutics | |
pubs.organisational-group | ICR/Primary Group/ICR Divisions/Clinical Studies/Early Phase Drug Development | |
pubs.publication-status | Published | |
pubs.publisher-url | http://dx.doi.org/10.1002/cnr2.2083 | |
pubs.volume | 7 | |
icr.researchteam | Clinical Pharmacology | en_US |
icr.researchteam | PrCa Targeted Therapy | en_US |
icr.researchteam | Translational Therapeutic | en_US |
icr.researchteam | Early Phase Drug Develop | en_US |
icr.researchteam | Breast Cancer Clin Res | en_US |
icr.researchteam | Adult DDU ICR & RM | en_US |
dc.contributor.icrauthor | Banerji, Udai | |
dc.contributor.icrauthor | De Bono, Johann | |
dc.contributor.icrauthor | Sharp, Adam | |
dc.contributor.icrauthor | Battisti, Nicolo | |
dc.contributor.icrauthor | Minchom, Anna | |
icr.provenance | Deposited by Mr Arek Surman on 2024-08-30. Deposit type is initial. No. of files: 1. Files: A single-centre study evaluating a geriatric screening tool in oncology phase I trial patients.pdf | |