Now showing items 1-5 of 5

    • Autophagy inhibition-mediated epithelial-mesenchymal transition augments local myofibroblast differentiation in pulmonary fibrosis. 

      Hill, C; Li, J; Liu, D; Conforti, F; Brereton, CJ; Yao, L; Zhou, Y; Alzetani, A; Chee, SJ; Marshall, BG; Fletcher, SV; Hancock, D; Ottensmeier, CH; Steele, AJ; Downward, J; Richeldi, L; Lu, X; Davies, DE; Jones, MG; Wang, Y (2019-08-07)
      Idiopathic pulmonary fibrosis (IPF), the prototypic progressive fibrotic interstitial lung disease, is thought to be a consequence of repetitive micro-injuries to an ageing, susceptible alveolar epithelium. Ageing is a ...
    • The coordinated action of VCP/p97 and GCN2 regulates cancer cell metabolism and proteostasis during nutrient limitation. 

      Parzych, K; Saavedra-García, P; Valbuena, GN; Al-Sadah, HA; Robinson, ME; Penfold, L; Kuzeva, DM; Ruiz-Tellez, A; Loaiza, S; Holzmann, V; Caputo, V; Johnson, DC; Kaiser, MF; Karadimitris, A; Lam, EW-F; Chevet, E; Feldhahn, N; Keun, HC; Auner, HW (2019-04)
      VCP/p97 regulates numerous cellular functions by mediating protein degradation through its segregase activity. Its key role in governing protein homoeostasis has made VCP/p97 an appealing anticancer drug target. Here, we ...
    • DNA repair deficiency sensitizes lung cancer cells to NAD+ biosynthesis blockade. 

      Touat, M; Sourisseau, T; Dorvault, N; Chabanon, RM; Garrido, M; Morel, D; Krastev, DB; Bigot, L; Adam, J; Frankum, JR; Durand, S; Pontoizeau, C; Souquère, S; Kuo, M-S; Sauvaigo, S; Mardakheh, F; Sarasin, A; Olaussen, KA; Friboulet, L; Bouillaud, F; Pierron, G; Ashworth, A; Lombès, A; Lord, CJ; Soria, J-C; Postel-Vinay, S (2018-04)
      Synthetic lethality is an efficient mechanism-based approach to selectively target DNA repair defects. Excision repair cross-complementation group 1 (ERCC1) deficiency is frequently found in non-small-cell lung cancer ...
    • PARP inhibition enhances tumor cell-intrinsic immunity in ERCC1-deficient non-small cell lung cancer. 

      Chabanon, RM; Muirhead, G; Krastev, DB; Adam, J; Morel, D; Garrido, M; Lamb, A; Hénon, C; Dorvault, N; Rouanne, M; Marlow, R; Bajrami, I; Cardeñosa, ML; Konde, A; Besse, B; Ashworth, A; Pettitt, SJ; Haider, S; Marabelle, A; Tutt, AN; Soria, J-C; Lord, CJ; Postel-Vinay, S (2019-03)
      The cyclic GMP-AMP synthase/stimulator of IFN genes (cGAS/STING) pathway detects cytosolic DNA to activate innate immune responses. Poly(ADP-ribose) polymerase inhibitors (PARPi) selectively target cancer cells with DNA ...
    • Tumour-suppression function of KLF12 through regulation of anoikis. 

      Godin-Heymann, N; Brabetz, S; Murillo, MM; Saponaro, M; Santos, CR; Lobley, A; East, P; Chakravarty, P; Matthews, N; Kelly, G; Jordan, S; Castellano, E; Downward, J (2016-06)
      Suppression of detachment-induced cell death, known as anoikis, is an essential step for cancer metastasis to occur. We report here that expression of KLF12, a member of the Kruppel-like family of transcription factors, ...