Now showing items 1-3 of 3

    • Comprehensive genetic analysis of seven large families with mismatch repair proficient colorectal cancer. 

      Middeldorp, A; Jagmohan-Changur, SC; van der Klift, HM; van Puijenbroek, M; Houwing-Duistermaat, JJ; Webb, E; Houlston, R; Tops, C; Vasen, HFA; Devilee, P; Morreau, H; van Wezel, T; Wijnen, J (2010-06)
      Approximately 40% of colorectal cancer (CRC) families with a diagnosis of hereditary nonpolyposis CRC on the basis of clinical criteria are not a consequence of mismatch repair (MMR) deficiency. Such families provide ...
    • The evolutionary landscape of colorectal tumorigenesis. 

      Cross, W; Kovac, M; Mustonen, V; Temko, D; Davis, H; Baker, A-M; Biswas, S; Arnold, R; Chegwidden, L; Gatenbee, C; Anderson, AR; Koelzer, VH; Martinez, P; Jiang, X; Domingo, E; Woodcock, DJ; Feng, Y; Kovacova, M; Maughan, T; S:CORT Consortium; Jansen, M; Rodriguez-Justo, M; Ashraf, S; Guy, R; Cunningham, C; East, JE; Wedge, DC; Wang, LM; Palles, C; Heinimann, K; Sottoriva, A; Leedham, SJ; Graham, TA; Tomlinson, IPM (2018-10)
      The evolutionary events that cause colorectal adenomas (benign) to progress to carcinomas (malignant) remain largely undetermined. Using multi-region genome and exome sequencing of 24 benign and malignant colorectal tumours, ...
    • Many private mutations originate from the first few divisions of a human colorectal adenoma. 

      Kang, H; Salomon, MP; Sottoriva, A; Zhao, J; Toy, M; Press, MF; Curtis, C; Marjoram, P; Siegmund, K; Shibata, D (2015-11)
      Intratumoural mutational heterogeneity (ITH) or the presence of different private mutations in different parts of the same tumour is commonly observed in human tumours. The mechanisms generating such ITH are uncertain. ...