dc.contributor.author | Sharma, RA | |
dc.contributor.author | Plummer, R | |
dc.contributor.author | Stock, JK | |
dc.contributor.author | Greenhalgh, TA | |
dc.contributor.author | Ataman, O | |
dc.contributor.author | Kelly, S | |
dc.contributor.author | Clay, R | |
dc.contributor.author | Adams, RA | |
dc.contributor.author | Baird, RD | |
dc.contributor.author | Billingham, L | |
dc.contributor.author | Brown, SR | |
dc.contributor.author | Buckland, S | |
dc.contributor.author | Bulbeck, H | |
dc.contributor.author | Chalmers, AJ | |
dc.contributor.author | Clack, G | |
dc.contributor.author | Cranston, AN | |
dc.contributor.author | Damstrup, L | |
dc.contributor.author | Ferraldeschi, R | |
dc.contributor.author | Forster, MD | |
dc.contributor.author | Golec, J | |
dc.contributor.author | Hagan, RM | |
dc.contributor.author | Hall, E | |
dc.contributor.author | Hanauske, A-R | |
dc.contributor.author | Harrington, KJ | |
dc.contributor.author | Haswell, T | |
dc.contributor.author | Hawkins, MA | |
dc.contributor.author | Illidge, T | |
dc.contributor.author | Jones, H | |
dc.contributor.author | Kennedy, AS | |
dc.contributor.author | McDonald, F | |
dc.contributor.author | Melcher, T | |
dc.contributor.author | O'Connor, JPB | |
dc.contributor.author | Pollard, JR | |
dc.contributor.author | Saunders, MP | |
dc.contributor.author | Sebag-Montefiore, D | |
dc.contributor.author | Smitt, M | |
dc.contributor.author | Staffurth, J | |
dc.contributor.author | Stratford, IJ | |
dc.contributor.author | Wedge, SR | |
dc.contributor.author | NCRI CTRad Academia-Pharma Joint Working Group, | |
dc.date.accessioned | 2016-08-26T15:13:03Z | |
dc.date.issued | 2016-10-01 | |
dc.identifier.citation | Nature reviews. Clinical oncology, 2016, 13 (10), pp. 627 - 642 | |
dc.identifier.issn | 1759-4774 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/74 | |
dc.identifier.eissn | 1759-4782 | |
dc.identifier.doi | 10.1038/nrclinonc.2016.79 | |
dc.description.abstract | In countries with the best cancer outcomes, approximately 60% of patients receive radiotherapy as part of their treatment, which is one of the most cost-effective cancer treatments. Notably, around 40% of cancer cures include the use of radiotherapy, either as a single modality or combined with other treatments. Radiotherapy can provide enormous benefit to patients with cancer. In the past decade, significant technical advances, such as image-guided radiotherapy, intensity-modulated radiotherapy, stereotactic radiotherapy, and proton therapy enable higher doses of radiotherapy to be delivered to the tumour with significantly lower doses to normal surrounding tissues. However, apart from the combination of traditional cytotoxic chemotherapy with radiotherapy, little progress has been made in identifying and defining optimal targeted therapy and radiotherapy combinations to improve the efficacy of cancer treatment. The National Cancer Research Institute Clinical and Translational Radiotherapy Research Working Group (CTRad) formed a Joint Working Group with representatives from academia, industry, patient groups and regulatory bodies to address this lack of progress and to publish recommendations for future clinical research. Herein, we highlight the Working Group's consensus recommendations to increase the number of novel drugs being successfully registered in combination with radiotherapy to improve clinical outcomes for patients with cancer. | |
dc.format | Print-Electronic | |
dc.format.extent | 627 - 642 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | NATURE PUBLISHING GROUP | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | |
dc.subject | NCRI CTRad Academia-Pharma Joint Working Group | |
dc.subject | Humans | |
dc.subject | Neoplasms | |
dc.subject | Antineoplastic Combined Chemotherapy Protocols | |
dc.subject | Treatment Outcome | |
dc.subject | Combined Modality Therapy | |
dc.subject | Drug Approval | |
dc.subject | Radiation Dosage | |
dc.subject | Cell Hypoxia | |
dc.subject | Radiation Tolerance | |
dc.subject | Patient Participation | |
dc.subject | Quality of Health Care | |
dc.subject | Quality Assurance, Health Care | |
dc.subject | Clinical Trials as Topic | |
dc.subject | Patient Education as Topic | |
dc.title | Clinical development of new drug-radiotherapy combinations. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2016-05-15 | |
rioxxterms.versionofrecord | 10.1038/nrclinonc.2016.79 | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by/4.0 | |
rioxxterms.licenseref.startdate | 2016-10 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | Nature reviews. Clinical oncology | |
pubs.issue | 10 | |
pubs.notes | No embargo | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Biology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Biology/Targeted Therapy | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/ICR-CTSU Urology and Head and Neck Trials Team | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Quantitative Biomedical Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Targeted Therapy | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Biology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Biology/Targeted Therapy | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/ICR-CTSU Urology and Head and Neck Trials Team | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Quantitative Biomedical Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Targeted Therapy | |
pubs.publication-status | Published | |
pubs.volume | 13 | |
pubs.embargo.terms | No embargo | |
icr.researchteam | ICR-CTSU Urology and Head and Neck Trials Team | |
icr.researchteam | Quantitative Biomedical Imaging | |
icr.researchteam | Targeted Therapy | |
dc.contributor.icrauthor | Hall, Emma | |
dc.contributor.icrauthor | Harrington, Kevin | |
dc.contributor.icrauthor | O'Connor, James Patrick | |