Browsing Radiotherapy and Imaging by author "Delgado-Goni, Teresa"
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The BRAF Inhibitor Vemurafenib Activates Mitochondrial Metabolism and Inhibits Hyperpolarized Pyruvate-Lactate Exchange in BRAF-Mutant Human Melanoma Cells.
Delgado-Goni, T; Miniotis, MF; Wantuch, S; Parkes, HG; Marais, R; Workman, P; Leach, MO; Beloueche-Babari, M (2016-12)Understanding the impact of BRAF signaling inhibition in human melanoma on key disease mechanisms is important for developing biomarkers of therapeutic response and combination strategies to improve long-term disease ... -
Detecting human melanoma cell re-differentiation following BRAF or heat shock protein 90 inhibition using photoacoustic and magnetic resonance imaging.
Shah, A; Delgado-Goni, T; Casals Galobart, T; Wantuch, S; Jamin, Y; Leach, MO; Robinson, SP; Bamber, J; Beloueche-Babari, M (2017-08-15)Targeted therapies specific to the BRAF-MEK-ERK signaling pathway have shown great promise in the treatment of malignant melanoma in the last few years, with these drugs now commonly used in clinic. Melanoma cells treated ...