Now showing items 21-40 of 435

    • Fine-Scale Mapping at 9p22.2 Identifies Candidate Causal Variants That Modify Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers. 

      Vigorito, E; Kuchenbaecker, KB; Beesley, J; Adlard, J; Agnarsson, BA; Andrulis, IL; Arun, BK; Barjhoux, L; Belotti, M; Benitez, J; Berger, A; Bojesen, A; Bonanni, B; Brewer, C; Caldes, T; Caligo, MA; Campbell, I; Chan, SB; Claes, KB; Cohn, DE; Cook, J; Daly, MB; Damiola, F; Davidson, R; Pauw, A; Delnatte, C; Diez, O; Domchek, SM; Dumont, M; Durda, K; Dworniczak, B; Easton, DF; Eccles, D; Edwinsdotter Ardnor, C; Eeles, R; Ejlertsen, B; Ellis, S; Evans, DG; Feliubadalo, L; Fostira, F; Foulkes, WD; Friedman, E; Frost, D; Gaddam, P; Ganz, PA; Garber, J; Garcia-Barberan, V; Gauthier-Villars, M; Gehrig, A; Gerdes, AM; Giraud, S; Godwin, AK; Goldgar, DE; Hake, CR; Hansen, TV; Healey, S; Hodgson, S; Hogervorst, FB; Houdayer, C; Hulick, PJ; Imyanitov, EN; Isaacs, C; Izatt, L; Izquierdo, A; Jacobs, L; Jakubowska, A; Janavicius, R; Jaworska-Bieniek, K; Jensen, UB; John, EM; Vijai, J; Karlan, BY; Kast, K; Investigators, K; Khan, S; Kwong, A; Laitman, Y; Lester, J; Lesueur, F; Liljegren, A; Lubinski, J; Mai, PL; Manoukian, S; Mazoyer, S; Meindl, A; Mensenkamp, AR; Montagna, M; Nathanson, KL; Neuhausen, SL; Nevanlinna, H; Niederacher, D; Olah, E; Olopade, OI; Ong, KR; Osorio, A; Park, SK; Paulsson-Karlsson, Y; Pedersen, IS; Peissel, B; Peterlongo, P; Pfeiler, G; Phelan, CM; Piedmonte, M; Poppe, B; Pujana, MA; Radice, P; Rennert, G; Rodriguez, GC; Rookus, MA; Ross, EA; Schmutzler, RK; Simard, J; Singer, CF; Slavin, TP; Soucy, P; Southey, M; Steinemann, D; Stoppa-Lyonnet, D; Sukiennicki, G; Sutter, C; Szabo, CI; Tea, MK; Teixeira, MR; Teo, SH; Terry, MB; Thomassen, M; Tibiletti, MG; Tihomirova, L; Tognazzo, S; van Rensburg, EJ; Varesco, L; Varon-Mateeva, R; Vratimos, A; Weitzel, JN; McGuffog, L; Kirk, J; Toland, AE; Hamann, U; Lindor, N; Ramus, SJ; Greene, MH; Couch, FJ; Offit, K; Pharoah, PD; Chenevix-Trench, G; Antoniou, AC (2016-01)
      Population-based genome wide association studies have identified a locus at 9p22.2 associated with ovarian cancer risk, which also modifies ovarian cancer risk in BRCA1 and BRCA2 mutation carriers. We conducted fine-scale ...
    • Investigation of In Vivo skin stiffness anisotropy in breast cancer related lymphoedema. 

      Coutts, LV; Miller, NR; Mortimer, PS; Bamber, JC (2016-01)
      There is a limited range of suitable measurement techniques for detecting and assessing breast cancer related lymphoedema (BCRL). This study investigated the suitability of using skin stiffness measurements, with a particular ...
    • Pubertal development and prostate cancer risk: Mendelian randomization study in a population-based cohort. 

      Bonilla, C; Lewis, SJ; Martin, RM; Donovan, JL; Hamdy, FC; Neal, DE; Eeles, R; Easton, D; Kote-Jarai, Z; Al Olama, AA; Benlloch, S; Muir, K; Giles, GG; Wiklund, F; Gronberg, H; Haiman, CA; Schleutker, J; Nordestgaard, BG; Travis, RC; Pashayan, N; Khaw, KT; Stanford, JL; Blot, WJ; Thibodeau, S; Maier, C; Kibel, AS; Cybulski, C; Cannon-Albright, L; Brenner, H; Park, J; Kaneva, R; Batra, J; Teixeira, MR; Pandha, H; Lathrop, M; Davey Smith, G (2016-01)
      Epidemiological studies have observed a positive association between an earlier age at sexual development and prostate cancer, but markers of sexual maturation in boys are imprecise and observational estimates are likely ...
    • Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation. 

      Gusev, A; Shi, H; Kichaev, G; Pomerantz, M; Li, F; Long, HW; Ingles, SA; Kittles, RA; Strom, SS; Rybicki, BA; Nemesure, B; Isaacs, WB; Zheng, W; Pettaway, CA; Yeboah, ED; Tettey, Y; Biritwum, RB; Adjei, AA; Tay, E; Truelove, A; Niwa, S; Chokkalingam, AP; John, EM; Murphy, AB; Signorello, LB; Carpten, J; Leske, MC; Wu, SY; Hennis, AJ; Neslund-Dudas, C; Hsing, AW; Chu, L; Goodman, PJ; Klein, EA; Witte, JS; Casey, G; Kaggwa, S; Cook, MB; Stram, DO; Blot, WJ; Eeles, RA; Easton, D; Kote-Jarai, Z; Al Olama, AA; Benlloch, S; Muir, K; Giles, GG; Southey, MC; Fitzgerald, LM; Gronberg, H; Wiklund, F; Aly, M; Henderson, BE; Schleutker, J; Wahlfors, T; Tammela, TL; Nordestgaard, BG; Key, TJ; Travis, RC; Neal, DE; Donovan, JL; Hamdy, FC; Pharoah, P; Pashayan, N; Khaw, KT; Stanford, JL; Thibodeau, SN; McDonnell, SK; Schaid, DJ; Maier, C; Vogel, W; Luedeke, M; Herkommer, K; Kibel, AS; Cybulski, C; Wokolorczyk, D; Kluzniak, W; Cannon-Albright, L; Teerlink, C; Brenner, H; Dieffenbach, AK; Arndt, V; Park, JY; Sellers, TA; Lin, HY; Slavov, C; Kaneva, R; Mitev, V; Batra, J; Spurdle, A; Clements, JA; Teixeira, MR; Pandha, H; Michael, A; Paulo, P; Maia, S; Kierzek, A; Conti, DV; Albanes, D; Berg, C; Berndt, SI; Campa, D; Crawford, ED; Diver, WR; Gapstur, SM; Gaziano, JM; Giovannucci, E; Hoover, R; Hunter, DJ; Johansson, M; Kraft, P; Le Marchand, L; Lindström, S; Navarro, C; Overvad, K; Riboli, E; Siddiq, A; Stevens, VL; Trichopoulos, D; Vineis, P; Yeager, M; Trynka, G; Raychaudhuri, S; Schumacher, FR; Price, AL; Freedman, ML; Haiman, CA; Pasaniuc, B (2016-01)
      Although genome-wide association studies have identified over 100 risk loci that explain ∼33% of familial risk for prostate cancer (PrCa), their functional effects on risk remain largely unknown. Here we use genotype data ...
    • Classification of fibroglandular tissue distribution in the breast based on radiotherapy planning CT. 

      Juneja, P; Evans, P; Windridge, D; Harris, E (2016-01-14)
      Accurate segmentation of breast tissues is required for a number of applications such as model based deformable registration in breast radiotherapy. The accuracy of breast tissue segmentation is affected by the spatial ...
    • Assessment of MLC tracking performance during hypofractionated prostate radiotherapy using real-time dose reconstruction. 

      Fast, MF; Kamerling, CP; Ziegenhein, P; Menten, MJ; Bedford, JL; Nill, S; Oelfke, U (2016-02)
      By adapting to the actual patient anatomy during treatment, tracked multi-leaf collimator (MLC) treatment deliveries offer an opportunity for margin reduction and healthy tissue sparing. This is assumed to be especially ...
    • Prostate-specific Antigen Decline After 4 Weeks of Treatment with Abiraterone Acetate and Overall Survival in Patients with Metastatic Castration-resistant Prostate Cancer. 

      Rescigno, P; Lorente, D; Bianchini, D; Ferraldeschi, R; Kolinsky, MP; Sideris, S; Zafeiriou, Z; Sumanasuriya, S; Smith, AD; Mehra, N; Jayaram, A; Perez-Lopez, R; Mateo, J; Parker, C; Dearnaley, DP; Tunariu, N; Reid, A; Attard, G; de Bono, JS (2016-03-07)
      The availability of multiple new treatments for metastatic castration-resistant prostate cancer (mCRPC) mandates earlier treatment switches in the absence of a response. A decline in prostate-specific antigen (PSA) is ...
    • Repeatability of derived parameters from histograms following non-Gaussian diffusion modelling of diffusion-weighted imaging in a paediatric oncological cohort. 

      Jerome, NP; Miyazaki, K; Collins, DJ; Orton, MR; d'Arcy, JA; Wallace, T; Moreno, L; Pearson, AD; Marshall, LV; Carceller, F; Leach, MO; Zacharoulis, S; Koh, DM (2016-03-22)
      To examine repeatability of parameters derived from non-Gaussian diffusion models in data acquired in children with solid tumours.Paediatric patients (<16 years, n = 17) were scanned twice, 24 h apart, using DWI (6 b-values, ...
    • Assessment of fully-automated atlas-based segmentation of novel oral mucosal surface organ-at-risk. 

      Dean, JA; Welsh, LC; McQuaid, D; Wong, KH; Aleksic, A; Dunne, E; Islam, MR; Patel, A; Patel, P; Petkar, I; Phillips, I; Sham, J; Newbold, KL; Bhide, SA; Harrington, KJ; Gulliford, SL; Nutting, CM (2016-04)
      Current oral mucositis normal tissue complication probability models, based on the dose distribution to the oral cavity volume, have suboptimal predictive power. Improving the delineation of the oral mucosa is likely to ...
    • Comparison of optimised endovaginal vs external array coil T2-weighted and diffusion-weighted imaging techniques for detecting suspected early stage (IA/IB1) uterine cervical cancer. 

      Downey, K; Attygalle, AD; Morgan, VA; Giles, SL; MacDonald, A; Davis, M; Ind, TE; Shepherd, JH; deSouza, NM (2016-04)
      To compare sensitivity and specificity of endovaginal versus external-array coil T2-W and T2-W + DWI for detecting and staging small cervical tumours.Optimised endovaginal and external array coil MRI at 3.0-T was done ...
    • 18F-FDG PET/CT in Detecting Metastatic Infection in Children. 

      Kouijzer, IJ; Blokhuis, GJ; Draaisma, JM; Oyen, WJ; de Geus-Oei, LF; Bleeker-Rovers, CP (2016-04)
      Metastatic infection is a severe complication of bacteremia with high morbidity and mortality. The aim of this study was to investigate the diagnostic value of 18F-FDG PET combined with CT (FDG PET/CT) in children suspected ...
    • Prospective Study Delivering Simultaneous Integrated High-dose Tumor Boost (≤70 Gy) With Image Guided Adaptive Radiation Therapy for Radical Treatment of Localized Muscle-Invasive Bladder Cancer. 

      Hafeez, S; Warren-Oseni, K; McNair, HA; Hansen, VN; Jones, K; Tan, M; Khan, A; Harris, V; McDonald, F; Lalondrelle, S; Mohammed, K; Thomas, K; Thompson, A; Kumar, P; Dearnaley, D; Horwich, A; Huddart, R (2016-04)
      Image guided adaptive radiation therapy offers individualized solutions to improve target coverage and reduce normal tissue irradiation, allowing the opportunity to increase the radiation tumor dose and spare normal bladder ...
    • Does breast composition influence late adverse effects in breast radiotherapy? 

      Juneja, P; Bonora, M; Haviland, JS; Harris, E; Evans, P; Somaiah, N (2016-04)
      Large breast size is associated with increased risk of late adverse effects after surgery and radiotherapy for early breast cancer. It is hypothesised that effects of radiotherapy on adipose tissue are responsible for some ...
    • Gene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array. 

      Saunders, EJ; Dadaev, T; Leongamornlert, DA; Al Olama, AA; Benlloch, S; Giles, GG; Wiklund, F; Gronberg, H; Haiman, CA; Schleutker, J; Nordestgaard, BG; Travis, RC; Neal, D; Pasayan, N; Khaw, KT; Stanford, JL; Blot, WJ; Thibodeau, SN; Maier, C; Kibel, AS; Cybulski, C; Cannon-Albright, L; Brenner, H; Park, JY; Kaneva, R; Batra, J; Teixeira, MR; Pandha, H; Govindasami, K; Muir, K; Easton, DF; Eeles, RA; Kote-Jarai, Z (2016-04)
      Germline mutations within DNA-repair genes are implicated in susceptibility to multiple forms of cancer. For prostate cancer (PrCa), rare mutations in BRCA2 and BRCA1 give rise to moderately elevated risk, whereas two of ...
    • Review of ultrasound image guidance in external beam radiotherapy part II: intra-fraction motion management and novel applications. 

      O'Shea, T; Bamber, J; Fontanarosa, D; van der Meer, S; Verhaegen, F; Harris, E (2016-04)
      Imaging has become an essential tool in modern radiotherapy (RT), being used to plan dose delivery prior to treatment and verify target position before and during treatment. Ultrasound (US) imaging is cost-effective in ...
    • A dosimetric comparison of real-time adaptive and non-adaptive radiotherapy: A multi-institutional study encompassing robotic, gimbaled, multileaf collimator and couch tracking. 

      Colvill, E; Booth, J; Nill, S; Fast, M; Bedford, J; Oelfke, U; Nakamura, M; Poulsen, P; Worm, E; Hansen, R; Ravkilde, T; Scherman Rydhög, J; Pommer, T; Munck Af Rosenschold, P; Lang, S; Guckenberger, M; Groh, C; Herrmann, C; Verellen, D; Poels, K; Wang, L; Hadsell, M; Sothmann, T; Blanck, O; Keall, P (2016-04)
      A study of real-time adaptive radiotherapy systems was performed to test the hypothesis that, across delivery systems and institutions, the dosimetric accuracy is improved with adaptive treatments over non-adaptive ...
    • Oncolytic vaccinia virus as a vector for therapeutic sodium iodide symporter gene therapy in prostate cancer. 

      Mansfield, DC; Kyula, JN; Rosenfelder, N; Chao-Chu, J; Kramer-Marek, G; Khan, AA; Roulstone, V; McLaughlin, M; Melcher, AA; Vile, RG; Pandha, HS; Khoo, V; Harrington, KJ (2016-04)
      Oncolytic strains of vaccinia virus are currently in clinical development with clear evidence of safety and promising signs of efficacy. Addition of therapeutic genes to the viral genome may increase the therapeutic efficacy ...
    • A computerized volumetric segmentation method applicable to multi-centre MRI data to support computer-aided breast tissue analysis, density assessment and lesion localization. 

      Ertas, G; Doran, SJ; Leach, MO (2016-04-22)
      Density assessment and lesion localization in breast MRI require accurate segmentation of breast tissues. A fast, computerized algorithm for volumetric breast segmentation, suitable for multi-centre data, has been developed, ...
    • Laryngeal cancer: United Kingdom National Multidisciplinary guidelines. 

      Jones, TM; De, M; Foran, B; Harrington, K; Mortimore, S (2016-05)
      This is the official guideline endorsed by the specialty associations involved in the care of head and neck cancer patients in the UK. Significantly new data have been published on laryngeal cancer management since the ...
    • Individualized 131I-mIBG therapy in the management of refractory and relapsed neuroblastoma. 

      George, SL; Falzone, N; Chittenden, S; Kirk, SJ; Lancaster, D; Vaidya, SJ; Mandeville, H; Saran, F; Pearson, AD; Du, Y; Meller, ST; Denis-Bacelar, AM; Flux, GD (2016-05)
      Iodine-131-labelled meta-iodobenzylguanidine (I-mIBG) therapy is an established treatment modality for relapsed/refractory neuroblastoma, most frequently administered according to fixed or weight-based criteria. We evaluate ...