Now showing items 379-398 of 1026

    • Genome-wide linkage analysis of 1,233 prostate cancer pedigrees from the International Consortium for Prostate Cancer Genetics using novel sumLINK and sumLOD analyses. 

      Christensen, GB; Baffoe-Bonnie, AB; George, A; Powell, I; Bailey-Wilson, JE; Carpten, JD; Giles, GG; Hopper, JL; Severi, G; English, DR; Foulkes, WD; Maehle, L; Moller, P; Eeles, R; Easton, D; Badzioch, MD; Whittemore, AS; Oakley-Girvan, I; Hsieh, C-L; Dimitrov, L; Xu, J; Stanford, JL; Johanneson, B; Deutsch, K; McIntosh, L; Ostrander, EA; Wiley, KE; Isaacs, SD; Walsh, PC; Isaacs, WB; Thibodeau, SN; McDonnell, SK; Hebbring, S; Schaid, DJ; Lange, EM; Cooney, KA; Tammela, TLJ; Schleutker, J; Paiss, T; Maier, C; Grönberg, H; Wiklund, F; Emanuelsson, M; Farnham, JM; Cannon-Albright, LA; Camp, NJ; International Consortium for Prostate Cancer Genetics (2010-05)
      <h4>Background</h4>Prostate cancer (PC) is generally believed to have a strong inherited component, but the search for susceptibility genes has been hindered by the effects of genetic heterogeneity. The recently developed ...
    • Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types. 

      Kar, SP; Beesley, J; Amin Al Olama, A; Michailidou, K; Tyrer, J; Kote-Jarai, Z; Lawrenson, K; Lindstrom, S; Ramus, SJ; Thompson, DJ; ABCTB Investigators; Kibel, AS; Dansonka-Mieszkowska, A; Michael, A; Dieffenbach, AK; Gentry-Maharaj, A; Whittemore, AS; Wolk, A; Monteiro, A; Peixoto, A; Kierzek, A; Cox, A; Rudolph, A; Gonzalez-Neira, A; Wu, AH; Lindblom, A; Swerdlow, A; AOCS Study Group & Australian Cancer Study (Ovarian Cancer); APCB BioResource; Ziogas, A; Ekici, AB; Burwinkel, B; Karlan, BY; Nordestgaard, BG; Blomqvist, C; Phelan, C; McLean, C; Pearce, CL; Vachon, C; Cybulski, C; Slavov, C; Stegmaier, C; Maier, C; Ambrosone, CB; Høgdall, CK; Teerlink, CC; Kang, D; Tessier, DC; Schaid, DJ; Stram, DO; Cramer, DW; Neal, DE; Eccles, D; Flesch-Janys, D; Edwards, DRV; Wokozorczyk, D; Levine, DA; Yannoukakos, D; Sawyer, EJ; Bandera, EV; Poole, EM; Goode, EL; Khusnutdinova, E; Høgdall, E; Song, F; Bruinsma, F; Heitz, F; Modugno, F; Hamdy, FC; Wiklund, F; Giles, GG; Olsson, H; Wildiers, H; Ulmer, H-U; Pandha, H; Risch, HA; Darabi, H; Salvesen, HB; Nevanlinna, H; Gronberg, H; Brenner, H; Brauch, H; Anton-Culver, H; Song, H; Lim, H-Y; McNeish, I; Campbell, I; Vergote, I; Gronwald, J; Lubiński, J; Stanford, JL; Benítez, J; Doherty, JA; Permuth, JB; Chang-Claude, J; Donovan, JL; Dennis, J; Schildkraut, JM; Schleutker, J; Hopper, JL; Kupryjanczyk, J; Park, JY; Figueroa, J; Clements, JA; Knight, JA; Peto, J; Cunningham, JM; Pow-Sang, J; Batra, J; Czene, K; Lu, KH; Herkommer, K; Khaw, K-T; kConFab Investigators; Matsuo, K; Muir, K; Offitt, K; Chen, K; Moysich, KB; Aittomäki, K; Odunsi, K; Kiemeney, LA; Massuger, LFAG; Fitzgerald, LM; Cook, LS; Cannon-Albright, L; Hooning, MJ; Pike, MC; Bolla, MK; Luedeke, M; Teixeira, MR; Goodman, MT; Schmidt, MK; Riggan, M; Aly, M; Rossing, MA; Beckmann, MW; Moisse, M; Sanderson, M; Southey, MC; Jones, M; Lush, M; Hildebrandt, MAT; Hou, M-F; Schoemaker, MJ; Garcia-Closas, M; Bogdanova, N; Rahman, N; NBCS Investigators; Le, ND; Orr, N; Wentzensen, N; Pashayan, N; Peterlongo, P; Guénel, P; Brennan, P; Paulo, P; Webb, PM; Broberg, P; Fasching, PA; Devilee, P; Wang, Q; Cai, Q; Li, Q; Kaneva, R; Butzow, R; Kopperud, RK; Schmutzler, RK; Stephenson, RA; MacInnis, RJ; Hoover, RN; Winqvist, R; Ness, R; Milne, RL; Travis, RC; Benlloch, S; Olson, SH; McDonnell, SK; Tworoger, SS; Maia, S; Berndt, S; Lee, SC; Teo, S-H; Thibodeau, SN; Bojesen, SE; Gapstur, SM; Kjær, SK; Pejovic, T; Tammela, TLJ; GENICA Network; PRACTICAL consortium; Dörk, T; Brüning, T; Wahlfors, T; Key, TJ; Edwards, TL; Menon, U; Hamann, U; Mitev, V; Kosma, V-M; Setiawan, VW; Kristensen, V; Arndt, V; Vogel, W; Zheng, W; Sieh, W; Blot, WJ; Kluzniak, W; Shu, X-O; Gao, Y-T; Schumacher, F; Freedman, ML; Berchuck, A; Dunning, AM; Simard, J; Haiman, CA; Spurdle, A; Sellers, TA; Hunter, DJ; Henderson, BE; Kraft, P; Chanock, SJ; Couch, FJ; Hall, P; Gayther, SA; Easton, DF; Chenevix-Trench, G; Eeles, R; Pharoah, PDP; Lambrechts, D (2016-09)
      <h4>Unlabelled</h4>Breast, ovarian, and prostate cancers are hormone-related and may have a shared genetic basis, but this has not been investigated systematically by genome-wide association (GWA) studies. Meta-analyses ...
    • A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease. 

      Scott, RA; Freitag, DF; Li, L; Chu, AY; Surendran, P; Young, R; Grarup, N; Stancáková, A; Chen, Y; Varga, TV; Yaghootkar, H; Luan, J; Zhao, JH; Willems, SM; Wessel, J; Wang, S; Maruthur, N; Michailidou, K; Pirie, A; van der Lee, SJ; Gillson, C; Al Olama, AA; Amouyel, P; Arriola, L; Arveiler, D; Aviles-Olmos, I; Balkau, B; Barricarte, A; Barroso, I; Garcia, SB; Bis, JC; Blankenberg, S; Boehnke, M; Boeing, H; Boerwinkle, E; Borecki, IB; Bork-Jensen, J; Bowden, S; Caldas, C; Caslake, M; CVD50 consortium; Cupples, LA; Cruchaga, C; Czajkowski, J; den Hoed, M; Dunn, JA; Earl, HM; Ehret, GB; Ferrannini, E; Ferrieres, J; Foltynie, T; Ford, I; Forouhi, NG; Gianfagna, F; Gonzalez, C; Grioni, S; Hiller, L; Jansson, J-H; Jørgensen, ME; Jukema, JW; Kaaks, R; Kee, F; Kerrison, ND; Key, TJ; Kontto, J; Kote-Jarai, Z; Kraja, AT; Kuulasmaa, K; Kuusisto, J; Linneberg, A; Liu, C; Marenne, G; Mohlke, KL; Morris, AP; Muir, K; Müller-Nurasyid, M; Munroe, PB; Navarro, C; Nielsen, SF; Nilsson, PM; Nordestgaard, BG; Packard, CJ; Palli, D; Panico, S; Peloso, GM; Perola, M; Peters, A; Poole, CJ; Quirós, JR; Rolandsson, O; Sacerdote, C; Salomaa, V; Sánchez, M-J; Sattar, N; Sharp, SJ; Sims, R; Slimani, N; Smith, JA; Thompson, DJ; Trompet, S; Tumino, R; van der A, DL; van der Schouw, YT; Virtamo, J; Walker, M; Walter, K; GERAD_EC Consortium; Neurology Working Group of the Cohorts for Heart; Aging Research in Genomic Epidemiology (CHARGE); Alzheimer’s Disease Genetics Consortium; Pancreatic Cancer Cohort Consortium; European Prospective Investigation into Cancer and Nutrition–Cardiovascular Disease (EPIC-CVD); EPIC-InterAct; Abraham, JE; Amundadottir, LT; Aponte, JL; Butterworth, AS; Dupuis, J; Easton, DF; Eeles, RA; Erdmann, J; Franks, PW; Frayling, TM; Hansen, T; Howson, JMM; Jørgensen, T; Kooner, J; Laakso, M; Langenberg, C; McCarthy, MI; Pankow, JS; Pedersen, O; Riboli, E; Rotter, JI; Saleheen, D; Samani, NJ; Schunkert, H; Vollenweider, P; O'Rahilly, S; CHARGE consortium; CHD Exome+ Consortium; CARDIOGRAM Exome Consortium; Deloukas, P; Danesh, J; Goodarzi, MO; Kathiresan, S; Meigs, JB; Ehm, MG; Wareham, NJ; Waterworth, DM (2016-06)
      Regulatory authorities have indicated that new drugs to treat type 2 diabetes (T2D) should not be associated with an unacceptable increase in cardiovascular risk. Human genetics may be able to guide development of antidiabetic ...
    • Genomic gain and over expression of CCL2 correlate with vascular invasion in stage I non-seminomatous testicular germ-cell tumours. 

      Gilbert, DC; Chandler, I; Summersgill, B; McIntyre, A; Missiaglia, E; Goddard, NC; Huddart, RA; Shipley, J (2011-08)
      Testicular germ-cell tumours (TGCT) are the most frequent solid tumour to affect young Caucasian adult males and have increased in incidence over recent decades. In clinical stage I non-seminomas, (NSGCT) histological ...
    • Genomic landscape of platinum resistant and sensitive testicular cancers. 

      Loveday, C; Litchfield, K; Proszek, PZ; Cornish, AJ; Santo, F; Levy, M; Macintyre, G; Holryod, A; Broderick, P; Dudakia, D; Benton, B; Bakir, MA; Hiley, C; Grist, E; Swanton, C; Huddart, R; Powles, T; Chowdhury, S; Shipley, J; O'Connor, S; Brenton, JD; Reid, A; de Castro, DG; Houlston, RS; Turnbull, C (2020-05-04)
      While most testicular germ cell tumours (TGCTs) exhibit exquisite sensitivity to platinum chemotherapy, ~10% are platinum resistant. To gain insight into the underlying mechanisms, we undertake whole exome sequencing and ...
    • The genomic landscape of testicular germ cell tumours: from susceptibility to treatment. 

      Litchfield, K; Levy, M; Huddart, RA; Shipley, J; Turnbull, C (2016-07)
      The genomic landscape of testicular germ cell tumour (TGCT) can be summarized using four overarching hypotheses. Firstly, TGCT risk is dominated by inherited genetic factors, which determine nearly half of all disease risk ...
    • Geometric and dosimetric evaluations of atlas-based segmentation methods of MR images in the head and neck region. 

      Kieselmann, JP; Kamerling, CP; Burgos, N; Menten, MJ; Fuller, CD; Nill, S; Cardoso, MJ; Oelfke, U (2018-07-11)
      Owing to its excellent soft-tissue contrast, magnetic resonance (MR) imaging has found an increased application in radiation therapy (RT). By harnessing these properties for treatment planning, automated segmentation methods ...
    • Germline BRCA mutation and outcome in young-onset breast cancer (POSH): a prospective cohort study. 

      Copson, ER; Maishman, TC; Tapper, WJ; Cutress, RI; Greville-Heygate, S; Altman, DG; Eccles, B; Gerty, S; Durcan, LT; Jones, L; Evans, DG; Thompson, AM; Pharoah, P; Easton, DF; Dunning, AM; Hanby, A; Lakhani, S; Eeles, R; Gilbert, FJ; Hamed, H; Hodgson, S; Simmonds, P; Stanton, L; Eccles, DM (2018-02)
      <h4>Background</h4>Retrospective studies provide conflicting interpretations of the effect of inherited genetic factors on the prognosis of patients with breast cancer. The primary aim of this study was to determine the ...
    • Germline DNA Repair Gene Mutations in Young-onset Prostate Cancer Cases in the UK: Evidence for a More Extensive Genetic Panel. 

      Leongamornlert, DA; Saunders, EJ; Wakerell, S; Whitmore, I; Dadaev, T; Cieza-Borrella, C; Benafif, S; Brook, MN; Donovan, JL; Hamdy, FC; Neal, DE; Muir, K; Govindasami, K; Conti, DV; Kote-Jarai, Z; Eeles, RA (2019-09)
      <h4>Background</h4>Rare germline mutations in DNA repair genes are associated with prostate cancer (PCa) predisposition and prognosis.<h4>Objective</h4>To quantify the frequency of germline DNA repair gene mutations in UK ...
    • Germline genetic variation in prostate susceptibility does not predict outcomes in the chemoprevention trials PCPT and SELECT. 

      Ahmed, M; Goh, C; Saunders, E; Cieza-Borrella, C; PRACTICAL consortium; Kote-Jarai, Z; Schumacher, FR; Eeles, R (2020-06)
      <h4>Background</h4>The development of prostate cancer can be influenced by genetic and environmental factors. Numerous germline SNPs influence prostate cancer susceptibility. The functional pathways in which these SNPs ...
    • Germline sequencing DNA repair genes in 5,545 men with aggressive and non-aggressive prostate cancer. 

      Darst, BF; Dadaev, T; Saunders, E; Sheng, X; Wan, P; Pooler, L; Xia, LY; Chanock, S; Berndt, SI; Gapstur, SM; Stevens, V; Albanes, D; Weinstein, SJ; Gnanapragasam, V; Giles, GG; Nguyen-Dumont, T; Milne, RL; Pomerantz, M; Schmidt, JA; Mucci, L; Catalona, WJ; Hetrick, KN; Doheny, KF; MacInnis, RJ; Southey, MC; Eeles, RA; Wiklund, F; Kote-Jarai, Z; Conti, DV; Haiman, CA (2020-08-27)
      <h4>Background</h4>There is an urgent need to identify factors specifically associated with aggressive prostate cancer (PCa) risk. We investigated whether rare pathogenic, likely pathogenic, or deleterious (P/LP/D) germline ...
    • Germline variants in IL4, MGMT and AKT1 are associated with prostate cancer-specific mortality: An analysis of 12,082 prostate cancer cases. 

      FitzGerald, LM; Zhao, S; Leonardson, A; Geybels, MS; Kolb, S; Lin, DW; Wright, JL; Eeles, R; Kote-Jarai, Z; Govindasami, K; Giles, GG; Southey, MC; Schleutker, J; Tammela, TL; Sipeky, C; Penney, KL; Stampfer, MJ; Gronberg, H; Wiklund, F; Stattin, P; Hugosson, J; Karyadi, DM; Ostrander, EA; Feng, Z; Stanford, JL (2018-06)
      BACKGROUND:Prostate cancer (PCa) is a leading cause of mortality and genetic factors can influence tumour aggressiveness. Several germline variants have been associated with PCa-specific mortality (PCSM), but further ...
    • Germline variation at 8q24 and prostate cancer risk in men of European ancestry. 

      Matejcic, M; Saunders, EJ; Dadaev, T; Brook, MN; Wang, K; Sheng, X; Olama, AAA; Schumacher, FR; Ingles, SA; Govindasami, K; Benlloch, S; Berndt, SI; Albanes, D; Koutros, S; Muir, K; Stevens, VL; Gapstur, SM; Tangen, CM; Batra, J; Clements, J; Gronberg, H; Pashayan, N; Schleutker, J; Wolk, A; West, C; Mucci, L; Kraft, P; Cancel-Tassin, G; Sorensen, KD; Maehle, L; Grindedal, EM; Strom, SS; Neal, DE; Hamdy, FC; Donovan, JL; Travis, RC; Hamilton, RJ; Rosenstein, B; Lu, Y-J; Giles, GG; Kibel, AS; Vega, A; Bensen, JT; Kogevinas, M; Penney, KL; Park, JY; Stanford, JL; Cybulski, C; Nordestgaard, BG; Brenner, H; Maier, C; Kim, J; Teixeira, MR; Neuhausen, SL; De Ruyck, K; Razack, A; Newcomb, LF; Lessel, D; Kaneva, R; Usmani, N; Claessens, F; Townsend, PA; Gago-Dominguez, M; Roobol, MJ; Menegaux, F; Khaw, K-T; Cannon-Albright, LA; Pandha, H; Thibodeau, SN; Schaid, DJ; PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium; Wiklund, F; Chanock, SJ; Easton, DF; Eeles, RA; Kote-Jarai, Z; Conti, DV; Haiman, CA (2018-11-05)
      Chromosome 8q24 is a susceptibility locus for multiple cancers, including prostate cancer. Here we combine genetic data across the 8q24 susceptibility region from 71,535 prostate cancer cases and 52,935 controls of European ...
    • Global treatment patterns and outcomes among patients with recurrent and/or metastatic head and neck squamous cell carcinoma: Results of the GLANCE H&N study. 

      Grünwald, V; Chirovsky, D; Cheung, WY; Bertolini, F; Ahn, M-J; Yang, M-H; Castro, G; Berrocal, A; Sjoquist, K; Kuyas, H; Auclair, V; Guillaume, X; Joo, S; Shah, R; Harrington, K; GLANCE H&N STUDY Investigators (2020-03)
      OBJECTIVES:Given a lack of universally-accepted standard-of-care treatment for patients with recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC), study objectives were to assess treatment utilization and ...
    • Gold nanorod reshaping in vitro and in vivo using a continuous wave laser. 

      Harris-Birtill, D; Singh, M; Zhou, Y; Shah, A; Ruenraroengsak, P; Gallina, ME; Hanna, GB; Cass, AEG; Porter, AE; Bamber, J; Elson, DS (2017-01)
      Gold nanorods (GNRs) are increasingly being investigated for cancer theranostics as they possess features which lend themselves in equal measures as contrast agents and catalysts for photothermal therapy. Their optical ...
    • Growth Trajectories, Breast Size, and Breast-Tissue Composition in a British Prebirth Cohort of Young Women. 

      Denholm, R; De Stavola, B; Hipwell, JH; Doran, SJ; Busana, MC; Leach, MO; Hawkes, DJ; Dos-Santos-Silva, I (2018-06)
      Mammographic percent density, the proportion of fibroglandular tissue in the breast, is a strong risk factor for breast cancer, but its determinants in young women are unknown. We examined associations of magnetic resonance ...
    • gsSKAT: Rapid gene set analysis and multiple testing correction for rare-variant association studies using weighted linear kernels. 

      Larson, NB; McDonnell, S; Cannon Albright, L; Teerlink, C; Stanford, J; Ostrander, EA; Isaacs, WB; Xu, J; Cooney, KA; Lange, E; Schleutker, J; Carpten, JD; Powell, I; Bailey-Wilson, JE; Cussenot, O; Cancel-Tassin, G; Giles, GG; MacInnis, RJ; Maier, C; Whittemore, AS; Hsieh, C-L; Wiklund, F; Catalona, WJ; Foulkes, W; Mandal, D; Eeles, R; Kote-Jarai, Z; Ackerman, MJ; Olson, TM; Klein, CJ; Thibodeau, SN; Schaid, DJ (2017-05)
      Next-generation sequencing technologies have afforded unprecedented characterization of low-frequency and rare genetic variation. Due to low power for single-variant testing, aggregative methods are commonly used to combine ...
    • Guideline for PET/CT imaging of neuroendocrine neoplasms with <sup>68</sup>Ga-DOTA-conjugated somatostatin receptor targeting peptides and <sup>18</sup>F-DOPA. 

      Bozkurt, MF; Virgolini, I; Balogova, S; Beheshti, M; Rubello, D; Decristoforo, C; Ambrosini, V; Kjaer, A; Delgado-Bolton, R; Kunikowska, J; Oyen, WJG; Chiti, A; Giammarile, F; Sundin, A; Fanti, S (2017-08)
      <h4>Purpose & methods</h4>Neuroendocrine neoplasms are a heterogenous group of tumours, for which nuclear medicine plays an important role in the diagnostic work-up as well as in the targeted therapeutic options. This ...
    • Guidelines for Acquisition, Interpretation, and Reporting of Whole-Body MRI in Myeloma: Myeloma Response Assessment and Diagnosis System (MY-RADS). 

      Messiou, C; Hillengass, J; Delorme, S; Lecouvet, FE; Moulopoulos, LA; Collins, DJ; Blackledge, MD; Abildgaard, N; Østergaard, B; Schlemmer, H-P; Landgren, O; Asmussen, JT; Kaiser, MF; Padhani, A (2019-04)
      Acknowledging the increasingly important role of whole-body MRI for directing patient care in myeloma, a multidisciplinary, international, and expert panel of radiologists, medical physicists, and hematologists with specific ...
    • Guidelines for Cleaning Transvaginal Ultrasound Transducers Between Patients. 

      Abramowicz, JS; Evans, DH; Fowlkes, JB; Maršal, K; terHaar, G; WFUMB Safety Committee (2017-05)
      The purpose of this article is to provide guidance regarding the cleaning and disinfection of transvaginal ultrasound probes. These recommendations are also applicable to transrectal probes.