Now showing items 1-3 of 3

    • Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes. 

      Fachal, L; Aschard, H; Beesley, J; Barnes, DR; Allen, J; Kar, S; Pooley, KA; Dennis, J; Michailidou, K; Turman, C; Soucy, P; Lemaçon, A; Lush, M; Tyrer, JP; Ghoussaini, M; Moradi Marjaneh, M; Jiang, X; Agata, S; Aittomäki, K; Alonso, MR; Andrulis, IL; Anton-Culver, H; Antonenkova, NN; Arason, A; Arndt, V; Aronson, KJ; Arun, BK; Auber, B; Auer, PL; Azzollini, J; Balmaña, J; Barkardottir, RB; Barrowdale, D; Beeghly-Fadiel, A; Benitez, J; Bermisheva, M; Białkowska, K; Blanco, AM; Blomqvist, C; Blot, W; Bogdanova, NV; Bojesen, SE; Bolla, MK; Bonanni, B; Borg, A; Bosse, K; Brauch, H; Brenner, H; Briceno, I; Brock, IW; Brooks-Wilson, A; Brüning, T; Burwinkel, B; Buys, SS; Cai, Q; Caldés, T; Caligo, MA; Camp, NJ; Campbell, I; Canzian, F; Carroll, JS; Carter, BD; Castelao, JE; Chiquette, J; Christiansen, H; Chung, WK; Claes, KBM; Clarke, CL; GEMO Study Collaborators; EMBRACE Collaborators; Collée, JM; Cornelissen, S; Couch, FJ; Cox, A; Cross, SS; Cybulski, C; Czene, K; Daly, MB; de la Hoya, M; Devilee, P; Diez, O; Ding, YC; Dite, GS; Domchek, SM; Dörk, T; Dos-Santos-Silva, I; Droit, A; Dubois, S; Dumont, M; Duran, M; Durcan, L; Dwek, M; Eccles, DM; Engel, C; Eriksson, M; Evans, DG; Fasching, PA; Fletcher, O; Floris, G; Flyger, H; Foretova, L; Foulkes, WD; Friedman, E; Fritschi, L; Frost, D; Gabrielson, M; Gago-Dominguez, M; Gambino, G; Ganz, PA; Gapstur, SM; Garber, J; García-Sáenz, JA; Gaudet, MM; Georgoulias, V; Giles, GG; Glendon, G; Godwin, AK; Goldberg, MS; Goldgar, DE; González-Neira, A; Tibiletti, MG; Greene, MH; Grip, M; Gronwald, J; Grundy, A; Guénel, P; Hahnen, E; Haiman, CA; Håkansson, N; Hall, P; Hamann, U; Harrington, PA; Hartikainen, JM; Hartman, M; He, W; Healey, CS; Heemskerk-Gerritsen, BAM; Heyworth, J; Hillemanns, P; Hogervorst, FBL; Hollestelle, A; Hooning, MJ; Hopper, JL; Howell, A; Huang, G; Hulick, PJ; Imyanitov, EN; KConFab Investigators; HEBON Investigators; ABCTB Investigators; Isaacs, C; Iwasaki, M; Jager, A; Jakimovska, M; Jakubowska, A; James, PA; Janavicius, R; Jankowitz, RC; John, EM; Johnson, N; Jones, ME; Jukkola-Vuorinen, A; Jung, A; Kaaks, R; Kang, D; Kapoor, PM; Karlan, BY; Keeman, R; Kerin, MJ; Khusnutdinova, E; Kiiski, JI; Kirk, J; Kitahara, CM; Ko, Y-D; Konstantopoulou, I; Kosma, V-M; Koutros, S; Kubelka-Sabit, K; Kwong, A; Kyriacou, K; Laitman, Y; Lambrechts, D; Lee, E; Leslie, G; Lester, J; Lesueur, F; Lindblom, A; Lo, W-Y; Long, J; Lophatananon, A; Loud, JT; Lubiński, J; MacInnis, RJ; Maishman, T; Makalic, E; Mannermaa, A; Manoochehri, M; Manoukian, S; Margolin, S; Martinez, ME; Matsuo, K; Maurer, T; Mavroudis, D; Mayes, R; McGuffog, L; McLean, C; Mebirouk, N; Meindl, A; Miller, A; Miller, N; Montagna, M; Moreno, F; Muir, K; Mulligan, AM; Muñoz-Garzon, VM; Muranen, TA; Narod, SA; Nassir, R; Nathanson, KL; Neuhausen, SL; Nevanlinna, H; Neven, P; Nielsen, FC; Nikitina-Zake, L; Norman, A; Offit, K; Olah, E; Olopade, OI; Olsson, H; Orr, N; Osorio, A; Pankratz, VS; Papp, J; Park, SK; Park-Simon, T-W; Parsons, MT; Paul, J; Pedersen, IS; Peissel, B; Peshkin, B; Peterlongo, P; Peto, J; Plaseska-Karanfilska, D; Prajzendanc, K; Prentice, R; Presneau, N; Prokofyeva, D; Pujana, MA; Pylkäs, K; Radice, P; Ramus, SJ; Rantala, J; Rau-Murthy, R; Rennert, G; Risch, HA; Robson, M; Romero, A; Rossing, M; Saloustros, E; Sánchez-Herrero, E; Sandler, DP; Santamariña, M; Saunders, C; Sawyer, EJ; Scheuner, MT; Schmidt, DF; Schmutzler, RK; Schneeweiss, A; Schoemaker, MJ; Schöttker, B; Schürmann, P; Scott, C; Scott, RJ; Senter, L; Seynaeve, CM; Shah, M; Sharma, P; Shen, C-Y; Shu, X-O; Singer, CF; Slavin, TP; Smichkoska, S; Southey, MC; Spinelli, JJ; Spurdle, AB; Stone, J; Stoppa-Lyonnet, D; Sutter, C; Swerdlow, AJ; Tamimi, RM; Tan, YY; Tapper, WJ; Taylor, JA; Teixeira, MR; Tengström, M; Teo, SH; Terry, MB; Teulé, A; Thomassen, M; Thull, DL; Tischkowitz, M; Toland, AE; Tollenaar, RAEM; Tomlinson, I; Torres, D; Torres-Mejía, G; Troester, MA; Truong, T; Tung, N; Tzardi, M; Ulmer, H-U; Vachon, CM; van Asperen, CJ; van der Kolk, LE; van Rensburg, EJ; Vega, A; Viel, A; Vijai, J; Vogel, MJ; Wang, Q; Wappenschmidt, B; Weinberg, CR; Weitzel, JN; Wendt, C; Wildiers, H; Winqvist, R; Wolk, A; Wu, AH; Yannoukakos, D; Zhang, Y; Zheng, W; Hunter, D; Pharoah, PDP; Chang-Claude, J; García-Closas, M; Schmidt, MK; Milne, RL; Kristensen, VN; French, JD; Edwards, SL; Antoniou, AC; Chenevix-Trench, G; Simard, J; Easton, DF; Kraft, P; Dunning, AM (2020-01-07)
      Genome-wide association studies have identified breast cancer risk variants in over 150 genomic regions, but the mechanisms underlying risk remain largely unknown. These regions were explored by combining association ...
    • Mendelian randomisation study of height and body mass index as modifiers of ovarian cancer risk in 22,588 BRCA1 and BRCA2 mutation carriers. 

      Qian, F; Rookus, MA; Leslie, G; Risch, HA; Greene, MH; Aalfs, CM; Adank, MA; Adlard, J; Agnarsson, BA; Ahmed, M; Aittomäki, K; Andrulis, IL; Arnold, N; Arun, BK; Ausems, MGEM; Azzollini, J; Barrowdale, D; Barwell, J; Benitez, J; Białkowska, K; Bonadona, V; Borde, J; Borg, A; Bradbury, AR; Brunet, J; Buys, SS; Caldés, T; Caligo, MA; Campbell, I; Carter, J; Chiquette, J; Chung, WK; Claes, KBM; Collée, JM; Collonge-Rame, M-A; Couch, FJ; Daly, MB; Delnatte, C; Diez, O; Domchek, SM; Dorfling, CM; Eason, J; Easton, DF; Eeles, R; Engel, C; Evans, DG; Faivre, L; Feliubadaló, L; Foretova, L; Friedman, E; Frost, D; Ganz, PA; Garber, J; Garcia-Barberan, V; Gehrig, A; Glendon, G; Godwin, AK; Gómez Garcia, EB; Hamann, U; Hauke, J; Hopper, JL; Hulick, PJ; Imyanitov, EN; Isaacs, C; Izatt, L; Jakubowska, A; Janavicius, R; John, EM; Karlan, BY; Kets, CM; Laitman, Y; Lázaro, C; Leroux, D; Lester, J; Lesueur, F; Loud, JT; Lubiński, J; Łukomska, A; McGuffog, L; Mebirouk, N; Meijers-Heijboer, HEJ; Meindl, A; Miller, A; Montagna, M; Mooij, TM; Mouret-Fourme, E; Nathanson, KL; Nehoray, B; Neuhausen, SL; Nevanlinna, H; Nielsen, FC; Offit, K; Olah, E; Ong, K-R; Oosterwijk, JC; Ottini, L; Parsons, MT; Peterlongo, P; Pfeiler, G; Pradhan, N; Radice, P; Ramus, SJ; Rantala, J; Rennert, G; Robson, M; Rodriguez, GC; Salani, R; Scheuner, MT; Schmutzler, RK; Shah, PD; Side, LE; Simard, J; Singer, CF; Steinemann, D; Stoppa-Lyonnet, D; Tan, YY; Teixeira, MR; Terry, MB; Thomassen, M; Tischkowitz, M; Tognazzo, S; Toland, AE; Tung, N; van Asperen, CJ; van Engelen, K; van Rensburg, EJ; Venat-Bouvet, L; Vierstraete, J; Wagner, G; Walker, L; Weitzel, JN; Yannoukakos, D; KConFab Investigators; HEBON Investigators; GEMO Study Collaborators; EMBRACE Collaborators; Antoniou, AC; Goldgar, DE; Olopade, OI; Chenevix-Trench, G; Rebbeck, TR; Huo, D; CIMBA (2019-07)
      BACKGROUND:Height and body mass index (BMI) are associated with higher ovarian cancer risk in the general population, but whether such associations exist among BRCA1/2 mutation carriers is unknown. METHODS:We applied a ...
    • Polygenic risk scores and breast and epithelial ovarian cancer risks for carriers of BRCA1 and BRCA2 pathogenic variants. 

      Barnes, DR; Rookus, MA; McGuffog, L; Leslie, G; Mooij, TM; Dennis, J; Mavaddat, N; Adlard, J; Ahmed, M; Aittomäki, K; Andrieu, N; Andrulis, IL; Arnold, N; Arun, BK; Azzollini, J; Balmaña, J; Barkardottir, RB; Barrowdale, D; Benitez, J; Berthet, P; Białkowska, K; Blanco, AM; Blok, MJ; Bonanni, B; Boonen, SE; Borg, Å; Bozsik, A; Bradbury, AR; Brennan, P; Brewer, C; Brunet, J; Buys, SS; Caldés, T; Caligo, MA; Campbell, I; Christensen, LL; Chung, WK; Claes, KBM; Colas, C; GEMO Study Collaborators; EMBRACE Collaborators; Collonge-Rame, M-A; Cook, J; Daly, MB; Davidson, R; de la Hoya, M; de Putter, R; Delnatte, C; Devilee, P; Diez, O; Ding, YC; Domchek, SM; Dorfling, CM; Dumont, M; Eeles, R; Ejlertsen, B; Engel, C; Evans, DG; Faivre, L; Foretova, L; Fostira, F; Friedlander, M; Friedman, E; Frost, D; Ganz, PA; Garber, J; Gehrig, A; Gerdes, A-M; Gesta, P; Giraud, S; Glendon, G; Godwin, AK; Goldgar, DE; González-Neira, A; Greene, MH; Gschwantler-Kaulich, D; Hahnen, E; Hamann, U; Hanson, H; Hentschel, J; Hogervorst, FBL; Hooning, MJ; Horvath, J; Hu, C; Hulick, PJ; Imyanitov, EN; kConFab Investigators; HEBON Investigators; GENEPSO Investigators; Isaacs, C; Izatt, L; Izquierdo, A; Jakubowska, A; James, PA; Janavicius, R; John, EM; Joseph, V; Karlan, BY; Kast, K; Koudijs, M; Kruse, TA; Kwong, A; Laitman, Y; Lasset, C; Lazaro, C; Lester, J; Lesueur, F; Liljegren, A; Loud, JT; Lubiński, J; Mai, PL; Manoukian, S; Mari, V; Mebirouk, N; Meijers-Heijboer, HEJ; Meindl, A; Mensenkamp, AR; Miller, A; Montagna, M; Mouret-Fourme, E; Mukherjee, S; Mulligan, AM; Nathanson, KL; Neuhausen, SL; Nevanlinna, H; Niederacher, D; Nielsen, FC; Nikitina-Zake, L; Noguès, C; Olah, E; Olopade, OI; Ong, K-R; O'Shaughnessy-Kirwan, A; Osorio, A; Ott, C-E; Papi, L; Park, SK; Parsons, MT; Pedersen, IS; Peissel, B; Peixoto, A; Peterlongo, P; Pfeiler, G; Phillips, K-A; Prajzendanc, K; Pujana, MA; Radice, P; Ramser, J; Ramus, SJ; Rantala, J; Rennert, G; Risch, HA; Robson, M; Rønlund, K; Salani, R; Schuster, H; Senter, L; Shah, PD; Sharma, P; Side, LE; Singer, CF; Slavin, TP; Soucy, P; Southey, MC; Spurdle, AB; Steinemann, D; Steinsnyder, Z; Stoppa-Lyonnet, D; Sutter, C; Tan, YY; Teixeira, MR; Teo, SH; Thull, DL; Tischkowitz, M; Tognazzo, S; Toland, AE; Trainer, AH; Tung, N; van Engelen, K; van Rensburg, EJ; Vega, A; Vierstraete, J; Wagner, G; Walker, L; Wang-Gohrke, S; Wappenschmidt, B; Weitzel, JN; Yadav, S; Yang, X; Yannoukakos, D; Zimbalatti, D; Offit, K; Thomassen, M; Couch, FJ; Schmutzler, RK; Simard, J; Easton, DF; Chenevix-Trench, G; Antoniou, AC; Consortium of Investigators of Modifiers of BRCA and BRCA2 (2020-07-15)
      PURPOSE:We assessed the associations between population-based polygenic risk scores (PRS) for breast (BC) or epithelial ovarian cancer (EOC) with cancer risks for BRCA1 and BRCA2 pathogenic variant carriers. METHODS:Retrospective ...