Now showing items 1-7 of 7

    • 12 new susceptibility loci for prostate cancer identified by genome-wide association study in Japanese population. 

      Takata, R; Takahashi, A; Fujita, M; Momozawa, Y; Saunders, EJ; Yamada, H; Maejima, K; Nakano, K; Nishida, Y; Hishida, A; Matsuo, K; Wakai, K; Yamaji, T; Sawada, N; Iwasaki, M; Tsugane, S; Sasaki, M; Shimizu, A; Tanno, K; Minegishi, N; Suzuki, K; Matsuda, K; Kubo, M; Inazawa, J; Egawa, S; Haiman, CA; Ogawa, O; Obara, W; Kamatani, Y; Akamatsu, S; Nakagawa, H (2019-09-27)
      Genome-wide association studies (GWAS) have identified ~170 genetic loci associated with prostate cancer (PCa) risk, but most of them were identified in European populations. We here performed a GWAS and replication study ...
    • A genetic study and meta-analysis of the genetic predisposition of prostate cancer in a Chinese population. 

      Marzec, J; Mao, X; Li, M; Wang, M; Feng, N; Gou, X; Wang, G; Sun, Z; Xu, J; Xu, H; Zhang, X; Zhao, S-C; Ren, G; Yu, Y; Wu, Y; Wu, J; Xue, Y; Zhou, B; Zhang, Y; Xu, X; Li, J; He, W; Benlloch, S; Ross-Adams, H; Chen, L; Li, J; Hong, Y; Kote-Jarai, Z; Cui, X; Hou, J; Guo, J; Xu, L; Yin, C; Zhou, Y; Neal, DE; Oliver, T; Cao, G; Zhang, Z; Easton, DF; Chelala, C; PRACTICAL Consortium; CHIPGECS Group; Al Olama, AA; Eeles, RA; Zhang, H; Lu, Y-J (2016-04)
      Prostate cancer predisposition has been extensively investigated in European populations, but there have been few studies of other ethnic groups. To investigate prostate cancer susceptibility in the under-investigated ...
    • Genome-wide association of familial prostate cancer cases identifies evidence for a rare segregating haplotype at 8q24.21. 

      Teerlink, CC; Leongamornlert, D; Dadaev, T; Thomas, A; Farnham, J; Stephenson, RA; Riska, S; McDonnell, SK; Schaid, DJ; Catalona, WJ; Zheng, SL; Cooney, KA; Ray, AM; Zuhlke, KA; Lange, EM; Giles, GG; Southey, MC; Fitzgerald, LM; Rinckleb, A; Luedeke, M; Maier, C; Stanford, JL; Ostrander, EA; Kaikkonen, EM; Sipeky, C; Tammela, T; Schleutker, J; Wiley, KE; Isaacs, SD; Walsh, PC; Isaacs, WB; Xu, J; Cancel-Tassin, G; Cussenot, O; Mandal, D; Laurie, C; Laurie, C; PRACTICAL consortium; International Consortium for Prostate Cancer Genetics; Thibodeau, SN; Eeles, RA; Kote-Jarai, Z; Cannon-Albright, L (2016-08)
      Previous genome-wide association studies (GWAS) of prostate cancer risk focused on cases unselected for family history and have reported over 100 significant associations. The International Consortium for Prostate Cancer ...
    • Identification of nine new susceptibility loci for testicular cancer, including variants near DAZL and PRDM14. 

      Ruark, E; Seal, S; McDonald, H; Zhang, F; Elliot, A; Lau, K; Perdeaux, E; Rapley, E; Eeles, R; Peto, J; Kote-Jarai, Z; Muir, K; Nsengimana, J; Shipley, J; UK Testicular Cancer Collaboration (UKTCC); Bishop, DT; Stratton, MR; Easton, DF; Huddart, RA; Rahman, N; Turnbull, C (2013-06)
      Testicular germ cell tumor (TGCT) is the most common cancer in young men and is notable for its high familial risks. So far, six loci associated with TGCT have been reported. From genome-wide association study (GWAS) ...
    • Large-scale Sequencing of Testicular Germ Cell Tumour (TGCT) Cases Excludes Major TGCT Predisposition Gene. 

      Litchfield, K; Loveday, C; Levy, M; Dudakia, D; Rapley, E; Nsengimana, J; Bishop, DT; Reid, A; Huddart, R; Broderick, P; Houlston, RS; Turnbull, C (2018-06)
      Testicular germ cell tumour (TGCT), the most common cancer in young men, has a significant heritable basis that has long raised questions as to the existence of underlying major high-penetrance susceptibility gene(s). To ...
    • REVEL: An Ensemble Method for Predicting the Pathogenicity of Rare Missense Variants. 

      Ioannidis, NM; Rothstein, JH; Pejaver, V; Middha, S; McDonnell, SK; Baheti, S; Musolf, A; Li, Q; Holzinger, E; Karyadi, D; Cannon-Albright, LA; Teerlink, CC; Stanford, JL; Isaacs, WB; Xu, J; Cooney, KA; Lange, EM; Schleutker, J; Carpten, JD; Powell, IJ; Cussenot, O; Cancel-Tassin, G; Giles, GG; MacInnis, RJ; Maier, C; Hsieh, C-L; Wiklund, F; Catalona, WJ; Foulkes, WD; Mandal, D; Eeles, RA; Kote-Jarai, Z; Bustamante, CD; Schaid, DJ; Hastie, T; Ostrander, EA; Bailey-Wilson, JE; Radivojac, P; Thibodeau, SN; Whittemore, AS; Sieh, W (2016-10)
      The vast majority of coding variants are rare, and assessment of the contribution of rare variants to complex traits is hampered by low statistical power and limited functional data. Improved methods for predicting the ...
    • Two Novel Susceptibility Loci for Prostate Cancer in Men of African Ancestry. 

      Conti, DV; Wang, K; Sheng, X; Bensen, JT; Hazelett, DJ; Cook, MB; Ingles, SA; Kittles, RA; Strom, SS; Rybicki, BA; Nemesure, B; Isaacs, WB; Stanford, JL; Zheng, W; Sanderson, M; John, EM; Park, JY; Xu, J; Stevens, VL; Berndt, SI; Huff, CD; Wang, Z; Yeboah, ED; Tettey, Y; Biritwum, RB; Adjei, AA; Tay, E; Truelove, A; Niwa, S; Sellers, TA; Yamoah, K; Murphy, AB; Crawford, DC; Gapstur, SM; Bush, WS; Aldrich, MC; Cussenot, O; Petrovics, G; Cullen, J; Neslund-Dudas, C; Stern, MC; Jarai, Z-K; Govindasami, K; Chokkalingam, AP; Hsing, AW; Goodman, PJ; Hoffmann, T; Drake, BF; Hu, JJ; Clark, PE; Van Den Eeden, SK; Blanchet, P; Fowke, JH; Casey, G; Hennis, AJM; Han, Y; Lubwama, A; Thompson, IM; Leach, R; Easton, DF; Schumacher, F; Van den Berg, DJ; Gundell, SM; Stram, A; Wan, P; Xia, L; Pooler, LC; Mohler, JL; Fontham, ETH; Smith, GJ; Taylor, JA; Srivastava, S; Eeles, RA; Carpten, J; Kibel, AS; Multigner, L; Parent, M-E; Menegaux, F; Cancel-Tassin, G; Klein, EA; Brureau, L; Stram, DO; Watya, S; Chanock, SJ; Witte, JS; Blot, WJ; Henderson, BE; Haiman, CA; PRACTICAL/ELLIPSE Consortium (2017-08)
      Prostate cancer incidence is 1.6-fold higher in African Americans than in other populations. The risk factors that drive this disparity are unknown and potentially consist of social, environmental, and genetic influences. ...