Browsing Radiotherapy and Imaging by subject "gamma-Glutamyl Hydrolase"

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Detection of the prodrug-activating enzyme carboxypeptidase G2 activity with chemical exchange saturation transfer magnetic resonance.

Jamin, Y; Eykyn, TR; Poon, E; Springer, CJ; Robinson, SP (2014-04)

<h4>Purpose</h4>The purpose of this study is to evaluate if the differential exchange rates with bulk water between amine and amide protons can be exploited using chemical exchange saturation transfer magnetic resonance ...
Noninvasive detection of carboxypeptidase G2 activity in vivo.

Jamin, Y; Smyth, L; Robinson, SP; Poon, ESC; Eykyn, TR; Springer, CJ; Leach, MO; Payne, GS (2011-05)

The pseudomonad protein, carboxypeptidase G2 (CPG2), is a prodrug-activating enzyme utilized in the targeted chemotherapy strategies of antibody- and gene-directed enzyme prodrug therapy (ADEPT and GDEPT). We have developed ...

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