Now showing items 1-5 of 5

    • Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types. 

      Kar, SP; Beesley, J; Amin Al Olama, A; Michailidou, K; Tyrer, J; Kote-Jarai, Z; Lawrenson, K; Lindstrom, S; Ramus, SJ; Thompson, DJ; ABCTB Investigators; Kibel, AS; Dansonka-Mieszkowska, A; Michael, A; Dieffenbach, AK; Gentry-Maharaj, A; Whittemore, AS; Wolk, A; Monteiro, A; Peixoto, A; Kierzek, A; Cox, A; Rudolph, A; Gonzalez-Neira, A; Wu, AH; Lindblom, A; Swerdlow, A; AOCS Study Group & Australian Cancer Study (Ovarian Cancer); APCB BioResource; Ziogas, A; Ekici, AB; Burwinkel, B; Karlan, BY; Nordestgaard, BG; Blomqvist, C; Phelan, C; McLean, C; Pearce, CL; Vachon, C; Cybulski, C; Slavov, C; Stegmaier, C; Maier, C; Ambrosone, CB; Høgdall, CK; Teerlink, CC; Kang, D; Tessier, DC; Schaid, DJ; Stram, DO; Cramer, DW; Neal, DE; Eccles, D; Flesch-Janys, D; Edwards, DRV; Wokozorczyk, D; Levine, DA; Yannoukakos, D; Sawyer, EJ; Bandera, EV; Poole, EM; Goode, EL; Khusnutdinova, E; Høgdall, E; Song, F; Bruinsma, F; Heitz, F; Modugno, F; Hamdy, FC; Wiklund, F; Giles, GG; Olsson, H; Wildiers, H; Ulmer, H-U; Pandha, H; Risch, HA; Darabi, H; Salvesen, HB; Nevanlinna, H; Gronberg, H; Brenner, H; Brauch, H; Anton-Culver, H; Song, H; Lim, H-Y; McNeish, I; Campbell, I; Vergote, I; Gronwald, J; Lubiński, J; Stanford, JL; Benítez, J; Doherty, JA; Permuth, JB; Chang-Claude, J; Donovan, JL; Dennis, J; Schildkraut, JM; Schleutker, J; Hopper, JL; Kupryjanczyk, J; Park, JY; Figueroa, J; Clements, JA; Knight, JA; Peto, J; Cunningham, JM; Pow-Sang, J; Batra, J; Czene, K; Lu, KH; Herkommer, K; Khaw, K-T; kConFab Investigators; Matsuo, K; Muir, K; Offitt, K; Chen, K; Moysich, KB; Aittomäki, K; Odunsi, K; Kiemeney, LA; Massuger, LFAG; Fitzgerald, LM; Cook, LS; Cannon-Albright, L; Hooning, MJ; Pike, MC; Bolla, MK; Luedeke, M; Teixeira, MR; Goodman, MT; Schmidt, MK; Riggan, M; Aly, M; Rossing, MA; Beckmann, MW; Moisse, M; Sanderson, M; Southey, MC; Jones, M; Lush, M; Hildebrandt, MAT; Hou, M-F; Schoemaker, MJ; Garcia-Closas, M; Bogdanova, N; Rahman, N; NBCS Investigators; Le, ND; Orr, N; Wentzensen, N; Pashayan, N; Peterlongo, P; Guénel, P; Brennan, P; Paulo, P; Webb, PM; Broberg, P; Fasching, PA; Devilee, P; Wang, Q; Cai, Q; Li, Q; Kaneva, R; Butzow, R; Kopperud, RK; Schmutzler, RK; Stephenson, RA; MacInnis, RJ; Hoover, RN; Winqvist, R; Ness, R; Milne, RL; Travis, RC; Benlloch, S; Olson, SH; McDonnell, SK; Tworoger, SS; Maia, S; Berndt, S; Lee, SC; Teo, S-H; Thibodeau, SN; Bojesen, SE; Gapstur, SM; Kjær, SK; Pejovic, T; Tammela, TLJ; GENICA Network; PRACTICAL consortium; Dörk, T; Brüning, T; Wahlfors, T; Key, TJ; Edwards, TL; Menon, U; Hamann, U; Mitev, V; Kosma, V-M; Setiawan, VW; Kristensen, V; Arndt, V; Vogel, W; Zheng, W; Sieh, W; Blot, WJ; Kluzniak, W; Shu, X-O; Gao, Y-T; Schumacher, F; Freedman, ML; Berchuck, A; Dunning, AM; Simard, J; Haiman, CA; Spurdle, A; Sellers, TA; Hunter, DJ; Henderson, BE; Kraft, P; Chanock, SJ; Couch, FJ; Hall, P; Gayther, SA; Easton, DF; Chenevix-Trench, G; Eeles, R; Pharoah, PDP; Lambrechts, D (2016-09)
      Unlabelled Breast, ovarian, and prostate cancers are hormone-related and may have a shared genetic basis, but this has not been investigated systematically by genome-wide association (GWA) studies. Meta-analyses combining ...
    • Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2. 

      Silvestri, V; Barrowdale, D; Mulligan, AM; Neuhausen, SL; Fox, S; Karlan, BY; Mitchell, G; James, P; Thull, DL; Zorn, KK; Carter, NJ; Nathanson, KL; Domchek, SM; Rebbeck, TR; Ramus, SJ; Nussbaum, RL; Olopade, OI; Rantala, J; Yoon, S-Y; Caligo, MA; Spugnesi, L; Bojesen, A; Pedersen, IS; Thomassen, M; Jensen, UB; Toland, AE; Senter, L; Andrulis, IL; Glendon, G; Hulick, PJ; Imyanitov, EN; Greene, MH; Mai, PL; Singer, CF; Rappaport-Fuerhauser, C; Kramer, G; Vijai, J; Offit, K; Robson, M; Lincoln, A; Jacobs, L; Machackova, E; Foretova, L; Navratilova, M; Vasickova, P; Couch, FJ; Hallberg, E; Ruddy, KJ; Sharma, P; Kim, S-W; kConFab Investigators; Teixeira, MR; Pinto, P; Montagna, M; Matricardi, L; Arason, A; Johannsson, OT; Barkardottir, RB; Jakubowska, A; Lubinski, J; Izquierdo, A; Pujana, MA; Balmaña, J; Diez, O; Ivady, G; Papp, J; Olah, E; Kwong, A; Hereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON); Nevanlinna, H; Aittomäki, K; Perez Segura, P; Caldes, T; Van Maerken, T; Poppe, B; Claes, KBM; Isaacs, C; Elan, C; Lasset, C; Stoppa-Lyonnet, D; Barjhoux, L; Belotti, M; Meindl, A; Gehrig, A; Sutter, C; Engel, C; Niederacher, D; Steinemann, D; Hahnen, E; Kast, K; Arnold, N; Varon-Mateeva, R; Wand, D; Godwin, AK; Evans, DG; Frost, D; Perkins, J; Adlard, J; Izatt, L; Platte, R; Eeles, R; Ellis, S; EMBRACE; Hamann, U; Garber, J; Fostira, F; Fountzilas, G; Pasini, B; Giannini, G; Rizzolo, P; Russo, A; Cortesi, L; Papi, L; Varesco, L; Palli, D; Zanna, I; Savarese, A; Radice, P; Manoukian, S; Peissel, B; Barile, M; Bonanni, B; Viel, A; Pensotti, V; Tommasi, S; Peterlongo, P; Weitzel, JN; Osorio, A; Benitez, J; McGuffog, L; Healey, S; Gerdes, A-M; Ejlertsen, B; Hansen, TVO; Steele, L; Ding, YC; Tung, N; Janavicius, R; Goldgar, DE; Buys, SS; Daly, MB; Bane, A; Terry, MB; John, EM; Southey, M; Easton, DF; Chenevix-Trench, G; Antoniou, AC; Ottini, L (2016-02-09)
      Background BRCA1 and, more commonly, BRCA2 mutations are associated with increased risk of male breast cancer (MBC). However, only a paucity of data exists on the pathology of breast cancers (BCs) in men with BRCA1/2 ...
    • Polygenic risk scores and breast and epithelial ovarian cancer risks for carriers of BRCA1 and BRCA2 pathogenic variants. 

      Barnes, DR; Rookus, MA; McGuffog, L; Leslie, G; Mooij, TM; Dennis, J; Mavaddat, N; Adlard, J; Ahmed, M; Aittomäki, K; Andrieu, N; Andrulis, IL; Arnold, N; Arun, BK; Azzollini, J; Balmaña, J; Barkardottir, RB; Barrowdale, D; Benitez, J; Berthet, P; Białkowska, K; Blanco, AM; Blok, MJ; Bonanni, B; Boonen, SE; Borg, Å; Bozsik, A; Bradbury, AR; Brennan, P; Brewer, C; Brunet, J; Buys, SS; Caldés, T; Caligo, MA; Campbell, I; Christensen, LL; Chung, WK; Claes, KBM; Colas, C; GEMO Study Collaborators; EMBRACE Collaborators; Collonge-Rame, M-A; Cook, J; Daly, MB; Davidson, R; de la Hoya, M; de Putter, R; Delnatte, C; Devilee, P; Diez, O; Ding, YC; Domchek, SM; Dorfling, CM; Dumont, M; Eeles, R; Ejlertsen, B; Engel, C; Evans, DG; Faivre, L; Foretova, L; Fostira, F; Friedlander, M; Friedman, E; Frost, D; Ganz, PA; Garber, J; Gehrig, A; Gerdes, A-M; Gesta, P; Giraud, S; Glendon, G; Godwin, AK; Goldgar, DE; González-Neira, A; Greene, MH; Gschwantler-Kaulich, D; Hahnen, E; Hamann, U; Hanson, H; Hentschel, J; Hogervorst, FBL; Hooning, MJ; Horvath, J; Hu, C; Hulick, PJ; Imyanitov, EN; kConFab Investigators; HEBON Investigators; GENEPSO Investigators; Isaacs, C; Izatt, L; Izquierdo, A; Jakubowska, A; James, PA; Janavicius, R; John, EM; Joseph, V; Karlan, BY; Kast, K; Koudijs, M; Kruse, TA; Kwong, A; Laitman, Y; Lasset, C; Lazaro, C; Lester, J; Lesueur, F; Liljegren, A; Loud, JT; Lubiński, J; Mai, PL; Manoukian, S; Mari, V; Mebirouk, N; Meijers-Heijboer, HEJ; Meindl, A; Mensenkamp, AR; Miller, A; Montagna, M; Mouret-Fourme, E; Mukherjee, S; Mulligan, AM; Nathanson, KL; Neuhausen, SL; Nevanlinna, H; Niederacher, D; Nielsen, FC; Nikitina-Zake, L; Noguès, C; Olah, E; Olopade, OI; Ong, K-R; O'Shaughnessy-Kirwan, A; Osorio, A; Ott, C-E; Papi, L; Park, SK; Parsons, MT; Pedersen, IS; Peissel, B; Peixoto, A; Peterlongo, P; Pfeiler, G; Phillips, K-A; Prajzendanc, K; Pujana, MA; Radice, P; Ramser, J; Ramus, SJ; Rantala, J; Rennert, G; Risch, HA; Robson, M; Rønlund, K; Salani, R; Schuster, H; Senter, L; Shah, PD; Sharma, P; Side, LE; Singer, CF; Slavin, TP; Soucy, P; Southey, MC; Spurdle, AB; Steinemann, D; Steinsnyder, Z; Stoppa-Lyonnet, D; Sutter, C; Tan, YY; Teixeira, MR; Teo, SH; Thull, DL; Tischkowitz, M; Tognazzo, S; Toland, AE; Trainer, AH; Tung, N; van Engelen, K; van Rensburg, EJ; Vega, A; Vierstraete, J; Wagner, G; Walker, L; Wang-Gohrke, S; Wappenschmidt, B; Weitzel, JN; Yadav, S; Yang, X; Yannoukakos, D; Zimbalatti, D; Offit, K; Thomassen, M; Couch, FJ; Schmutzler, RK; Simard, J; Easton, DF; Chenevix-Trench, G; Antoniou, AC; Consortium of Investigators of Modifiers of BRCA and BRCA2 (2020-10)
      Purpose We assessed the associations between population-based polygenic risk scores (PRS) for breast (BC) or epithelial ovarian cancer (EOC) with cancer risks for BRCA1 and BRCA2 pathogenic variant carriers.Methods ...
    • Refined histopathological predictors of BRCA1 and BRCA2 mutation status: a large-scale analysis of breast cancer characteristics from the BCAC, CIMBA, and ENIGMA consortia. 

      Spurdle, AB; Couch, FJ; Parsons, MT; McGuffog, L; Barrowdale, D; Bolla, MK; Wang, Q; Healey, S; Schmutzler, R; Wappenschmidt, B; Rhiem, K; Hahnen, E; Engel, C; Meindl, A; Ditsch, N; Arnold, N; Plendl, H; Niederacher, D; Sutter, C; Wang-Gohrke, S; Steinemann, D; Preisler-Adams, S; Kast, K; Varon-Mateeva, R; Ellis, S; Frost, D; Platte, R; Perkins, J; Evans, DG; Izatt, L; Eeles, R; Adlard, J; Davidson, R; Cole, T; Scuvera, G; Manoukian, S; Bonanni, B; Mariette, F; Fortuzzi, S; Viel, A; Pasini, B; Papi, L; Varesco, L; Balleine, R; Nathanson, KL; Domchek, SM; Offitt, K; Jakubowska, A; Lindor, N; Thomassen, M; Jensen, UB; Rantala, J; Borg, Å; Andrulis, IL; Miron, A; Hansen, TVO; Caldes, T; Neuhausen, SL; Toland, AE; Nevanlinna, H; Montagna, M; Garber, J; Godwin, AK; Osorio, A; Factor, RE; Terry, MB; Rebbeck, TR; Karlan, BY; Southey, M; Rashid, MU; Tung, N; Pharoah, PDP; Blows, FM; Dunning, AM; Provenzano, E; Hall, P; Czene, K; Schmidt, MK; Broeks, A; Cornelissen, S; Verhoef, S; Fasching, PA; Beckmann, MW; Ekici, AB; Slamon, DJ; Bojesen, SE; Nordestgaard, BG; Nielsen, SF; Flyger, H; Chang-Claude, J; Flesch-Janys, D; Rudolph, A; Seibold, P; Aittomäki, K; Muranen, TA; Heikkilä, P; Blomqvist, C; Figueroa, J; Chanock, SJ; Brinton, L; Lissowska, J; Olson, JE; Pankratz, VS; John, EM; Whittemore, AS; West, DW; Hamann, U; Torres, D; Ulmer, HU; Rüdiger, T; Devilee, P; Tollenaar, RAEM; Seynaeve, C; Van Asperen, CJ; Eccles, DM; Tapper, WJ; Durcan, L; Jones, L; Peto, J; dos-Santos-Silva, I; Fletcher, O; Johnson, N; Dwek, M; Swann, R; Bane, AL; Glendon, G; Mulligan, AM; Giles, GG; Milne, RL; Baglietto, L; McLean, C; Carpenter, J; Clarke, C; Scott, R; Brauch, H; Brüning, T; Ko, Y-D; Cox, A; Cross, SS; Reed, MWR; Lubinski, J; Jaworska-Bieniek, K; Durda, K; Gronwald, J; Dörk, T; Bogdanova, N; Park-Simon, T-W; Hillemanns, P; Haiman, CA; Henderson, BE; Schumacher, F; Le Marchand, L; Burwinkel, B; Marme, F; Surovy, H; Yang, R; Anton-Culver, H; Ziogas, A; Hooning, MJ; Collée, JM; Martens, JWM; Tilanus-Linthorst, MMA; Brenner, H; Dieffenbach, AK; Arndt, V; Stegmaier, C; Winqvist, R; Pylkäs, K; Jukkola-Vuorinen, A; Grip, M; Lindblom, A; Margolin, S; Joseph, V; Robson, M; Rau-Murthy, R; González-Neira, A; Arias, JI; Zamora, P; Benítez, J; Mannermaa, A; Kataja, V; Kosma, V-M; Hartikainen, JM; Peterlongo, P; Zaffaroni, D; Barile, M; Capra, F; Radice, P; Teo, SH; Easton, DF; Antoniou, AC; Chenevix-Trench, G; Goldgar, DE; ABCTB Investigators; EMBRACE Group; GENICA Network; HEBON Group; kConFab Investigators (2014-12-23)
      Introduction The distribution of histopathological features of invasive breast tumors in BRCA1 or BRCA2 germline mutation carriers differs from that of individuals with no known mutation. Histopathological features thus ...
    • Risk-reducing salpingo-oophorectomy, natural menopause, and breast cancer risk: an international prospective cohort of BRCA1 and BRCA2 mutation carriers. 

      Mavaddat, N; Antoniou, AC; Mooij, TM; Hooning, MJ; Heemskerk-Gerritsen, BA; GENEPSO; Noguès, C; Gauthier-Villars, M; Caron, O; Gesta, P; Pujol, P; Lortholary, A; EMBRACE; Barrowdale, D; Frost, D; Evans, DG; Izatt, L; Adlard, J; Eeles, R; Brewer, C; Tischkowitz, M; Henderson, A; Cook, J; Eccles, D; HEBON; van Engelen, K; Mourits, MJE; Ausems, MGEM; Koppert, LB; Hopper, JL; John, EM; Chung, WK; Andrulis, IL; Daly, MB; Buys, SS; kConFab Investigators; Benitez, J; Caldes, T; Jakubowska, A; Simard, J; Singer, CF; Tan, Y; Olah, E; Navratilova, M; Foretova, L; Gerdes, A-M; Roos-Blom, M-J; Van Leeuwen, FE; Arver, B; Olsson, H; Schmutzler, RK; Engel, C; Kast, K; Phillips, K-A; Terry, MB; Milne, RL; Goldgar, DE; Rookus, MA; Andrieu, N; Easton, DF; IBCCS; kConFab; BCFR (2020-01-16)
      BACKGROUND:The effect of risk-reducing salpingo-oophorectomy (RRSO) on breast cancer risk for BRCA1 and BRCA2 mutation carriers is uncertain. Retrospective analyses have suggested a protective effect but may be substantially ...