Now showing items 1-3 of 3

    • APOBEC3B-mediated corruption of the tumor cell immunopeptidome induces heteroclitic neoepitopes for cancer immunotherapy. 

      Driscoll, CB; Schuelke, MR; Kottke, T; Thompson, JM; Wongthida, P; Tonne, JM; Huff, AL; Miller, A; Shim, KG; Molan, A; Wetmore, C; Selby, P; Samson, A; Harrington, K; Pandha, H; Melcher, A; Pulido, JS; Harris, R; Evgin, L; Vile, RG (2020-02-07)
      APOBEC3B, an anti-viral cytidine deaminase which induces DNA mutations, has been implicated as a mediator of cancer evolution and therapeutic resistance. Mutational plasticity also drives generation of neoepitopes, which ...
    • Genome-wide association study implicates immune dysfunction in the development of Hodgkin lymphoma. 

      Sud, A; Thomsen, H; Orlando, G; Försti, A; Law, PJ; Broderick, P; Cooke, R; Hariri, F; Pastinen, T; Easton, DF; Pharoah, PDP; Dunning, AM; Peto, J; Canzian, F; Eeles, R; Kote-Jarai, Z; Muir, K; Pashayan, N; Campa, D; PRACTICAL Consortium; Hoffmann, P; Nöthen, MM; Jöckel, K-H; von Strandmann, EP; Swerdlow, AJ; Engert, A; Orr, N; Hemminki, K; Houlston, RS (2018-11)
      To further our understanding of inherited susceptibility to Hodgkin lymphoma (HL), we performed a meta-analysis of 7 genome-wide association studies totaling 5325 HL cases and 22 423 control patients. We identify 5 new HL ...
    • Subversion of NK-cell and TNFα Immune Surveillance Drives Tumor Recurrence. 

      Kottke, T; Evgin, L; Shim, KG; Rommelfanger, D; Boisgerault, N; Zaidi, S; Diaz, RM; Thompson, J; Ilett, E; Coffey, M; Selby, P; Pandha, H; Harrington, K; Melcher, A; Vile, R (2017-11)
      Understanding how incompletely cleared primary tumors transition from minimal residual disease (MRD) into treatment-resistant, immune-invisible recurrences has major clinical significance. We show here that this transition ...