Now showing items 1-4 of 4

    • Dietary fat and early-onset prostate cancer risk. 

      Lophatananon, A; Archer, J; Easton, D; Pocock, R; Dearnaley, D; Guy, M; Kote-Jarai, Z; O'Brien, L; Wilkinson, RA; Hall, AL; Sawyer, E; Page, E; Liu, J-F; Barratt, S; Rahman, AA; UK Genetic Prostate Cancer Study Collaborators; British Association of Urological Surgeons' Section of Oncology; Eeles, R; Muir, K (2010-05)
      The UK incidence of prostate cancer has been increasing in men aged < 60 years. Migrant studies and global and secular variation in incidence suggest that modifiable factors, including a high-fat diet, may contribute to ...
    • Gene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array. 

      Saunders, EJ; Dadaev, T; Leongamornlert, DA; Al Olama, AA; Benlloch, S; Giles, GG; Wiklund, F; Gronberg, H; Haiman, CA; Schleutker, J; Nordestgaard, BG; Travis, RC; Neal, D; Pasayan, N; Khaw, K-T; Stanford, JL; Blot, WJ; Thibodeau, SN; Maier, C; Kibel, AS; Cybulski, C; Cannon-Albright, L; Brenner, H; Park, JY; Kaneva, R; Batra, J; Teixeira, MR; Pandha, H; Govindasami, K; Muir, K; UK Genetic Prostate Cancer Study Collaborators; UK ProtecT Study Collaborators; PRACTICAL Consortium; Easton, DF; Eeles, RA; Kote-Jarai, Z (2016-04)
      BACKGROUND:Germline mutations within DNA-repair genes are implicated in susceptibility to multiple forms of cancer. For prostate cancer (PrCa), rare mutations in BRCA2 and BRCA1 give rise to moderately elevated risk, whereas ...
    • Homeobox B13 G84E Mutation and Prostate Cancer Risk. 

      Nyberg, T; Govindasami, K; Leslie, G; Dadaev, T; Bancroft, E; Ni Raghallaigh, H; Brook, MN; Hussain, N; Keating, D; Lee, A; McMahon, R; Morgan, A; Mullen, A; Osborne, A; Rageevakumar, R; UK Genetic Prostate Cancer Study Collaborators; Kote-Jarai, Z; Eeles, R; Antoniou, AC (2019-05)
      BACKGROUND:The homeobox B13 (HOXB13) G84E mutation has been recommended for use in genetic counselling for prostate cancer (PCa), but the magnitude of PCa risk conferred by this mutation is uncertain. OBJECTIVE:To obtain ...
    • Use of a Novel Nonparametric Version of DEPTH to Identify Genomic Regions Associated with Prostate Cancer Risk. 

      MacInnis, RJ; Schmidt, DF; Makalic, E; Severi, G; FitzGerald, LM; Reumann, M; Kapuscinski, MK; Kowalczyk, A; Zhou, Z; Goudey, B; Qian, G; Bui, QM; Park, DJ; Freeman, A; Southey, MC; Al Olama, AA; Kote-Jarai, Z; Eeles, RA; Hopper, JL; Giles, GG; UK Genetic Prostate Cancer Study Collaborators (2016-12)
      We have developed a genome-wide association study analysis method called DEPTH (DEPendency of association on the number of Top Hits) to identify genomic regions potentially associated with disease by considering overlapping ...