Show simple item record

dc.contributor.authorBrunt, AMen_US
dc.contributor.authorWheatley, Den_US
dc.contributor.authorYarnold, Jen_US
dc.contributor.authorSomaiah, Nen_US
dc.contributor.authorKelly, Sen_US
dc.contributor.authorHarnett, Aen_US
dc.contributor.authorColes, Cen_US
dc.contributor.authorGoodman, Aen_US
dc.contributor.authorBahl, Aen_US
dc.contributor.authorChurn, Men_US
dc.contributor.authorZotova, Ren_US
dc.contributor.authorSydenham, Men_US
dc.contributor.authorGriffin, CLen_US
dc.contributor.authorMorden, JPen_US
dc.contributor.authorBliss, JMen_US
dc.date.accessioned2016-08-26T15:24:57Z
dc.date.issued2016-07en_US
dc.identifier.citationRadiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2016, 120 (1), pp. 114 - 118en_US
dc.identifier.issn0167-8140en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/81
dc.identifier.eissn1879-0887en_US
dc.identifier.doi10.1016/j.radonc.2016.02.027en_US
dc.description.abstractFAST-Forward is a phase 3 clinical trial testing a 1-week course of whole breast radiotherapy against the UK standard 3-week regimen after primary surgery for early breast cancer. Two acute skin toxicity substudies were undertaken to test the safety of the test schedules with respect to early skin reactions.Patients were randomly allocated to 40Gy/15 fractions (F)/3-weeks, 27Gy/5F/1-week or 26Gy/5F/1-week. Acute breast skin reactions were graded using RTOG (first substudy) and CTCAE criteria v4.03 (second substudy) weekly during treatment and for 4weeks after treatment ended. Primary endpoint was the proportion of patients within each treatment group with grade ⩾3 toxicity (RTOG and CTCAE, respectively) at any time from the start of radiotherapy to 4weeks after completion.190 and 162 patients were recruited. In the first substudy, evaluable patients with grade 3 RTOG toxicity were: 40Gy/15F 6/44 (13.6%); 27Gy/5F 5/51 (9.8%); 26Gy/5F 3/52 (5.8%). In the second substudy, evaluable patients with grade 3 CTCAE toxicity were: 40Gy/15F 0/43; 27Gy/5F 1/41 (2.4%); 26Gy/5F 0/53.Acute breast skin reactions with two 1-week schedules of whole breast radiotherapy under test in FAST-Forward were mild.en_US
dc.formatPrint-Electronicen_US
dc.format.extent114 - 118en_US
dc.languageengen_US
dc.language.isoengen_US
dc.subjectFAST-Forward Trial Management Groupen_US
dc.titleAcute skin toxicity associated with a 1-week schedule of whole breast radiotherapy compared with a standard 3-week regimen delivered in the UK FAST-Forward Trial.en_US
dc.typeJournal Article
dcterms.dateAccepted2016-02-22en_US
rioxxterms.versionofrecord10.1016/j.radonc.2016.02.027en_US
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0en_US
rioxxterms.licenseref.startdate2016-07en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfRadiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncologyen_US
pubs.issue1en_US
pubs.notesNo embargoen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Biology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Biology/Targeted Therapy
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Clinical Trials & Statistics Unit
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Targeted Therapy
pubs.volume120en_US
pubs.embargo.termsNo embargoen_US
icr.researchteamClinical Trials & Statistics Uniten_US
icr.researchteamTargeted Therapyen_US
dc.contributor.icrauthorBliss, Judithen_US
dc.contributor.icrauthorYarnold, Johnen_US
dc.contributor.icrauthorMorden, James Peteren_US
dc.contributor.icrauthorGriffin, Clareen_US
dc.contributor.icrauthorSomaiah, Navitaen_US
dc.contributor.icrauthorSydenham, Marken_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record