dc.contributor.author | Michailidou, K | |
dc.contributor.author | Hall, P | |
dc.contributor.author | Gonzalez-Neira, A | |
dc.contributor.author | Ghoussaini, M | |
dc.contributor.author | Dennis, J | |
dc.contributor.author | Milne, RL | |
dc.contributor.author | Schmidt, MK | |
dc.contributor.author | Chang-Claude, J | |
dc.contributor.author | Bojesen, SE | |
dc.contributor.author | Bolla, MK | |
dc.contributor.author | Wang, Q | |
dc.contributor.author | Dicks, E | |
dc.contributor.author | Lee, A | |
dc.contributor.author | Turnbull, C | |
dc.contributor.author | Rahman, N | |
dc.contributor.author | Breast and Ovarian Cancer Susceptibility Collaboration, | |
dc.contributor.author | Fletcher, O | |
dc.contributor.author | Peto, J | |
dc.contributor.author | Gibson, L | |
dc.contributor.author | Dos Santos Silva, I | |
dc.contributor.author | Nevanlinna, H | |
dc.contributor.author | Muranen, TA | |
dc.contributor.author | Aittomäki, K | |
dc.contributor.author | Blomqvist, C | |
dc.contributor.author | Czene, K | |
dc.contributor.author | Irwanto, A | |
dc.contributor.author | Liu, J | |
dc.contributor.author | Waisfisz, Q | |
dc.contributor.author | Meijers-Heijboer, H | |
dc.contributor.author | Adank, M | |
dc.contributor.author | Hereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON), | |
dc.contributor.author | van der Luijt, RB | |
dc.contributor.author | Hein, R | |
dc.contributor.author | Dahmen, N | |
dc.contributor.author | Beckman, L | |
dc.contributor.author | Meindl, A | |
dc.contributor.author | Schmutzler, RK | |
dc.contributor.author | Müller-Myhsok, B | |
dc.contributor.author | Lichtner, P | |
dc.contributor.author | Hopper, JL | |
dc.contributor.author | Southey, MC | |
dc.contributor.author | Makalic, E | |
dc.contributor.author | Schmidt, DF | |
dc.contributor.author | Uitterlinden, AG | |
dc.contributor.author | Hofman, A | |
dc.contributor.author | Hunter, DJ | |
dc.contributor.author | Chanock, SJ | |
dc.contributor.author | Vincent, D | |
dc.contributor.author | Bacot, F | |
dc.contributor.author | Tessier, DC | |
dc.contributor.author | Canisius, S | |
dc.contributor.author | Wessels, LFA | |
dc.contributor.author | Haiman, CA | |
dc.contributor.author | Shah, M | |
dc.contributor.author | Luben, R | |
dc.contributor.author | Brown, J | |
dc.contributor.author | Luccarini, C | |
dc.contributor.author | Schoof, N | |
dc.contributor.author | Humphreys, K | |
dc.contributor.author | Li, J | |
dc.contributor.author | Nordestgaard, BG | |
dc.contributor.author | Nielsen, SF | |
dc.contributor.author | Flyger, H | |
dc.contributor.author | Couch, FJ | |
dc.contributor.author | Wang, X | |
dc.contributor.author | Vachon, C | |
dc.contributor.author | Stevens, KN | |
dc.contributor.author | Lambrechts, D | |
dc.contributor.author | Moisse, M | |
dc.contributor.author | Paridaens, R | |
dc.contributor.author | Christiaens, M-R | |
dc.contributor.author | Rudolph, A | |
dc.contributor.author | Nickels, S | |
dc.contributor.author | Flesch-Janys, D | |
dc.contributor.author | Johnson, N | |
dc.contributor.author | Aitken, Z | |
dc.contributor.author | Aaltonen, K | |
dc.contributor.author | Heikkinen, T | |
dc.contributor.author | Broeks, A | |
dc.contributor.author | Veer, LJV | |
dc.contributor.author | van der Schoot, CE | |
dc.contributor.author | Guénel, P | |
dc.contributor.author | Truong, T | |
dc.contributor.author | Laurent-Puig, P | |
dc.contributor.author | Menegaux, F | |
dc.contributor.author | Marme, F | |
dc.contributor.author | Schneeweiss, A | |
dc.contributor.author | Sohn, C | |
dc.contributor.author | Burwinkel, B | |
dc.contributor.author | Zamora, MP | |
dc.contributor.author | Perez, JIA | |
dc.contributor.author | Pita, G | |
dc.contributor.author | Alonso, MR | |
dc.contributor.author | Cox, A | |
dc.contributor.author | Brock, IW | |
dc.contributor.author | Cross, SS | |
dc.contributor.author | Reed, MWR | |
dc.contributor.author | Sawyer, EJ | |
dc.contributor.author | Tomlinson, I | |
dc.contributor.author | Kerin, MJ | |
dc.contributor.author | Miller, N | |
dc.contributor.author | Henderson, BE | |
dc.contributor.author | Schumacher, F | |
dc.contributor.author | Le Marchand, L | |
dc.contributor.author | Andrulis, IL | |
dc.contributor.author | Knight, JA | |
dc.contributor.author | Glendon, G | |
dc.contributor.author | Mulligan, AM | |
dc.contributor.author | kConFab Investigators, | |
dc.contributor.author | Australian Ovarian Cancer Study Group, | |
dc.contributor.author | Lindblom, A | |
dc.contributor.author | Margolin, S | |
dc.contributor.author | Hooning, MJ | |
dc.contributor.author | Hollestelle, A | |
dc.contributor.author | van den Ouweland, AMW | |
dc.contributor.author | Jager, A | |
dc.contributor.author | Bui, QM | |
dc.contributor.author | Stone, J | |
dc.contributor.author | Dite, GS | |
dc.contributor.author | Apicella, C | |
dc.contributor.author | Tsimiklis, H | |
dc.contributor.author | Giles, GG | |
dc.contributor.author | Severi, G | |
dc.contributor.author | Baglietto, L | |
dc.contributor.author | Fasching, PA | |
dc.contributor.author | Haeberle, L | |
dc.contributor.author | Ekici, AB | |
dc.contributor.author | Beckmann, MW | |
dc.contributor.author | Brenner, H | |
dc.contributor.author | Müller, H | |
dc.contributor.author | Arndt, V | |
dc.contributor.author | Stegmaier, C | |
dc.contributor.author | Swerdlow, A | |
dc.contributor.author | Ashworth, A | |
dc.contributor.author | Orr, N | |
dc.contributor.author | Jones, M | |
dc.contributor.author | Figueroa, J | |
dc.contributor.author | Lissowska, J | |
dc.contributor.author | Brinton, L | |
dc.contributor.author | Goldberg, MS | |
dc.contributor.author | Labrèche, F | |
dc.contributor.author | Dumont, M | |
dc.contributor.author | Winqvist, R | |
dc.contributor.author | Pylkäs, K | |
dc.contributor.author | Jukkola-Vuorinen, A | |
dc.contributor.author | Grip, M | |
dc.contributor.author | Brauch, H | |
dc.contributor.author | Hamann, U | |
dc.contributor.author | Brüning, T | |
dc.contributor.author | GENICA (Gene Environment Interaction and Breast Cancer in Germany) Network, | |
dc.contributor.author | Radice, P | |
dc.contributor.author | Peterlongo, P | |
dc.contributor.author | Manoukian, S | |
dc.contributor.author | Bonanni, B | |
dc.contributor.author | Devilee, P | |
dc.contributor.author | Tollenaar, RAEM | |
dc.contributor.author | Seynaeve, C | |
dc.contributor.author | van Asperen, CJ | |
dc.contributor.author | Jakubowska, A | |
dc.contributor.author | Lubinski, J | |
dc.contributor.author | Jaworska, K | |
dc.contributor.author | Durda, K | |
dc.contributor.author | Mannermaa, A | |
dc.contributor.author | Kataja, V | |
dc.contributor.author | Kosma, V-M | |
dc.contributor.author | Hartikainen, JM | |
dc.contributor.author | Bogdanova, NV | |
dc.contributor.author | Antonenkova, NN | |
dc.contributor.author | Dörk, T | |
dc.contributor.author | Kristensen, VN | |
dc.contributor.author | Anton-Culver, H | |
dc.contributor.author | Slager, S | |
dc.contributor.author | Toland, AE | |
dc.contributor.author | Edge, S | |
dc.contributor.author | Fostira, F | |
dc.contributor.author | Kang, D | |
dc.contributor.author | Yoo, K-Y | |
dc.contributor.author | Noh, D-Y | |
dc.contributor.author | Matsuo, K | |
dc.contributor.author | Ito, H | |
dc.contributor.author | Iwata, H | |
dc.contributor.author | Sueta, A | |
dc.contributor.author | Wu, AH | |
dc.contributor.author | Tseng, C-C | |
dc.contributor.author | Van Den Berg, D | |
dc.contributor.author | Stram, DO | |
dc.contributor.author | Shu, X-O | |
dc.contributor.author | Lu, W | |
dc.contributor.author | Gao, Y-T | |
dc.contributor.author | Cai, H | |
dc.contributor.author | Teo, SH | |
dc.contributor.author | Yip, CH | |
dc.contributor.author | Phuah, SY | |
dc.contributor.author | Cornes, BK | |
dc.contributor.author | Hartman, M | |
dc.contributor.author | Miao, H | |
dc.contributor.author | Lim, WY | |
dc.contributor.author | Sng, J-H | |
dc.contributor.author | Muir, K | |
dc.contributor.author | Lophatananon, A | |
dc.contributor.author | Stewart-Brown, S | |
dc.contributor.author | Siriwanarangsan, P | |
dc.contributor.author | Shen, C-Y | |
dc.contributor.author | Hsiung, C-N | |
dc.contributor.author | Wu, P-E | |
dc.contributor.author | Ding, S-L | |
dc.contributor.author | Sangrajrang, S | |
dc.contributor.author | Gaborieau, V | |
dc.contributor.author | Brennan, P | |
dc.contributor.author | McKay, J | |
dc.contributor.author | Blot, WJ | |
dc.contributor.author | Signorello, LB | |
dc.contributor.author | Cai, Q | |
dc.contributor.author | Zheng, W | |
dc.contributor.author | Deming-Halverson, S | |
dc.contributor.author | Shrubsole, M | |
dc.contributor.author | Long, J | |
dc.contributor.author | Simard, J | |
dc.contributor.author | Garcia-Closas, M | |
dc.contributor.author | Pharoah, PDP | |
dc.contributor.author | Chenevix-Trench, G | |
dc.contributor.author | Dunning, AM | |
dc.contributor.author | Benitez, J | |
dc.contributor.author | Easton, DF | |
dc.date.accessioned | 2017-10-30T16:15:34Z | |
dc.date.issued | 2013-04-01 | |
dc.identifier.citation | Nature genetics, 2013, 45 (4), pp. 353 - 361e2 | |
dc.identifier.issn | 1061-4036 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/877 | |
dc.identifier.eissn | 1546-1718 | |
dc.identifier.doi | 10.1038/ng.2563 | |
dc.description.abstract | Breast cancer is the most common cancer among women. Common variants at 27 loci have been identified as associated with susceptibility to breast cancer, and these account for ∼9% of the familial risk of the disease. We report here a meta-analysis of 9 genome-wide association studies, including 10,052 breast cancer cases and 12,575 controls of European ancestry, from which we selected 29,807 SNPs for further genotyping. These SNPs were genotyped in 45,290 cases and 41,880 controls of European ancestry from 41 studies in the Breast Cancer Association Consortium (BCAC). The SNPs were genotyped as part of a collaborative genotyping experiment involving four consortia (Collaborative Oncological Gene-environment Study, COGS) and used a custom Illumina iSelect genotyping array, iCOGS, comprising more than 200,000 SNPs. We identified SNPs at 41 new breast cancer susceptibility loci at genome-wide significance (P < 5 × 10(-8)). Further analyses suggest that more than 1,000 additional loci are involved in breast cancer susceptibility. | |
dc.format | Print | |
dc.format.extent | 353 - 361e2 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | NATURE PUBLISHING GROUP | |
dc.rights.uri | https://www.rioxx.net/licenses/all-rights-reserved | |
dc.subject | Breast and Ovarian Cancer Susceptibility Collaboration | |
dc.subject | Hereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON) | |
dc.subject | kConFab Investigators | |
dc.subject | Australian Ovarian Cancer Study Group | |
dc.subject | GENICA (Gene Environment Interaction and Breast Cancer in Germany) Network | |
dc.subject | Humans | |
dc.subject | Breast Neoplasms | |
dc.subject | Genetic Predisposition to Disease | |
dc.subject | Risk Factors | |
dc.subject | Case-Control Studies | |
dc.subject | Cooperative Behavior | |
dc.subject | Genotype | |
dc.subject | Polymorphism, Single Nucleotide | |
dc.subject | Female | |
dc.subject | Meta-Analysis as Topic | |
dc.subject | Genome-Wide Association Study | |
dc.subject | Genetic Loci | |
dc.subject | Gene-Environment Interaction | |
dc.title | Large-scale genotyping identifies 41 new loci associated with breast cancer risk. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2013-01-30 | |
rioxxterms.versionofrecord | 10.1038/ng.2563 | |
rioxxterms.licenseref.uri | https://www.rioxx.net/licenses/all-rights-reserved | |
rioxxterms.licenseref.startdate | 2013-04 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | Nature genetics | |
pubs.issue | 4 | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Complex Trait Genetics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Functional Genetic Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Gene Function | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Genetic Susceptibility | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Closed research teams | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Closed research teams/Molecular Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Closed research teams/Predisposition & Translation Genetics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Genetic Susceptibility | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Gene Function | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Complex Trait Genetics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Functional Genetic Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Gene Function | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Genetic Susceptibility | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Closed research teams | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Closed research teams/Molecular Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Closed research teams/Predisposition & Translation Genetics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Genetic Susceptibility | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Gene Function | |
pubs.publication-status | Published | |
pubs.volume | 45 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Complex Trait Genetics | |
icr.researchteam | Functional Genetic Epidemiology | |
icr.researchteam | Molecular Epidemiology | |
icr.researchteam | Predisposition & Translation Genetics | |
icr.researchteam | Aetiological Epidemiology | |
icr.researchteam | Genetic Susceptibility | |
icr.researchteam | Gene Function | |
dc.contributor.icrauthor | Turnbull, Clare | |
dc.contributor.icrauthor | Fletcher, Olivia | |
dc.contributor.icrauthor | Swerdlow, Anthony | |
dc.contributor.icrauthor | Jones, Michael | |
dc.contributor.icrauthor | Garcia-Closas, Montserrat | |