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dc.contributor.authorMichailidou, Ken_US
dc.contributor.authorHall, Pen_US
dc.contributor.authorGonzalez-Neira, Aen_US
dc.contributor.authorGhoussaini, Men_US
dc.contributor.authorDennis, Jen_US
dc.contributor.authorMilne, RLen_US
dc.contributor.authorSchmidt, MKen_US
dc.contributor.authorChang-Claude, Jen_US
dc.contributor.authorBojesen, SEen_US
dc.contributor.authorBolla, MKen_US
dc.contributor.authorWang, Qen_US
dc.contributor.authorDicks, Een_US
dc.contributor.authorLee, Aen_US
dc.contributor.authorTurnbull, Cen_US
dc.contributor.authorRahman, Nen_US
dc.contributor.authorFletcher, Oen_US
dc.contributor.authorPeto, Jen_US
dc.contributor.authorGibson, Len_US
dc.contributor.authorDos Santos Silva, Ien_US
dc.contributor.authorNevanlinna, Hen_US
dc.contributor.authorMuranen, TAen_US
dc.contributor.authorAittomäki, Ken_US
dc.contributor.authorBlomqvist, Cen_US
dc.contributor.authorCzene, Ken_US
dc.contributor.authorIrwanto, Aen_US
dc.contributor.authorLiu, Jen_US
dc.contributor.authorWaisfisz, Qen_US
dc.contributor.authorMeijers-Heijboer, Hen_US
dc.contributor.authorAdank, Men_US
dc.contributor.authorvan der Luijt, RBen_US
dc.contributor.authorHein, Ren_US
dc.contributor.authorDahmen, Nen_US
dc.contributor.authorBeckman, Len_US
dc.contributor.authorMeindl, Aen_US
dc.contributor.authorSchmutzler, RKen_US
dc.contributor.authorMüller-Myhsok, Ben_US
dc.contributor.authorLichtner, Pen_US
dc.contributor.authorHopper, JLen_US
dc.contributor.authorSouthey, MCen_US
dc.contributor.authorMakalic, Een_US
dc.contributor.authorSchmidt, DFen_US
dc.contributor.authorUitterlinden, AGen_US
dc.contributor.authorHofman, Aen_US
dc.contributor.authorHunter, DJen_US
dc.contributor.authorChanock, SJen_US
dc.contributor.authorVincent, Den_US
dc.contributor.authorBacot, Fen_US
dc.contributor.authorTessier, DCen_US
dc.contributor.authorCanisius, Sen_US
dc.contributor.authorWessels, LFen_US
dc.contributor.authorHaiman, CAen_US
dc.contributor.authorShah, Men_US
dc.contributor.authorLuben, Ren_US
dc.contributor.authorBrown, Jen_US
dc.contributor.authorLuccarini, Cen_US
dc.contributor.authorSchoof, Nen_US
dc.contributor.authorHumphreys, Ken_US
dc.contributor.authorLi, Jen_US
dc.contributor.authorNordestgaard, BGen_US
dc.contributor.authorNielsen, SFen_US
dc.contributor.authorFlyger, Hen_US
dc.contributor.authorCouch, FJen_US
dc.contributor.authorWang, Xen_US
dc.contributor.authorVachon, Cen_US
dc.contributor.authorStevens, KNen_US
dc.contributor.authorLambrechts, Den_US
dc.contributor.authorMoisse, Men_US
dc.contributor.authorParidaens, Ren_US
dc.contributor.authorChristiaens, MRen_US
dc.contributor.authorRudolph, Aen_US
dc.contributor.authorNickels, Sen_US
dc.contributor.authorFlesch-Janys, Den_US
dc.contributor.authorJohnson, Nen_US
dc.contributor.authorAitken, Zen_US
dc.contributor.authorAaltonen, Ken_US
dc.contributor.authorHeikkinen, Ten_US
dc.contributor.authorBroeks, Aen_US
dc.contributor.authorVeer, LJen_US
dc.contributor.authorvan der Schoot, CEen_US
dc.contributor.authorGuénel, Pen_US
dc.contributor.authorTruong, Ten_US
dc.contributor.authorLaurent-Puig, Pen_US
dc.contributor.authorMenegaux, Fen_US
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dc.contributor.authorSchneeweiss, Aen_US
dc.contributor.authorSohn, Cen_US
dc.contributor.authorBurwinkel, Ben_US
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dc.contributor.authorPerez, JIen_US
dc.contributor.authorPita, Gen_US
dc.contributor.authorAlonso, MRen_US
dc.contributor.authorCox, Aen_US
dc.contributor.authorBrock, IWen_US
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dc.contributor.authorReed, MWen_US
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dc.contributor.authorKerin, MJen_US
dc.contributor.authorMiller, Nen_US
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dc.contributor.authorLe Marchand, Len_US
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dc.contributor.authorGlendon, Gen_US
dc.contributor.authorMulligan, AMen_US
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dc.contributor.authorMargolin, Sen_US
dc.contributor.authorHooning, MJen_US
dc.contributor.authorHollestelle, Aen_US
dc.contributor.authorvan den Ouweland, AMen_US
dc.contributor.authorJager, Aen_US
dc.contributor.authorBui, QMen_US
dc.contributor.authorStone, Jen_US
dc.contributor.authorDite, GSen_US
dc.contributor.authorApicella, Cen_US
dc.contributor.authorTsimiklis, Hen_US
dc.contributor.authorGiles, GGen_US
dc.contributor.authorSeveri, Gen_US
dc.contributor.authorBaglietto, Len_US
dc.contributor.authorFasching, PAen_US
dc.contributor.authorHaeberle, Len_US
dc.contributor.authorEkici, ABen_US
dc.contributor.authorBeckmann, MWen_US
dc.contributor.authorBrenner, Hen_US
dc.contributor.authorMüller, Hen_US
dc.contributor.authorArndt, Ven_US
dc.contributor.authorStegmaier, Cen_US
dc.contributor.authorSwerdlow, Aen_US
dc.contributor.authorAshworth, Aen_US
dc.contributor.authorOrr, Nen_US
dc.contributor.authorJones, Men_US
dc.contributor.authorFigueroa, Jen_US
dc.contributor.authorLissowska, Jen_US
dc.contributor.authorBrinton, Len_US
dc.contributor.authorGoldberg, MSen_US
dc.contributor.authorLabrèche, Fen_US
dc.contributor.authorDumont, Men_US
dc.contributor.authorWinqvist, Ren_US
dc.contributor.authorPylkäs, Ken_US
dc.contributor.authorJukkola-Vuorinen, Aen_US
dc.contributor.authorGrip, Men_US
dc.contributor.authorBrauch, Hen_US
dc.contributor.authorHamann, Uen_US
dc.contributor.authorBrüning, Ten_US
dc.contributor.authorRadice, Pen_US
dc.contributor.authorPeterlongo, Pen_US
dc.contributor.authorManoukian, Sen_US
dc.contributor.authorBonanni, Ben_US
dc.contributor.authorDevilee, Pen_US
dc.contributor.authorTollenaar, RAen_US
dc.contributor.authorSeynaeve, Cen_US
dc.contributor.authorvan Asperen, CJen_US
dc.contributor.authorJakubowska, Aen_US
dc.contributor.authorLubinski, Jen_US
dc.contributor.authorJaworska, Ken_US
dc.contributor.authorDurda, Ken_US
dc.contributor.authorMannermaa, Aen_US
dc.contributor.authorKataja, Ven_US
dc.contributor.authorKosma, VMen_US
dc.contributor.authorHartikainen, JMen_US
dc.contributor.authorBogdanova, NVen_US
dc.contributor.authorAntonenkova, NNen_US
dc.contributor.authorDörk, Ten_US
dc.contributor.authorKristensen, VNen_US
dc.contributor.authorAnton-Culver, Hen_US
dc.contributor.authorSlager, Sen_US
dc.contributor.authorToland, AEen_US
dc.contributor.authorEdge, Sen_US
dc.contributor.authorFostira, Fen_US
dc.contributor.authorKang, Den_US
dc.contributor.authorYoo, KYen_US
dc.contributor.authorNoh, DYen_US
dc.contributor.authorMatsuo, Ken_US
dc.contributor.authorIto, Hen_US
dc.contributor.authorIwata, Hen_US
dc.contributor.authorSueta, Aen_US
dc.contributor.authorWu, AHen_US
dc.contributor.authorTseng, CCen_US
dc.contributor.authorVan Den Berg, Den_US
dc.contributor.authorStram, DOen_US
dc.contributor.authorShu, XOen_US
dc.contributor.authorLu, Wen_US
dc.contributor.authorGao, YTen_US
dc.contributor.authorCai, Hen_US
dc.contributor.authorTeo, SHen_US
dc.contributor.authorYip, CHen_US
dc.contributor.authorPhuah, SYen_US
dc.contributor.authorCornes, BKen_US
dc.contributor.authorHartman, Men_US
dc.contributor.authorMiao, Hen_US
dc.contributor.authorLim, WYen_US
dc.contributor.authorSng, JHen_US
dc.contributor.authorMuir, Ken_US
dc.contributor.authorLophatananon, Aen_US
dc.contributor.authorStewart-Brown, Sen_US
dc.contributor.authorSiriwanarangsan, Pen_US
dc.contributor.authorShen, CYen_US
dc.contributor.authorHsiung, CNen_US
dc.contributor.authorWu, PEen_US
dc.contributor.authorDing, SLen_US
dc.contributor.authorSangrajrang, Sen_US
dc.contributor.authorGaborieau, Ven_US
dc.contributor.authorBrennan, Pen_US
dc.contributor.authorMcKay, Jen_US
dc.contributor.authorBlot, WJen_US
dc.contributor.authorSignorello, LBen_US
dc.contributor.authorCai, Qen_US
dc.contributor.authorZheng, Wen_US
dc.contributor.authorDeming-Halverson, Sen_US
dc.contributor.authorShrubsole, Men_US
dc.contributor.authorLong, Jen_US
dc.contributor.authorSimard, Jen_US
dc.contributor.authorGarcia-Closas, Men_US
dc.contributor.authorPharoah, PDen_US
dc.contributor.authorChenevix-Trench, Gen_US
dc.contributor.authorDunning, AMen_US
dc.contributor.authorBenitez, Jen_US
dc.contributor.authorEaston, DFen_US
dc.date.accessioned2017-10-30T16:15:34Z
dc.date.issued2013-04en_US
dc.identifier.citationNature genetics, 2013, 45 (4), pp. 353 - 361e2en_US
dc.identifier.issn1061-4036en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/877
dc.identifier.eissn1546-1718en_US
dc.identifier.doi10.1038/ng.2563en_US
dc.description.abstractBreast cancer is the most common cancer among women. Common variants at 27 loci have been identified as associated with susceptibility to breast cancer, and these account for ∼9% of the familial risk of the disease. We report here a meta-analysis of 9 genome-wide association studies, including 10,052 breast cancer cases and 12,575 controls of European ancestry, from which we selected 29,807 SNPs for further genotyping. These SNPs were genotyped in 45,290 cases and 41,880 controls of European ancestry from 41 studies in the Breast Cancer Association Consortium (BCAC). The SNPs were genotyped as part of a collaborative genotyping experiment involving four consortia (Collaborative Oncological Gene-environment Study, COGS) and used a custom Illumina iSelect genotyping array, iCOGS, comprising more than 200,000 SNPs. We identified SNPs at 41 new breast cancer susceptibility loci at genome-wide significance (P < 5 × 10(-8)). Further analyses suggest that more than 1,000 additional loci are involved in breast cancer susceptibility.en_US
dc.formatPrinten_US
dc.format.extent353 - 361e2en_US
dc.languageengen_US
dc.language.isoengen_US
dc.rights.urihttp://www.rioxx.net/licenses/all-rights-reserveden_US
dc.subjectBreast and Ovarian Cancer Susceptibility Collaborationen_US
dc.subjectHereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON)en_US
dc.subjectkConFab Investigatorsen_US
dc.subjectAustralian Ovarian Cancer Study Groupen_US
dc.subjectGENICA (Gene Environment Interaction and Breast Cancer in Germany) Networken_US
dc.subjectHumansen_US
dc.subjectBreast Neoplasmsen_US
dc.subjectGenetic Predisposition to Diseaseen_US
dc.subjectRisk Factorsen_US
dc.subjectCase-Control Studiesen_US
dc.subjectCooperative Behavioren_US
dc.subjectGenotypeen_US
dc.subjectPolymorphism, Single Nucleotideen_US
dc.subjectFemaleen_US
dc.subjectMeta-Analysis as Topicen_US
dc.subjectGenome-Wide Association Studyen_US
dc.subjectGenetic Locien_US
dc.subjectGene-Environment Interactionen_US
dc.titleLarge-scale genotyping identifies 41 new loci associated with breast cancer risk.en_US
dc.typeJournal Article
dcterms.dateAccepted2013-01-30en_US
rioxxterms.versionofrecord10.1038/ng.2563en_US
rioxxterms.licenseref.startdate2013-04en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfNature geneticsen_US
pubs.issue4en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Complex Trait Genetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Functional Genetic Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Gene Function
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Genetic Susceptibility
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams/Molecular Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams/Predisposition & Translation Genetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Genetic Susceptibility
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Molecular & Population Genetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Gene Function
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Molecular & Population Genetics
pubs.volume45en_US
pubs.embargo.termsNot knownen_US
icr.researchteamComplex Trait Geneticsen_US
icr.researchteamFunctional Genetic Epidemiologyen_US
icr.researchteamMolecular Epidemiologyen_US
icr.researchteamPredisposition & Translation Geneticsen_US
icr.researchteamAetiological Epidemiologyen_US
icr.researchteamGenetic Susceptibilityen_US
icr.researchteamGene Functionen_US
icr.researchteamMolecular & Population Geneticsen_US
dc.contributor.icrauthorAshworth, Alanen_US
dc.contributor.icrauthorJones, Michaelen_US
dc.contributor.icrauthorRahman, Saberaen_US
dc.contributor.icrauthorFletcher, Oliviaen_US
dc.contributor.icrauthorOrr, Nicholasen_US
dc.contributor.icrauthorGarcia-Closas, Montserraten_US
dc.contributor.icrauthorTurnbull, Clare Annen_US
dc.contributor.icrauthorTurnbull, Clareen_US
dc.contributor.icrauthorSwerdlow, Anthonyen_US


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