Show simple item record

dc.contributor.authorMichailidou, K
dc.contributor.authorHall, P
dc.contributor.authorGonzalez-Neira, A
dc.contributor.authorGhoussaini, M
dc.contributor.authorDennis, J
dc.contributor.authorMilne, RL
dc.contributor.authorSchmidt, MK
dc.contributor.authorChang-Claude, J
dc.contributor.authorBojesen, SE
dc.contributor.authorBolla, MK
dc.contributor.authorWang, Q
dc.contributor.authorDicks, E
dc.contributor.authorLee, A
dc.contributor.authorTurnbull, C
dc.contributor.authorRahman, N
dc.contributor.authorBreast and Ovarian Cancer Susceptibility Collaboration
dc.contributor.authorFletcher, O
dc.contributor.authorPeto, J
dc.contributor.authorGibson, L
dc.contributor.authorDos Santos Silva, I
dc.contributor.authorNevanlinna, H
dc.contributor.authorMuranen, TA
dc.contributor.authorAittomäki, K
dc.contributor.authorBlomqvist, C
dc.contributor.authorCzene, K
dc.contributor.authorIrwanto, A
dc.contributor.authorLiu, J
dc.contributor.authorWaisfisz, Q
dc.contributor.authorMeijers-Heijboer, H
dc.contributor.authorAdank, M
dc.contributor.authorHereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON)
dc.contributor.authorvan der Luijt, RB
dc.contributor.authorHein, R
dc.contributor.authorDahmen, N
dc.contributor.authorBeckman, L
dc.contributor.authorMeindl, A
dc.contributor.authorSchmutzler, RK
dc.contributor.authorMüller-Myhsok, B
dc.contributor.authorLichtner, P
dc.contributor.authorHopper, JL
dc.contributor.authorSouthey, MC
dc.contributor.authorMakalic, E
dc.contributor.authorSchmidt, DF
dc.contributor.authorUitterlinden, AG
dc.contributor.authorHofman, A
dc.contributor.authorHunter, DJ
dc.contributor.authorChanock, SJ
dc.contributor.authorVincent, D
dc.contributor.authorBacot, F
dc.contributor.authorTessier, DC
dc.contributor.authorCanisius, S
dc.contributor.authorWessels, LFA
dc.contributor.authorHaiman, CA
dc.contributor.authorShah, M
dc.contributor.authorLuben, R
dc.contributor.authorBrown, J
dc.contributor.authorLuccarini, C
dc.contributor.authorSchoof, N
dc.contributor.authorHumphreys, K
dc.contributor.authorLi, J
dc.contributor.authorNordestgaard, BG
dc.contributor.authorNielsen, SF
dc.contributor.authorFlyger, H
dc.contributor.authorCouch, FJ
dc.contributor.authorWang, X
dc.contributor.authorVachon, C
dc.contributor.authorStevens, KN
dc.contributor.authorLambrechts, D
dc.contributor.authorMoisse, M
dc.contributor.authorParidaens, R
dc.contributor.authorChristiaens, M-R
dc.contributor.authorRudolph, A
dc.contributor.authorNickels, S
dc.contributor.authorFlesch-Janys, D
dc.contributor.authorJohnson, N
dc.contributor.authorAitken, Z
dc.contributor.authorAaltonen, K
dc.contributor.authorHeikkinen, T
dc.contributor.authorBroeks, A
dc.contributor.authorVeer, LJV
dc.contributor.authorvan der Schoot, CE
dc.contributor.authorGuénel, P
dc.contributor.authorTruong, T
dc.contributor.authorLaurent-Puig, P
dc.contributor.authorMenegaux, F
dc.contributor.authorMarme, F
dc.contributor.authorSchneeweiss, A
dc.contributor.authorSohn, C
dc.contributor.authorBurwinkel, B
dc.contributor.authorZamora, MP
dc.contributor.authorPerez, JIA
dc.contributor.authorPita, G
dc.contributor.authorAlonso, MR
dc.contributor.authorCox, A
dc.contributor.authorBrock, IW
dc.contributor.authorCross, SS
dc.contributor.authorReed, MWR
dc.contributor.authorSawyer, EJ
dc.contributor.authorTomlinson, I
dc.contributor.authorKerin, MJ
dc.contributor.authorMiller, N
dc.contributor.authorHenderson, BE
dc.contributor.authorSchumacher, F
dc.contributor.authorLe Marchand, L
dc.contributor.authorAndrulis, IL
dc.contributor.authorKnight, JA
dc.contributor.authorGlendon, G
dc.contributor.authorMulligan, AM
dc.contributor.authorkConFab Investigators
dc.contributor.authorAustralian Ovarian Cancer Study Group
dc.contributor.authorLindblom, A
dc.contributor.authorMargolin, S
dc.contributor.authorHooning, MJ
dc.contributor.authorHollestelle, A
dc.contributor.authorvan den Ouweland, AMW
dc.contributor.authorJager, A
dc.contributor.authorBui, QM
dc.contributor.authorStone, J
dc.contributor.authorDite, GS
dc.contributor.authorApicella, C
dc.contributor.authorTsimiklis, H
dc.contributor.authorGiles, GG
dc.contributor.authorSeveri, G
dc.contributor.authorBaglietto, L
dc.contributor.authorFasching, PA
dc.contributor.authorHaeberle, L
dc.contributor.authorEkici, AB
dc.contributor.authorBeckmann, MW
dc.contributor.authorBrenner, H
dc.contributor.authorMüller, H
dc.contributor.authorArndt, V
dc.contributor.authorStegmaier, C
dc.contributor.authorSwerdlow, A
dc.contributor.authorAshworth, A
dc.contributor.authorOrr, N
dc.contributor.authorJones, M
dc.contributor.authorFigueroa, J
dc.contributor.authorLissowska, J
dc.contributor.authorBrinton, L
dc.contributor.authorGoldberg, MS
dc.contributor.authorLabrèche, F
dc.contributor.authorDumont, M
dc.contributor.authorWinqvist, R
dc.contributor.authorPylkäs, K
dc.contributor.authorJukkola-Vuorinen, A
dc.contributor.authorGrip, M
dc.contributor.authorBrauch, H
dc.contributor.authorHamann, U
dc.contributor.authorBrüning, T
dc.contributor.authorGENICA (Gene Environment Interaction and Breast Cancer in Germany) Network
dc.contributor.authorRadice, P
dc.contributor.authorPeterlongo, P
dc.contributor.authorManoukian, S
dc.contributor.authorBonanni, B
dc.contributor.authorDevilee, P
dc.contributor.authorTollenaar, RAEM
dc.contributor.authorSeynaeve, C
dc.contributor.authorvan Asperen, CJ
dc.contributor.authorJakubowska, A
dc.contributor.authorLubinski, J
dc.contributor.authorJaworska, K
dc.contributor.authorDurda, K
dc.contributor.authorMannermaa, A
dc.contributor.authorKataja, V
dc.contributor.authorKosma, V-M
dc.contributor.authorHartikainen, JM
dc.contributor.authorBogdanova, NV
dc.contributor.authorAntonenkova, NN
dc.contributor.authorDörk, T
dc.contributor.authorKristensen, VN
dc.contributor.authorAnton-Culver, H
dc.contributor.authorSlager, S
dc.contributor.authorToland, AE
dc.contributor.authorEdge, S
dc.contributor.authorFostira, F
dc.contributor.authorKang, D
dc.contributor.authorYoo, K-Y
dc.contributor.authorNoh, D-Y
dc.contributor.authorMatsuo, K
dc.contributor.authorIto, H
dc.contributor.authorIwata, H
dc.contributor.authorSueta, A
dc.contributor.authorWu, AH
dc.contributor.authorTseng, C-C
dc.contributor.authorVan Den Berg, D
dc.contributor.authorStram, DO
dc.contributor.authorShu, X-O
dc.contributor.authorLu, W
dc.contributor.authorGao, Y-T
dc.contributor.authorCai, H
dc.contributor.authorTeo, SH
dc.contributor.authorYip, CH
dc.contributor.authorPhuah, SY
dc.contributor.authorCornes, BK
dc.contributor.authorHartman, M
dc.contributor.authorMiao, H
dc.contributor.authorLim, WY
dc.contributor.authorSng, J-H
dc.contributor.authorMuir, K
dc.contributor.authorLophatananon, A
dc.contributor.authorStewart-Brown, S
dc.contributor.authorSiriwanarangsan, P
dc.contributor.authorShen, C-Y
dc.contributor.authorHsiung, C-N
dc.contributor.authorWu, P-E
dc.contributor.authorDing, S-L
dc.contributor.authorSangrajrang, S
dc.contributor.authorGaborieau, V
dc.contributor.authorBrennan, P
dc.contributor.authorMcKay, J
dc.contributor.authorBlot, WJ
dc.contributor.authorSignorello, LB
dc.contributor.authorCai, Q
dc.contributor.authorZheng, W
dc.contributor.authorDeming-Halverson, S
dc.contributor.authorShrubsole, M
dc.contributor.authorLong, J
dc.contributor.authorSimard, J
dc.contributor.authorGarcia-Closas, M
dc.contributor.authorPharoah, PDP
dc.contributor.authorChenevix-Trench, G
dc.contributor.authorDunning, AM
dc.contributor.authorBenitez, J
dc.contributor.authorEaston, DF
dc.date.accessioned2017-10-30T16:15:34Z
dc.date.issued2013-04
dc.identifier.citationNature genetics, 2013, 45 (4), pp. 353 - 361e2
dc.identifier.issn1061-4036
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/877
dc.identifier.eissn1546-1718
dc.identifier.doi10.1038/ng.2563
dc.description.abstractBreast cancer is the most common cancer among women. Common variants at 27 loci have been identified as associated with susceptibility to breast cancer, and these account for ∼9% of the familial risk of the disease. We report here a meta-analysis of 9 genome-wide association studies, including 10,052 breast cancer cases and 12,575 controls of European ancestry, from which we selected 29,807 SNPs for further genotyping. These SNPs were genotyped in 45,290 cases and 41,880 controls of European ancestry from 41 studies in the Breast Cancer Association Consortium (BCAC). The SNPs were genotyped as part of a collaborative genotyping experiment involving four consortia (Collaborative Oncological Gene-environment Study, COGS) and used a custom Illumina iSelect genotyping array, iCOGS, comprising more than 200,000 SNPs. We identified SNPs at 41 new breast cancer susceptibility loci at genome-wide significance (P < 5 × 10(-8)). Further analyses suggest that more than 1,000 additional loci are involved in breast cancer susceptibility.
dc.formatPrint
dc.format.extent353 - 361e2
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://www.rioxx.net/licenses/all-rights-reserved
dc.subjectBreast and Ovarian Cancer Susceptibility Collaboration
dc.subjectHereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON)
dc.subjectkConFab Investigators
dc.subjectAustralian Ovarian Cancer Study Group
dc.subjectGENICA (Gene Environment Interaction and Breast Cancer in Germany) Network
dc.subjectHumans
dc.subjectBreast Neoplasms
dc.subjectGenetic Predisposition to Disease
dc.subjectRisk Factors
dc.subjectCase-Control Studies
dc.subjectCooperative Behavior
dc.subjectGenotype
dc.subjectPolymorphism, Single Nucleotide
dc.subjectFemale
dc.subjectMeta-Analysis as Topic
dc.subjectGenome-Wide Association Study
dc.subjectGenetic Loci
dc.subjectGene-Environment Interaction
dc.titleLarge-scale genotyping identifies 41 new loci associated with breast cancer risk.
dc.typeJournal Article
dcterms.dateAccepted2013-01-30
rioxxterms.versionofrecord10.1038/ng.2563
rioxxterms.licenseref.urihttps://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2013-04
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfNature genetics
pubs.issue4
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Complex Trait Genetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Functional Genetic Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Gene Function
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Genetic Susceptibility
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams/Molecular Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams/Predisposition & Translation Genetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Genetic Susceptibility
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Gene Function
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Complex Trait Genetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Functional Genetic Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Gene Function
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Genetic Susceptibility
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams/Molecular Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams/Predisposition & Translation Genetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Genetic Susceptibility
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Gene Function
pubs.publication-statusPublished
pubs.volume45
pubs.embargo.termsNot known
icr.researchteamComplex Trait Geneticsen_US
icr.researchteamFunctional Genetic Epidemiologyen_US
icr.researchteamMolecular Epidemiologyen_US
icr.researchteamPredisposition & Translation Geneticsen_US
icr.researchteamAetiological Epidemiologyen_US
icr.researchteamGenetic Susceptibilityen_US
icr.researchteamGene Functionen_US
dc.contributor.icrauthorFletcher, Oliviaen
dc.contributor.icrauthorGarcia-Closas, Montserraten
dc.contributor.icrauthorTurnbull, Clare Annen
dc.contributor.icrauthorAshworth, Alanen
dc.contributor.icrauthorJones, Michaelen
dc.contributor.icrauthorRahman, Saberaen
dc.contributor.icrauthorOrr, Nicholasen
dc.contributor.icrauthorTurnbull, Clareen
dc.contributor.icrauthorSwerdlow, Anthonyen


Files in this item

Thumbnail

This item appears in the following collection(s)

Show simple item record