Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study.
Date
2017-05-01Author
Telomeres Mendelian Randomization Collaboration,
Haycock, PC
Burgess, S
Nounu, A
Zheng, J
Okoli, GN
Bowden, J
Wade, KH
Timpson, NJ
Evans, DM
Willeit, P
Aviv, A
Gaunt, TR
Hemani, G
Mangino, M
Ellis, HP
Kurian, KM
Pooley, KA
Eeles, RA
Lee, JE
Fang, S
Chen, WV
Law, MH
Bowdler, LM
Iles, MM
Yang, Q
Worrall, BB
Markus, HS
Hung, RJ
Amos, CI
Spurdle, AB
Thompson, DJ
O'Mara, TA
Wolpin, B
Amundadottir, L
Stolzenberg-Solomon, R
Trichopoulou, A
Onland-Moret, NC
Lund, E
Duell, EJ
Canzian, F
Severi, G
Overvad, K
Gunter, MJ
Tumino, R
Svenson, U
van Rij, A
Baas, AF
Bown, MJ
Samani, NJ
van t'Hof, FNG
Tromp, G
Jones, GT
Kuivaniemi, H
Elmore, JR
Johansson, M
Mckay, J
Scelo, G
Carreras-Torres, R
Gaborieau, V
Brennan, P
Bracci, PM
Neale, RE
Olson, SH
Gallinger, S
Li, D
Petersen, GM
Risch, HA
Klein, AP
Han, J
Abnet, CC
Freedman, ND
Taylor, PR
Maris, JM
Aben, KK
Kiemeney, LA
Vermeulen, SH
Wiencke, JK
Walsh, KM
Wrensch, M
Rice, T
Turnbull, C
Litchfield, K
Paternoster, L
Standl, M
Abecasis, GR
SanGiovanni, JP
Li, Y
Mijatovic, V
Sapkota, Y
Low, S-K
Zondervan, KT
Montgomery, GW
Nyholt, DR
van Heel, DA
Hunt, K
Arking, DE
Ashar, FN
Sotoodehnia, N
Woo, D
Rosand, J
Comeau, ME
Brown, WM
Silverman, EK
Hokanson, JE
Cho, MH
Hui, J
Ferreira, MA
Thompson, PJ
Morrison, AC
Felix, JF
Smith, NL
Christiano, AM
Petukhova, L
Betz, RC
Fan, X
Zhang, X
Zhu, C
Langefeld, CD
Thompson, SD
Wang, F
Lin, X
Schwartz, DA
Fingerlin, T
Rotter, JI
Cotch, MF
Jensen, RA
Munz, M
Dommisch, H
Schaefer, AS
Han, F
Ollila, HM
Hillary, RP
Albagha, O
Ralston, SH
Zeng, C
Zheng, W
Shu, X-O
Reis, A
Uebe, S
Hüffmeier, U
Kawamura, Y
Otowa, T
Sasaki, T
Hibberd, ML
Davila, S
Xie, G
Siminovitch, K
Bei, J-X
Zeng, Y-X
Försti, A
Chen, B
Landi, S
Franke, A
Fischer, A
Ellinghaus, D
Flores, C
Noth, I
Ma, S-F
Foo, JN
Liu, J
Kim, J-W
Cox, DG
Delattre, O
Mirabeau, O
Skibola, CF
Tang, CS
Garcia-Barcelo, M
Chang, K-P
Su, W-H
Chang, Y-S
Martin, NG
Gordon, S
Wade, TD
Lee, C
Kubo, M
Cha, P-C
Nakamura, Y
Levy, D
Kimura, M
Hwang, S-J
Hunt, S
Spector, T
Soranzo, N
Manichaikul, AW
Barr, RG
Kahali, B
Speliotes, E
Yerges-Armstrong, LM
Cheng, C-Y
Jonas, JB
Wong, TY
Fogh, I
Lin, K
Powell, JF
Rice, K
Relton, CL
Martin, RM
Davey Smith, G
Type
Journal Article
Metadata
Show full item recordAbstract
IMPORTANCE: The causal direction and magnitude of the association between telomere length and incidence of cancer and non-neoplastic diseases is uncertain owing to the susceptibility of observational studies to confounding and reverse causation. OBJECTIVE: To conduct a Mendelian randomization study, using germline genetic variants as instrumental variables, to appraise the causal relevance of telomere length for risk of cancer and non-neoplastic diseases. DATA SOURCES: Genomewide association studies (GWAS) published up to January 15, 2015. STUDY SELECTION: GWAS of noncommunicable diseases that assayed germline genetic variation and did not select cohort or control participants on the basis of preexisting diseases. Of 163 GWAS of noncommunicable diseases identified, summary data from 103 were available. DATA EXTRACTION AND SYNTHESIS: Summary association statistics for single nucleotide polymorphisms (SNPs) that are strongly associated with telomere length in the general population. MAIN OUTCOMES AND MEASURES: Odds ratios (ORs) and 95% confidence intervals (CIs) for disease per standard deviation (SD) higher telomere length due to germline genetic variation. RESULTS: Summary data were available for 35 cancers and 48 non-neoplastic diseases, corresponding to 420 081 cases (median cases, 2526 per disease) and 1 093 105 controls (median, 6789 per disease). Increased telomere length due to germline genetic variation was generally associated with increased risk for site-specific cancers. The strongest associations (ORs [95% CIs] per 1-SD change in genetically increased telomere length) were observed for glioma, 5.27 (3.15-8.81); serous low-malignant-potential ovarian cancer, 4.35 (2.39-7.94); lung adenocarcinoma, 3.19 (2.40-4.22); neuroblastoma, 2.98 (1.92-4.62); bladder cancer, 2.19 (1.32-3.66); melanoma, 1.87 (1.55-2.26); testicular cancer, 1.76 (1.02-3.04); kidney cancer, 1.55 (1.08-2.23); and endometrial cancer, 1.31 (1.07-1.61). Associations were stronger for rarer cancers and at tissue sites with lower rates of stem cell division. There was generally little evidence of association between genetically increased telomere length and risk of psychiatric, autoimmune, inflammatory, diabetic, and other non-neoplastic diseases, except for coronary heart disease (OR, 0.78 [95% CI, 0.67-0.90]), abdominal aortic aneurysm (OR, 0.63 [95% CI, 0.49-0.81]), celiac disease (OR, 0.42 [95% CI, 0.28-0.61]) and interstitial lung disease (OR, 0.09 [95% CI, 0.05-0.15]). CONCLUSIONS AND RELEVANCE: It is likely that longer telomeres increase risk for several cancers but reduce risk for some non-neoplastic diseases, including cardiovascular diseases.
Subject
Telomeres Mendelian Randomization Collaboration
Telomere
Humans
Neoplasms
Cardiovascular Diseases
Genetic Predisposition to Disease
Risk Assessment
Germ-Line Mutation
Polymorphism, Single Nucleotide
Adult
Aged
Aged, 80 and over
Middle Aged
Female
Male
Genome-Wide Association Study
Mendelian Randomization Analysis
Telomere Homeostasis
Research team
Molecular & Population Genetics
Oncogenetics
Language
eng
Date accepted
2016-10-21
License start date
2017-05
Citation
JAMA oncology, 2017, 3 (5), pp. 636 - 651
Publisher
AMER MEDICAL ASSOC
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