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MIR21 Drives Resistance to Heat Shock Protein 90 Inhibition in Cholangiocarcinoma.
BACKGROUND & AIMS:Cholangiocarcinomas (CCA) are resistant to chemotherapy, so new therapeutic agents are needed. We performed a screen to identify small-molecule compounds that are active against CCAs. Levels of microRNA ...
Patient-derived organoids model treatment response of metastatic gastrointestinal cancers.
Patient-derived organoids (PDOs) have recently emerged as robust preclinical models; however, their potential to predict clinical outcomes in patients has remained unclear. We report on a living biobank of PDOs from ...