dc.contributor.author | Mansur, MB | |
dc.contributor.author | Ford, AM | |
dc.contributor.author | Emerenciano, M | |
dc.date.accessioned | 2017-11-24T15:37:00Z | |
dc.date.issued | 2017-12-01 | |
dc.identifier.citation | Biochimica et biophysica acta. Reviews on cancer, 2017, 1868 (2), pp. 521 - 526 | |
dc.identifier.issn | 0304-419X | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/952 | |
dc.identifier.eissn | 1879-2561 | |
dc.identifier.doi | 10.1016/j.bbcan.2017.10.005 | |
dc.description.abstract | Childhood acute lymphoblastic leukaemia (ALL) with MLL rearrangement (MLL-r) is an aggressive disease still associated with a high mortality rate. Recent investigations have identified co-operating mutations in the RAS pathway and although the functional consequences of these mutations are not yet fully understood, aberrant regulation of RAS pathway signalling at both transcriptional and protein levels is observed. Studies investigating the efficacy of specific inhibitors of this pathway, e.g. MEK-inhibitors, have also achieved encouraging results. In this context, this mini-review summarizes the available data surrounding MLL-r infant ALL with RAS mutation in relation to other well-known features of this intriguing disease. | |
dc.format | Print-Electronic | |
dc.format.extent | 521 - 526 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | ELSEVIER | |
dc.rights.uri | https://www.rioxx.net/licenses/under-embargo-all-rights-reserved | |
dc.subject | Humans | |
dc.subject | Histone-Lysine N-Methyltransferase | |
dc.subject | Mitogen-Activated Protein Kinase Kinases | |
dc.subject | Gene Rearrangement | |
dc.subject | Mutation | |
dc.subject | Genes, ras | |
dc.subject | Myeloid-Lymphoid Leukemia Protein | |
dc.subject | fms-Like Tyrosine Kinase 3 | |
dc.subject | Precursor Cell Lymphoblastic Leukemia-Lymphoma | |
dc.title | The role of RAS mutations in MLL-rearranged leukaemia: A path to intervention? | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2017-10-18 | |
rioxxterms.versionofrecord | 10.1016/j.bbcan.2017.10.005 | |
rioxxterms.licenseref.uri | https://www.rioxx.net/licenses/under-embargo-all-rights-reserved | |
rioxxterms.licenseref.startdate | 2017-12 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | Biochimica et biophysica acta. Reviews on cancer | |
pubs.issue | 2 | |
pubs.notes | No embargo | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Biology of Childhood Leukaemia | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Biology of Childhood Leukaemia | |
pubs.publication-status | Published | |
pubs.volume | 1868 | |
pubs.embargo.terms | No embargo | |
icr.researchteam | Biology of Childhood Leukaemia | |
dc.contributor.icrauthor | Ford, Anthony | |