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CancerGD: A Resource for Identifying and Interpreting Genetic Dependencies in Cancer.

dc.contributor.authorBridgett, S
dc.contributor.authorCampbell, J
dc.contributor.authorLord, CJ
dc.contributor.authorRyan, CJ
dc.date.accessioned2017-12-06T12:24:16Z
dc.date.issued2017-07-26
dc.identifier.citationCell systems, 2017, 5 (1), pp. 82 - 86.e3
dc.identifier.issn2405-4712
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/963
dc.identifier.eissn2405-4720
dc.identifier.doi10.1016/j.cels.2017.06.002
dc.description.abstractGenes whose function is selectively essential in the presence of cancer-associated genetic aberrations represent promising targets for the development of precision therapeutics. Here, we present CancerGD, a resource that integrates genotypic profiling with large-scale loss-of-function genetic screens in tumor cell lines to identify such genetic dependencies. CancerGD provides tools for searching, visualizing, and interpreting these genetic dependencies through the integration of functional interaction networks. CancerGD includes different screen types (siRNA, shRNA, CRISPR), and we describe a simple format for submitting new datasets.
dc.formatPrint-Electronic
dc.format.extent82 - 86.e3
dc.languageeng
dc.language.isoeng
dc.publisherCELL PRESS
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subjectCell Line, Tumor
dc.subjectHumans
dc.subjectNeoplasms
dc.subjectGenetic Predisposition to Disease
dc.subjectRNA, Small Interfering
dc.subjectGene Expression Profiling
dc.subjectGenomics
dc.subjectGenotype
dc.subjectSystems Integration
dc.subjectSoftware
dc.subjectHealth Resources
dc.subjectGenetic Testing
dc.subjectClustered Regularly Interspaced Short Palindromic Repeats
dc.subjectDatasets as Topic
dc.subjectPrecision Medicine
dc.titleCancerGD: A Resource for Identifying and Interpreting Genetic Dependencies in Cancer.
dc.typeJournal Article
dcterms.dateAccepted2017-06-08
rioxxterms.versionofrecord10.1016/j.cels.2017.06.002
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2017-07-12
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfCell systems
pubs.issue1
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Gene Function
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Gene Function
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Gene Function
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Gene Function
pubs.publication-statusPublished
pubs.volume5
pubs.embargo.termsNot known
icr.researchteamGene Function
dc.contributor.icrauthorCampbell, James
dc.contributor.icrauthorLord, Christopher


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