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dc.contributor.authorAnnibaldi, Aen_US
dc.contributor.authorMeier, Pen_US
dc.date.accessioned2017-12-22T10:09:58Z
dc.date.issued2018-01en_US
dc.identifier.citationTrends in molecular medicine, 2018, 24 (1), pp. 49 - 65en_US
dc.identifier.issn1471-4914en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/986
dc.identifier.eissn1471-499Xen_US
dc.identifier.doi10.1016/j.molmed.2017.11.002en_US
dc.description.abstractTumor necrosis factor (TNF) is a proinflammatory cytokine that coordinates tissue homeostasis by regulating cytokine production, cell survival, and cell death. However, how life and death decisions are made in response to TNF is poorly understood. Many inflammatory pathologies are now recognized to be driven by aberrant TNF-induced cell death, which, in most circumstances, depends on the kinase Receptor-interacting serine/threonine-protein kinase 1 (RIPK1). Recent advances have identified ubiquitin (Ub)-mediated phosphorylation of RIPK1 as belonging to crucial checkpoints for cell fate in inflammation and infection. A better understanding of these checkpoints might lead to new approaches for the treatment of chronic inflammatory diseases fueled by aberrant RIPK1-induced cell death, and/or reveal novel strategies for anticancer immunotherapies, harnessing the ability of RIPK1 to trigger immunogenic cell death.en_US
dc.formatPrint-Electronicen_US
dc.format.extent49 - 65en_US
dc.languageengen_US
dc.language.isoengen_US
dc.rights.urihttp://www.rioxx.net/licenses/under-embargo-all-rights-reserveden_US
dc.subjectAnimalsen_US
dc.subjectHumansen_US
dc.subjectNeoplasmsen_US
dc.subjectInflammationen_US
dc.subjectTumor Necrosis Factor-alphaen_US
dc.subjectNF-kappa Ben_US
dc.subjectUbiquitinen_US
dc.subjectCell Deathen_US
dc.subjectReceptor-Interacting Protein Serine-Threonine Kinasesen_US
dc.titleCheckpoints in TNF-Induced Cell Death: Implications in Inflammation and Cancer.en_US
dc.typeJournal Article
dcterms.dateAccepted2017-11-13en_US
rioxxterms.versionofrecord10.1016/j.molmed.2017.11.002en_US
rioxxterms.licenseref.startdate2018-01en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfTrends in molecular medicineen_US
pubs.issue1en_US
pubs.notesNo embargoen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Cell Death and Immunity
pubs.publication-statusPublisheden_US
pubs.volume24en_US
pubs.embargo.termsNo embargoen_US
icr.researchteamCell Death and Immunityen_US
dc.contributor.icrauthorMeier, Pascalen_US


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