A comparison of the diagnostic value of MRI and 18 F-FDG-PET/CT in suspected spondylodiscitis.
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Authors
Smids, C
Kouijzer, IJE
Vos, FJ
Sprong, T
Hosman, AJF
de Rooy, JWJ
Aarntzen, EHJG
de Geus-Oei, L-F
Oyen, WJG
Bleeker-Rovers, CP
Kouijzer, IJE
Vos, FJ
Sprong, T
Hosman, AJF
de Rooy, JWJ
Aarntzen, EHJG
de Geus-Oei, L-F
Oyen, WJG
Bleeker-Rovers, CP
Document Type
Journal Article
Date
2017-02
Date Accepted
2016-06-03
Abstract
Purpose The purpose of this study was to evaluate the diagnostic value of 18 F-fluorodeoxyglucose (FDG) positron emission tomography and computed tomography (PET/CT scan) and magnetic resonance imaging (MRI) in diagnosing spondylodiscitis and its complications, such as epidural and paraspinal abscesses.Methods From January 2006 to August 2013 patients with a clinical suspicion of spondylodiscitis, with an infection, or with fever of unknown origin were retrospectively included if 18 F-FDG-PET/CT and MRI of the spine were performed within a 2-week time span. Imaging results were compared to the final clinical diagnosis and follow-up data were collected.Results Sixty-eight patients were included of whom 49 patients were diagnosed with spondylodiscitis. MRI showed an overall sensitivity of 67 % and specificity of 84 %. Diagnostic accuracy was 58 %, when MRI was performed within 2 weeks after the start of symptoms and improved to 82 %, when performed more than 2 weeks after onset of symptoms. 18 F-FDG-PET/CT showed a sensitivity of 96 % and a specificity of 95 %, with no relation to the interval between the scan and the start of symptoms.Conclusions As compared to MRI, 18 F-FDG-PET/CT has superior diagnostic value for detecting early spondylodiscitis. After 2 weeks both techniques perform similarly.
Citation
Infection, 2017, 45 (1), pp. 41 - 49
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Publisher
ISSN
0300-8126
eISSN
1439-0973
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Research Team
Translational Molecular Imaging