The Association of Intraoperative driving pressure with postoperative pulmonary complications in open versus closed abdominal surgery patients - a posthoc propensity score-weighted cohort analysis of the LAS VEGAS study.
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Embargo End Date
ICR Authors
Authors
Mazzinari, G
Serpa Neto, A
Hemmes, SNT
Hedenstierna, G
Jaber, S
Hiesmayr, M
Hollmann, MW
Mills, GH
Vidal Melo, MF
Pearse, RM
Putensen, C
Schmid, W
Severgnini, P
Wrigge, H
Cambronero, OD
Ball, L
de Abreu, MG
Pelosi, P
Schultz, MJ
LAS VEGAS study–investigators,
PROtective VEntilation NETwork,
Clinical Trial Network of the European Society of Anaesthesiology,
Serpa Neto, A
Hemmes, SNT
Hedenstierna, G
Jaber, S
Hiesmayr, M
Hollmann, MW
Mills, GH
Vidal Melo, MF
Pearse, RM
Putensen, C
Schmid, W
Severgnini, P
Wrigge, H
Cambronero, OD
Ball, L
de Abreu, MG
Pelosi, P
Schultz, MJ
LAS VEGAS study–investigators,
PROtective VEntilation NETwork,
Clinical Trial Network of the European Society of Anaesthesiology,
Document Type
Journal Article
Date
2021-03-19
Date Accepted
2021-01-25
Abstract
BACKGROUND: It is uncertain whether the association of the intraoperative driving pressure (ΔP) with postoperative pulmonary complications (PPCs) depends on the surgical approach during abdominal surgery. Our primary objective was to determine and compare the association of time-weighted average ΔP (ΔPTW) with PPCs. We also tested the association of ΔPTW with intraoperative adverse events. METHODS: Posthoc retrospective propensity score-weighted cohort analysis of patients undergoing open or closed abdominal surgery in the 'Local ASsessment of Ventilatory management during General Anaesthesia for Surgery' (LAS VEGAS) study, that included patients in 146 hospitals across 29 countries. The primary endpoint was a composite of PPCs. The secondary endpoint was a composite of intraoperative adverse events. RESULTS: The analysis included 1128 and 906 patients undergoing open or closed abdominal surgery, respectively. The PPC rate was 5%. ΔP was lower in open abdominal surgery patients, but ΔPTW was not different between groups. The association of ΔPTW with PPCs was significant in both groups and had a higher risk ratio in closed compared to open abdominal surgery patients (1.11 [95%CI 1.10 to 1.20], P < 0.001 versus 1.05 [95%CI 1.05 to 1.05], P < 0.001; risk difference 0.05 [95%CI 0.04 to 0.06], P < 0.001). The association of ΔPTW with intraoperative adverse events was also significant in both groups but had higher odds ratio in closed compared to open abdominal surgery patients (1.13 [95%CI 1.12- to 1.14], P < 0.001 versus 1.07 [95%CI 1.05 to 1.10], P < 0.001; risk difference 0.05 [95%CI 0.030.07], P < 0.001). CONCLUSIONS: ΔP is associated with PPC and intraoperative adverse events in abdominal surgery, both in open and closed abdominal surgery. TRIAL REGISTRATION: LAS VEGAS was registered at clinicaltrials.gov (trial identifier NCT01601223 ).
Citation
BMC anesthesiology, 2021, 21 (1), pp. 84 - ?
Source Title
Publisher
BMC
ISSN
1471-2253
eISSN
1471-2253
1471-2253
1471-2253