Defining aggressive or early progressing nononcogene-addicted non-small-cell lung cancer: a separate disease entity?
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Embargo End Date
ICR Authors
Authors
Reck, M
Kerr, KM
Grohé, C
Manegold, C
Pavlakis, N
Paz-Ares, L
Huber, RM
Popat, S
Thatcher, N
Park, K
Hilberg, F
Barrueco, J
Kaiser, R
Kerr, KM
Grohé, C
Manegold, C
Pavlakis, N
Paz-Ares, L
Huber, RM
Popat, S
Thatcher, N
Park, K
Hilberg, F
Barrueco, J
Kaiser, R
Document Type
Journal Article
Date
2019-04
Date Accepted
Abstract
A substantial proportion of patients with nononcogene-addicted non-small-cell lung cancer (NSCLC) has 'aggressive disease', as reflected in short time to progression or lack of disease control with initial platinum-based chemotherapy. Recently, clinical correlates of aggressive disease behavior during first-line therapy have been shown to predict greater benefit from addition of nintedanib to second-line docetaxel in adenocarcinoma NSCLC. Positive predictive effects of aggressive disease have since been reported with other anti-angiogenic agents (ramucirumab and bevacizumab), while such features may negatively impact on outcomes with nivolumab in nonsquamous NSCLC with low PD-L1 expression. Based on a review of the clinical data, we recommend aggressive nonsquamous NSCLC should be defined by progression within <6-9 months of first-line treatment initiation.
Citation
Future oncology (London, England), 2019, 15 (12), pp. 1363 - 1383
Source Title
Publisher
ISSN
1479-6694
eISSN
1744-8301
Collections
Research Team
Thoracic Oncology