MicroRNAs as mediators of drug resistance mechanisms.
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Authors
Lampis, A
Hahne, JC
Hedayat, S
Valeri, N
Hahne, JC
Hedayat, S
Valeri, N
Document Type
Journal Article
Date
2020-10-01
Date Accepted
2020-08-05
Abstract
MicroRNAs are small RNA transcripts involved in fine-tuning of several cellular mechanisms and pathways crucial for maintaining cells' homeostasis like apoptosis, differentiation, inflammation and cell-cycle regulation. They act by regulation of gene expression at post-transcriptional level through fine-tuning of target proteins expression. Expression of microRNAs is cell-type specific and since their discovery they have been proven to be deregulated in various disorders including cancer. Several lines of evidence are emerging that link microRNAs to drug resistance mechanisms in tumours given their important role in modulating oncogenic and tumour suppressive mechanisms. This review will focus on latest knowledge of the roles and mechanisms of microRNAs as mediators to drug resistance and the implications for future therapies.
Citation
Current opinion in pharmacology, 2020, 54 pp. 44 - 50
Rights
Source Title
Publisher
ELSEVIER SCI LTD
ISSN
1471-4892
eISSN
1471-4973
Collections
Research Team
Evolutionary Genomics & Modelling
Functional Genomics
Gastrointestinal Cancer Biology and Genomics
Functional Genomics
Gastrointestinal Cancer Biology and Genomics