Beam selection for stereotactic ablative radiotherapy using Cyberknife with multileaf collimation.
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Embargo End Date
ICR Authors
Authors
Bedford, JL
Ziegenhein, P
Nill, S
Oelfke, U
Ziegenhein, P
Nill, S
Oelfke, U
Document Type
Journal Article
Date
2018-12-20
Date Accepted
2018-12-12
Abstract
The Cyberknife system (Accuray Inc., Sunnyvale, CA) enables radiotherapy using stereotactic ablative body radiotherapy (SABR) with a large number of non-coplanar beam orientations. Recently, a multileaf collimator has also been available to allow flexibility in field shaping. This work aims to evaluate the quality of treatment plans obtainable with the multileaf collimator. Specifically, the aim is to find a subset of beam orientations from a predetermined set of candidate directions, such that the treatment quality is maintained but the treatment time is reduced. An evolutionary algorithm is used to successively refine a randomly selected starting set of beam orientations. By using an efficient computational framework, clinically useful solutions can be found in several hours. It is found that 15 beam orientations are able to provide treatment quality which approaches that of the candidate beam set of 110 beam orientations, but with approximately half of the estimated treatment time. Choice of an efficient subset of beam orientations offers the possibility to improve the patient experience and maximise the number of patients treated.
Citation
Medical engineering & physics, 2019, 64 pp. 28 - 36
Source Title
Publisher
ELSEVIER SCI LTD
ISSN
1350-4533
eISSN
1873-4030
Collections
Research Team
Radiotherapy Physics Modelling
Radiotherapy treatment planning
Radiotherapy treatment planning