Vault RNAs: hidden gems in RNA and protein regulation.
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Embargo End Date
ICR Authors
Authors
Hahne, JC
Lampis, A
Valeri, N
Lampis, A
Valeri, N
Document Type
Journal Article
Date
2020-10-15
Date Accepted
2020-10-05
Abstract
Non-coding RNAs are important regulators of differentiation during embryogenesis as well as key players in the fine-tuning of transcription and furthermore, they control the post-transcriptional regulation of mRNAs under physiological conditions. Deregulated expression of non-coding RNAs is often identified as one major contribution in a number of pathological conditions. Non-coding RNAs are a heterogenous group of RNAs and they represent the majority of nuclear transcripts in eukaryotes. An evolutionary highly conserved sub-group of non-coding RNAs is represented by vault RNAs, named since firstly discovered as component of the largest known ribonucleoprotein complexes called "vault". Although they have been initially described 30 years ago, vault RNAs are largely unknown and their molecular role is still under investigation. In this review we will summarize the known functions of vault RNAs and their involvement in cellular mechanisms.
Citation
Cellular and molecular life sciences : CMLS, 2020
Source Title
Publisher
SPRINGER BASEL AG
ISSN
1420-682X
eISSN
1420-9071
Collections
Research Team
Evolutionary Genomics & Modelling
Gastrointestinal Cancer Biology and Genomics
Evolutionary Genomics & Modelling
Gastrointestinal Cancer Biology and Genomics
Gastrointestinal Cancer Biology and Genomics
Evolutionary Genomics & Modelling
Gastrointestinal Cancer Biology and Genomics