Understanding and overcoming tumor heterogeneity in metastatic breast cancer treatment.
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Embargo End Date
ICR Authors
Authors
Pasha, N
Turner, NC
Turner, NC
Document Type
Journal Article
Date
2021-07-19
Date Accepted
2021-06-02
Abstract
Rational development of targeted therapies has revolutionized metastatic breast cancer outcomes, although resistance to treatment remains a major challenge. Advances in molecular profiling and imaging technologies have provided evidence for the impact of clonal diversity in cancer treatment resistance, through the outgrowth of resistant clones. In this Review, we focus on the genomic processes that drive tumoral heterogeneity and the mechanisms of resistance underlying metastatic breast cancer treatment and discuss implications for future treatment strategies.
Citation
NATURE CANCER, 2021, 2 (7), pp. 680 - 692 (13)
Source Title
Publisher
NATURE PORTFOLIO
ISSN
eISSN
2662-1347
2662-1347
2662-1347
Collections
Research Team
Molecular Oncology