Spatial analyses of immune cell infiltration in cancer: current methods and future directions: A report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer.
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ICR Authors
Authors
Page, DB
Broeckx, G
Jahangir, CA
Verbandt, S
Gupta, RR
Thagaard, J
Khiroya, R
Kos, Z
Abduljabbar, K
Acosta Haab, G
Acs, B
Akturk, G
Almeida, JS
Alvarado-Cabrero, I
Azmoudeh-Ardalan, F
Badve, S
Baharun, NB
Bellolio, ER
Bheemaraju, V
Blenman, KR
Botinelly Mendonça Fujimoto, L
Bouchmaa, N
Burgues, O
Cheang, MCU
Ciompi, F
Cooper, LA
Coosemans, A
Corredor, G
Dantas Portela, FL
Deman, F
Demaria, S
Dudgeon, SN
Elghazawy, M
Ely, S
Fernandez-Martín, C
Fineberg, S
Fox, SB
Gallagher, WM
Giltnane, JM
Gnjatic, S
Gonzalez-Ericsson, PI
Grigoriadis, A
Halama, N
Hanna, MG
Harbhajanka, A
Hardas, A
Hart, SN
Hartman, J
Hewitt, S
Hida, AI
Horlings, HM
Husain, Z
Hytopoulos, E
Irshad, S
Janssen, EA
Kahila, M
Kataoka, TR
Kawaguchi, K
Kharidehal, D
Khramtsov, AI
Kiraz, U
Kirtani, P
Kodach, LL
Korski, K
Kovács, A
Laenkholm, A-V
Lang-Schwarz, C
Larsimont, D
Lennerz, JK
Lerousseau, M
Li, X
Ly, A
Madabhushi, A
Maley, SK
Manur Narasimhamurthy, V
Marks, DK
McDonald, ES
Mehrotra, R
Michiels, S
Minhas, FUAA
Mittal, S
Moore, DA
Mushtaq, S
Nighat, H
Papathomas, T
Penault-Llorca, F
Perera, RD
Pinard, CJ
Pinto-Cardenas, JC
Pruneri, G
Pusztai, L
Rahman, A
Rajpoot, NM
Rapoport, BL
Rau, TT
Reis-Filho, JS
Ribeiro, JM
Rimm, D
Vincent-Salomon, A
Salto-Tellez, M
Saltz, J
Sayed, S
Siziopikou, KP
Sotiriou, C
Stenzinger, A
Sughayer, MA
Sur, D
Symmans, F
Tanaka, S
Taxter, T
Tejpar, S
Teuwen, J
Thompson, EA
Tramm, T
Tran, WT
van der Laak, J
van Diest, PJ
Verghese, GE
Viale, G
Vieth, M
Wahab, N
Walter, T
Waumans, Y
Wen, HY
Yang, W
Yuan, Y
Adams, S
Bartlett, JMS
Loibl, S
Denkert, C
Savas, P
Loi, S
Salgado, R
Specht Stovgaard, E
Broeckx, G
Jahangir, CA
Verbandt, S
Gupta, RR
Thagaard, J
Khiroya, R
Kos, Z
Abduljabbar, K
Acosta Haab, G
Acs, B
Akturk, G
Almeida, JS
Alvarado-Cabrero, I
Azmoudeh-Ardalan, F
Badve, S
Baharun, NB
Bellolio, ER
Bheemaraju, V
Blenman, KR
Botinelly Mendonça Fujimoto, L
Bouchmaa, N
Burgues, O
Cheang, MCU
Ciompi, F
Cooper, LA
Coosemans, A
Corredor, G
Dantas Portela, FL
Deman, F
Demaria, S
Dudgeon, SN
Elghazawy, M
Ely, S
Fernandez-Martín, C
Fineberg, S
Fox, SB
Gallagher, WM
Giltnane, JM
Gnjatic, S
Gonzalez-Ericsson, PI
Grigoriadis, A
Halama, N
Hanna, MG
Harbhajanka, A
Hardas, A
Hart, SN
Hartman, J
Hewitt, S
Hida, AI
Horlings, HM
Husain, Z
Hytopoulos, E
Irshad, S
Janssen, EA
Kahila, M
Kataoka, TR
Kawaguchi, K
Kharidehal, D
Khramtsov, AI
Kiraz, U
Kirtani, P
Kodach, LL
Korski, K
Kovács, A
Laenkholm, A-V
Lang-Schwarz, C
Larsimont, D
Lennerz, JK
Lerousseau, M
Li, X
Ly, A
Madabhushi, A
Maley, SK
Manur Narasimhamurthy, V
Marks, DK
McDonald, ES
Mehrotra, R
Michiels, S
Minhas, FUAA
Mittal, S
Moore, DA
Mushtaq, S
Nighat, H
Papathomas, T
Penault-Llorca, F
Perera, RD
Pinard, CJ
Pinto-Cardenas, JC
Pruneri, G
Pusztai, L
Rahman, A
Rajpoot, NM
Rapoport, BL
Rau, TT
Reis-Filho, JS
Ribeiro, JM
Rimm, D
Vincent-Salomon, A
Salto-Tellez, M
Saltz, J
Sayed, S
Siziopikou, KP
Sotiriou, C
Stenzinger, A
Sughayer, MA
Sur, D
Symmans, F
Tanaka, S
Taxter, T
Tejpar, S
Teuwen, J
Thompson, EA
Tramm, T
Tran, WT
van der Laak, J
van Diest, PJ
Verghese, GE
Viale, G
Vieth, M
Wahab, N
Walter, T
Waumans, Y
Wen, HY
Yang, W
Yuan, Y
Adams, S
Bartlett, JMS
Loibl, S
Denkert, C
Savas, P
Loi, S
Salgado, R
Specht Stovgaard, E
Document Type
Journal Article
Date
2023-08-01
Date Accepted
2023-06-19
Abstract
Modern histologic imaging platforms coupled with machine learning methods have provided new opportunities to map the spatial distribution of immune cells in the tumor microenvironment. However, there exists no standardized method for describing or analyzing spatial immune cell data, and most reported spatial analyses are rudimentary. In this review, we provide an overview of two approaches for reporting and analyzing spatial data (raster versus vector-based). We then provide a compendium of spatial immune cell metrics that have been reported in the literature, summarizing prognostic associations in the context of a variety of cancers. We conclude by discussing two well-described clinical biomarkers, the breast cancer stromal tumor infiltrating lymphocytes score and the colon cancer Immunoscore, and describe investigative opportunities to improve clinical utility of these spatial biomarkers. © 2023 The Pathological Society of Great Britain and Ireland.
Citation
Journal of Pathology, 2023, 260 (5), pp. 514 - 532
Rights
Source Title
Journal of Pathology
Publisher
WILEY
ISSN
0022-3417
eISSN
1096-9896
1096-9896
1096-9896
Collections
Research Team
Clin Trials & Stats Unit