Kaposi's sarcoma-associated herpesvirus-infected primary effusion lymphoma has a plasma cell gene expression profile
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ICR Authors
Authors
Jenner, RG
Maillard, K
Cattini, N
Weiss, RA
Boshoff, C
Wooster, R
Kellam, P
Maillard, K
Cattini, N
Weiss, RA
Boshoff, C
Wooster, R
Kellam, P
Document Type
Journal Article
Date
2003-09-02
Date Accepted
Abstract
<jats:p>Kaposi's sarcoma-associated herpesvirus is associated with three human
tumors: Kaposi's sarcoma, and the B cell lymphomas, plasmablastic lymphoma
associated with multicentric Castleman's disease, and primary effusion
lymphoma (PEL). Epstein-Barr virus, the closest human relative of Kaposi's
sarcoma-associated herpesvirus, mimics host B cell signaling pathways to
direct B cell development toward a memory B cell phenotype. Epstein-Barr
virus-associated B cell tumors are presumed to arise as a consequence of this
virus-mediated B cell activation. The stage of B cell development represented
by PEL, how this stage relates to tumor pathology, and how this information
may be used to treat the disease are largely unknown. In this study we used
gene expression profiling to order a range of B cell tumors by stage of
development. PEL gene expression closely resembles that of malignant plasma
cells, including the low expression of mature B cell genes. The unfolded
protein response is partially activated in PEL, but is fully activated in
plasma cell tumors, linking endoplasmic reticulum stress to plasma cell
development through XBP-1. PEL cells can be defined by the overexpression of
genes involved in inflammation, cell adhesion, and invasion, which may be
responsible for their presentation in body cavities. Similar to malignant
plasma cells, all PEL samples tested express the vitamin D receptor and are
sensitive to the vitamin D analogue drug EB 1089 (Seocalcitol).</jats:p>
Citation
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 pp. 10399 - 10404
Source Title
Publisher
Proceedings of the National Academy of Sciences
ISSN
0027-8424