Androgen deprivation therapy for androgen receptor-positive advanced salivary duct carcinoma: A nationwide case series of 35 patients in The Netherlands.
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Authors
Boon, E
van Boxtel, W
Buter, J
Baatenburg de Jong, RJ
van Es, RJJ
Bel, M
Fiets, E
Oosting, SF
Slingerland, M
Hoeben, A
Tesselaar, MET
Jonker, MA
Flucke, UE
Nationwide Network and Registry of Histopathology and Cytopathology (PALGA) Group
van der Graaf, WTA
van Herpen, CML
van Boxtel, W
Buter, J
Baatenburg de Jong, RJ
van Es, RJJ
Bel, M
Fiets, E
Oosting, SF
Slingerland, M
Hoeben, A
Tesselaar, MET
Jonker, MA
Flucke, UE
Nationwide Network and Registry of Histopathology and Cytopathology (PALGA) Group
van der Graaf, WTA
van Herpen, CML
Document Type
Journal Article
Date
2018-03
Date Accepted
2017-10-25
Abstract
Background Salivary duct carcinoma, an aggressive subtype of salivary gland cancer, is mostly androgen receptor-positive. Only limited data are available on androgen deprivation therapy (ADT).Methods Patients with advanced androgen receptor-positive salivary duct carcinoma treated with first-line ADT were retrospectively evaluated for clinical benefit (ie, partial response [PR] and stable disease, progression-free survival [PFS] and overall survival [OS]). The OS was compared with patients with advanced salivary duct carcinoma who received best supportive care.Results Thirty-four of 35 patients who were ADT-treated were evaluable: 6 patients had a PR (18%) and 11 had stable disease (32%) leading to a clinical benefit ratio of 50%. The median PFS for the ADT-treated patients was 4 months and the median duration of clinical benefit was 11 months. The median OS was 17 months versus 5 months in 43 patients receiving best supportive care (P = .02).Conclusion We recommend ADT in advanced androgen receptor-positive salivary duct carcinoma given its response and clinical benefit. © 2017 Wiley Periodicals, Inc. Head Neck, 2017.
Citation
Head & neck, 2018, 40 (3), pp. 605 - 613
Source Title
Publisher
ISSN
1043-3074
eISSN
1097-0347
Collections
Research Team
Clinical and Translational Sarcoma