Validation of loci at 2q14.2 and 15q21.3 as risk factors for testicular cancer.
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Authors
Loveday, C
Litchfield, K
Levy, M
Holroyd, A
Broderick, P
Kote-Jarai, Z
Dunning, AM
Muir, K
Peto, J
Eeles, R
Easton, DF
Dudakia, D
Orr, N
Pashayan, N
Reid, A
Huddart, RA
Houlston, RS
Turnbull, C
Litchfield, K
Levy, M
Holroyd, A
Broderick, P
Kote-Jarai, Z
Dunning, AM
Muir, K
Peto, J
Eeles, R
Easton, DF
Dudakia, D
Orr, N
Pashayan, N
Reid, A
Huddart, RA
Houlston, RS
Turnbull, C
Document Type
Journal Article
Date
2018-02-27
Date Accepted
2017-11-15
Abstract
Testicular germ cell tumor (TGCT), the most common cancer in men aged 18 to 45 years, has a strong heritable basis. Genome-wide association studies (GWAS) have proposed single nucleotide polymorphisms (SNPs) at a number of loci influencing TGCT risk. To further evaluate the association of recently proposed risk SNPs with TGCT at 2q14.2, 3q26.2, 7q36.3, 10q26.13 and 15q21.3, we analyzed genotype data on 3,206 cases and 7,422 controls. Our analysis provides independent replication of the associations for risk SNPs at 2q14.2 (rs2713206 at P = 3.03 × 10-2; P-meta = 3.92 × 10-8; nearest gene, TFCP2L1) and rs12912292 at 15q21.3 (P = 7.96 × 10-11; P-meta = 1.55 × 10-19; nearest gene PRTG). Case-only analyses did not reveal specific associations with TGCT histology. TFCP2L1 joins the growing list of genes located within TGCT risk loci with biologically plausible roles in developmental transcriptional regulation, further highlighting the importance of this phenomenon in TGCT oncogenesis.
Citation
Oncotarget, 2018, 9 (16), pp. 12630 - 12638
Source Title
Publisher
Impact Journals, LLC
ISSN
1949-2553
eISSN
1949-2553
Research Team
Complex Trait Genetics
Cancer Genomics
Molecular & Population Genetics
Clinical Academic Radiotherapy (Huddart)
Oncogenetics
Cancer Genomics
Molecular & Population Genetics
Clinical Academic Radiotherapy (Huddart)
Oncogenetics