Evidence of Chemoresponsiveness in Unresectable Metastatic Angiomatoid Fibrous Histiocytoma.
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Embargo End Date
ICR Authors
Authors
Corley, EA
Pace, E
Barnacle, AM
Patel, PA
Thway, K
Chisholm, JC
Pace, E
Barnacle, AM
Patel, PA
Thway, K
Chisholm, JC
Document Type
Journal Article
Date
2023-01-16
Date Accepted
2022-11-13
Abstract
Angiomatoid fibrous histiocytoma (AFH) is a soft tissue neoplasm of intermediate biological potential. Typically a slow-growing tumor, it can recur locally. Rarely, it manifests as a soft tissue sarcoma capable of metastasis. When metastases are nonamenable to local therapy, it is believed uniformly fatal. We present 3 patients with metastatic AFH who demonstrated a sustained response to chemotherapy; including one who achieved complete remission with cryoablation. These cases reinforce the potential value of chemotherapy in some patients with unresectable metastatic AFH and provide the first case in the literature of cryoablation in AFH.
Citation
Journal of Pediatric Hematology/Oncology, 2023, Publish Ahead of Print
Source Title
Journal of Pediatric Hematology/Oncology
Publisher
Ovid Technologies (Wolters Kluwer Health)
ISSN
1077-4114
eISSN
1536-3678
1536-3678
1536-3678