Analysis of 153 115 patients with hematological malignancies refines the spectrum of familial risk.
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ICR Authors
Authors
Sud, A
Chattopadhyay, S
Thomsen, H
Sundquist, K
Sundquist, J
Houlston, RS
Hemminki, K
Chattopadhyay, S
Thomsen, H
Sundquist, K
Sundquist, J
Houlston, RS
Hemminki, K
Document Type
Journal Article
Date
2019-09
Date Accepted
2019-06-26
Abstract
Estimating familial cancer risks is clinically important in being able to discriminate between individuals in the population at differing risk for malignancy. To gain insight into the familial risk for the different hematological malignancies and their possible inter-relationship, we analyzed data on more than 16 million individuals from the Swedish Family-Cancer Database. After identifying 153 115 patients diagnosed with a primary hematological malignancy, we quantified familial relative risks (FRRs) by calculating standardized incident ratios (SIRs) in 391 131 of their first-degree relatives. The majority of hematological malignancies showed increased FRRs for the same tumor type, with the highest FRRs being observed for mixed cellularity Hodgkin lymphoma (SIR, 16.7), lymphoplasmacytic lymphoma (SIR, 15.8), and mantle cell lymphoma (SIR, 13.3). There was evidence for pleiotropic relationships; notably, chronic lymphocytic leukemia was associated with an elevated familial risk for other B-cell tumors and myeloproliferative neoplasms. Collectively, these data provide evidence for shared etiological factors for many hematological malignancies and provide information for identifying individuals at increased risk, as well as informing future gene discovery initiatives.
Citation
Blood, 2019, 134 (12), pp. 960 - 969
Source Title
Publisher
ELSEVIER
ISSN
0006-4971
eISSN
1528-0020
Collections
Research Team
Cancer Genomics