Detecting repeated cancer evolution from multi-region tumor sequencing data.
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Embargo End Date
ICR Authors
Authors
Caravagna, G
Giarratano, Y
Ramazzotti, D
Tomlinson, I
Graham, TA
Sanguinetti, G
Sottoriva, A
Giarratano, Y
Ramazzotti, D
Tomlinson, I
Graham, TA
Sanguinetti, G
Sottoriva, A
Document Type
Journal Article
Date
2018-08-31
Date Accepted
2018-07-23
Abstract
Recurrent successions of genomic changes, both within and between patients, reflect repeated evolutionary processes that are valuable for the anticipation of cancer progression. Multi-region sequencing allows the temporal order of some genomic changes in a tumor to be inferred, but the robust identification of repeated evolution across patients remains a challenge. We developed a machine-learning method based on transfer learning that allowed us to overcome the stochastic effects of cancer evolution and noise in data and identified hidden evolutionary patterns in cancer cohorts. When applied to multi-region sequencing datasets from lung, breast, renal, and colorectal cancer (768 samples from 178 patients), our method detected repeated evolutionary trajectories in subgroups of patients, which were reproduced in single-sample cohorts (n = 2,935). Our method provides a means of classifying patients on the basis of how their tumor evolved, with implications for the anticipation of disease progression.
Citation
2017
DOI
Source Title
Publisher
NATURE PUBLISHING GROUP
ISSN
eISSN
Research Team
Paediatric Solid Tumour Biology and Therapeutics