Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia.
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Authors
Vijayakrishnan, J
Studd, J
Broderick, P
Kinnersley, B
Holroyd, A
Law, PJ
Kumar, R
Allan, JM
Harrison, CJ
Moorman, AV
Vora, A
Roman, E
Rachakonda, S
Kinsey, SE
Sheridan, E
Thompson, PD
Irving, JA
Koehler, R
Hoffmann, P
Nöthen, MM
Heilmann-Heimbach, S
Jöckel, K-H
Easton, DF
Pharaoh, PDP
Dunning, AM
Peto, J
Canzian, F
Swerdlow, A
Eeles, RA
Kote-Jarai, Z
Muir, K
Pashayan, N
PRACTICAL Consortium,
Greaves, M
Zimmerman, M
Bartram, CR
Schrappe, M
Stanulla, M
Hemminki, K
Houlston, RS
Studd, J
Broderick, P
Kinnersley, B
Holroyd, A
Law, PJ
Kumar, R
Allan, JM
Harrison, CJ
Moorman, AV
Vora, A
Roman, E
Rachakonda, S
Kinsey, SE
Sheridan, E
Thompson, PD
Irving, JA
Koehler, R
Hoffmann, P
Nöthen, MM
Heilmann-Heimbach, S
Jöckel, K-H
Easton, DF
Pharaoh, PDP
Dunning, AM
Peto, J
Canzian, F
Swerdlow, A
Eeles, RA
Kote-Jarai, Z
Muir, K
Pashayan, N
PRACTICAL Consortium,
Greaves, M
Zimmerman, M
Bartram, CR
Schrappe, M
Stanulla, M
Hemminki, K
Houlston, RS
Document Type
Journal Article
Date
2018-04-09
Date Accepted
2018-01-25
Abstract
Genome-wide association studies (GWAS) have advanced our understanding of susceptibility to B-cell precursor acute lymphoblastic leukemia (BCP-ALL); however, much of the heritable risk remains unidentified. Here, we perform a GWAS and conduct a meta-analysis with two existing GWAS, totaling 2442 cases and 14,609 controls. We identify risk loci for BCP-ALL at 8q24.21 (rs28665337, P = 3.86 × 10-9, odds ratio (OR) = 1.34) and for ETV6-RUNX1 fusion-positive BCP-ALL at 2q22.3 (rs17481869, P = 3.20 × 10-8, OR = 2.14). Our findings provide further insights into genetic susceptibility to ALL and its biology.
Citation
Nature communications, 2018, 9 (1), pp. 1340 - ?
Source Title
Publisher
NATURE PORTFOLIO
ISSN
2041-1723
eISSN
2041-1723
Research Team
Aetiological Epidemiology
Cancer Genomics
Biology of Childhood Leukaemia
Myeloma Group
Oncogenetics
Cancer Genomics
Biology of Childhood Leukaemia
Myeloma Group
Oncogenetics