canSAR: an integrated cancer public translational research and drug discovery resource.

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Authors

Halling-Brown, MD
Bulusu, KC
Patel, M
Tym, JE
Al-Lazikani, B

Document Type

Journal Article

Date

2012-01-01

Date Accepted

Date Available

Abstract

canSAR is a fully integrated cancer research and drug discovery resource developed to utilize the growing publicly available biological annotation, chemical screening, RNA interference screening, expression, amplification and 3D structural data. Scientists can, in a single place, rapidly identify biological annotation of a target, its structural characterization, expression levels and protein interaction data, as well as suitable cell lines for experiments, potential tool compounds and similarity to known drug targets. canSAR has, from the outset, been completely use-case driven which has dramatically influenced the design of the back-end and the functionality provided through the interfaces. The Web interface at http://cansar.icr.ac.uk provides flexible, multipoint entry into canSAR. This allows easy access to the multidisciplinary data within, including target and compound synopses, bioactivity views and expert tools for chemogenomic, expression and protein interaction network data.

Citation

Nucleic acids research, 2012, 40 (Database issue), pp. D947 - D956

Source Title

Publisher

OXFORD UNIV PRESS

ISSN

0305-1048

eISSN

1362-4962

Research Team

Computational Biology and Chemogenomics

Notes