The transformation of radiation oncology using real-time magnetic resonance guidance: A review.
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Embargo End Date
ICR Authors
Authors
Hall, WA
Paulson, ES
van der Heide, UA
Fuller, CD
Raaymakers, BW
Lagendijk, JJW
Li, XA
Jaffray, DA
Dawson, LA
Erickson, B
Verheij, M
Harrington, KJ
Sahgal, A
Lee, P
Parikh, PJ
Bassetti, MF
Robinson, CG
Minsky, BD
Choudhury, A
Tersteeg, RJHA
Schultz, CJ
MR Linac Atlantic Consortium and the ViewRay C2T2 Research Consortium,
Paulson, ES
van der Heide, UA
Fuller, CD
Raaymakers, BW
Lagendijk, JJW
Li, XA
Jaffray, DA
Dawson, LA
Erickson, B
Verheij, M
Harrington, KJ
Sahgal, A
Lee, P
Parikh, PJ
Bassetti, MF
Robinson, CG
Minsky, BD
Choudhury, A
Tersteeg, RJHA
Schultz, CJ
MR Linac Atlantic Consortium and the ViewRay C2T2 Research Consortium,
Document Type
Journal Article
Date
2019-11-01
Date Accepted
2019-07-16
Abstract
Radiation therapy (RT) is an essential component of effective cancer care and is used across nearly all cancer types. The delivery of RT is becoming more precise through rapid advances in both computing and imaging. The direct integration of magnetic resonance imaging (MRI) with linear accelerators represents an exciting development with the potential to dramatically impact cancer research and treatment. These impacts extend beyond improved imaging and dose deposition. Real-time MRI-guided RT is actively transforming the work flows and capabilities of virtually every aspect of RT. It has the opportunity to change entirely the delivery methods and response assessments of numerous malignancies. This review intends to approach the topic of MRI-based RT guidance from a vendor neutral and international perspective. It also aims to provide an introduction to this topic targeted towards oncologists without a speciality focus in RT. Speciality implications, areas for physician education and research opportunities are identified as they are associated with MRI-guided RT. The uniquely disruptive implications of MRI-guided RT are discussed and placed in context. We further aim to describe and outline important future changes to the speciality of radiation oncology that will occur with MRI-guided RT. The impacts on RT caused by MRI guidance include target identification, RT planning, quality assurance, treatment delivery, training, clinical workflow, tumour response assessment and treatment scheduling. In addition, entirely novel research areas that may be enabled by MRI guidance are identified for future investigation.
Citation
European journal of cancer (Oxford, England : 1990), 2019, 122 pp. 42 - 52
Source Title
Publisher
ELSEVIER SCI LTD
ISSN
0959-8049
eISSN
1879-0852
Research Team
Targeted Therapy
Targeted Therapy
Targeted Therapy