A Mitsunobu reaction to functionalized cyclic and bicyclic <i>N</i>-arylamines
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Embargo End Date
ICR Authors
Authors
Gill, DM
Iveson, M
Collins, I
Jones, AM
Iveson, M
Collins, I
Jones, AM
Document Type
Journal Article
Date
2018-01-17
Date Accepted
2017-12-04
Abstract
The scope of an unexpected Mitsunobu cyclisation to prepare N-arylated Fsp3-enriched azacycles was investigated. In the current study, we have identified whether a pKa-dependent Mitsunobu cyclodehydration or a pKa-independent Mitsunobu intramolecular reaction was in operation. A Mitsunobu reaction, creating a leaving group, followed by intramolecular nucleophilic displacement was determined to be the dominant pathway.
Citation
TETRAHEDRON LETTERS, 2018, 59 (3), pp. 238 - 242 (5)
Source Title
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
ISSN
0040-4039
eISSN
Collections
Research Team
Medicinal Chemistry 2