Contributions to drug resistance in glioblastoma derived from malignant cells in the sub-ependymal zone.

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Authors

Piccirillo, SG
Spiteri, I
Sottoriva, A
Touloumis, A
Ber, S
Price, SJ
Heywood, R
Francis, N-J
Howarth, KD
Collins, VP
Venkitaraman, AR
Curtis, C
Marioni, JC
Tavaré, S
Watts, C

Document Type

Journal Article

Date

2015-01-01

Date Accepted

Abstract

Glioblastoma, the most common and aggressive adult brain tumor, is characterized by extreme phenotypic diversity and treatment failure. Through fluorescence-guided resection, we identified fluorescent tissue in the sub-ependymal zone (SEZ) of patients with glioblastoma. Histologic analysis and genomic characterization revealed that the SEZ harbors malignant cells with tumor-initiating capacity, analogous to cells isolated from the fluorescent tumor mass (T). We observed resistance to supramaximal chemotherapy doses along with differential patterns of drug response between T and SEZ in the same tumor. Our results reveal novel insights into glioblastoma growth dynamics, with implications for understanding and limiting treatment resistance.

Citation

Cancer research, 2015, 75 (1), pp. 194 - 202

Source Title

Publisher

AMER ASSOC CANCER RESEARCH

ISSN

0008-5472

eISSN

1538-7445

Research Team

Evolutionary Genomics & Modelling

Notes